The document discusses male and female hormones and their roles in reproduction. It describes the hypothalamic-pituitary-gonadal axis and how it regulates the release of hormones like estrogen, progesterone, testosterone and FSH/LH to control the menstrual cycle and spermatogenesis. It also summarizes various drugs that act on these hormones to treat infertility, contraception and other conditions.
This interesting ppt deals with pharmacological aspects of Gynecology highlighting various aspects of it...it'll be very useful for the beginners in Gynecology...
This interesting ppt deals with pharmacological aspects of Gynecology highlighting various aspects of it...it'll be very useful for the beginners in Gynecology...
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
3. FEMALE REPRODUCTIVE SYSTEM
HORMONAL REGULATION OF OOGENSIS AND OVULATION
OVULATION:
sharp surge in LH
with simulataneous
increase in FSH
Meiosis I resumes;
oocyte and surrounding
cumulus break away
and are extruded
oocyte passes into
oviduct
ECTOPIC
IMPLANTATIONS
6. Aromatase Inhibitors
• Used to inhibit estrogen-dependent tumors,
metastatic breast cancer.
• But, serious estrogen-lacking side-effects:
increased risk of osteoporosis.
• Anastrozole, letrozole, exemestane,
formestane.
7. Receptor Antagonists
• Selective Estrogen Receptor Modulators
(SERMs).
• Are mixed agonists/antagonists.
• ERα and ERβ types are tissue-specific.
• See next slide for how SERMs are tissue-
specific.
8.
9. SERMs
• Tamoxifen – an ER antagonist in breast, but a
partial agonist in endometrium and bone.
• Raloxifene – ER agonist in bone, but an
antagonist in both breast and endometrium.
• Clomifene – used to induce ovulation. Is an ER
antagonist in hypothalamus and ant pit, but a
partial agonist in ovaries.
10. Androgen Receptor Antagonists
Flutamide and spironolactone – used to treat
metastatic prostate cancer and BPH.
Progesterone Receptor Antagonists
Mifepristone (aka RU-486) – used to induce 1st-
trimester abortion.
Often admin with misoprostol (PG analogue) –
stimulates uterine contractions.
Asoprisnil – does not cause abortion, but inhibits
the growth of tissue derived from the
endometrium and myometrium.
May be used to treat endometriosis and uterine
fibroids.
11. Adrenal Sex Hormones
• Androgens – male hormones secreted by the adrenal
cortex in both sexes and are responsible for the
physiological effects exerted by adrenal sex hormones.
• The incr protein synthesis (anabolism), which incr
muscle and bone mass and strength, affect
development of male 2° characteristics. They incr hair
growth and libido in women. Excessive secretion:
masculine effects in women.
• Female sex hormones exert few effects. Excessive
secretion: feminine characteristics in men.
12. Drugs Affecting the Reproductive
System
Female hormones:
Estrogen and Progesterone
Example: Oral contraceptives (OCPs)
Estrogen prevents ovulation.
Progesterone prevents implantation of ovum,
decreases amount and increases viscosity of
cervical mucous to impair sperm motility, and
impedes motility of the ova by affecting
peristalsis of the ovaduct.
13. Infertility
Clomifene and Tamoxifen – anti-estrogens – work by
inhibiting the negative feedback of estrogens in the
hypothalamus Incr release of LH and FSH.
Gonadotropins – used in women who lack approp pit
function or do not respond to clomifene therapy.
Treatment starts with daily inj of menotrophin (LH =
FSH amts) or urofollitropin (FSH), followed by 1-2 large
doses of chorionic gonadotropin (mostly LH) to induce
ovulation.
Adverse Effects…? Multiple births…
In men with hypogonadotrophic hypogonadism, both LH
and FSH are given to stim spermatogenesis and
androgen release.
14. Testosterone
• ~ 2% of test in plasma is free.
• Converted to dihydrotestosterone (DHT) in skin,
prostate, seminal vesicles, and epididymus.
• Androgen deficiency – treated with i.m. injections
of testosterone propionate.
• Effects: At puberty 2° sexual characteristics in
male.
– In adult male, large doses gonadotrophin release
and atrophy of interstitial tissue and tubules (testes).
– In women, androgens changes seen in prepubertal
males.
15. Estrogens
• The main estrogen released by the ovary.
• Synthetic estrogens may be more effective following
oral administration.
• Adverse Effects (see below, oral contracep):
- prolonged administrations abnormal endometrial
hyperplasia, abnormal bleeding patterns, assoc with
incr incidence of endometrial cancer.
- But this cancer can be prevented it progestogen
accompanies the estrogen.
- Thus, women taking HRT must also take a
progestogen unless they have had a hysterectomy.
16. Progestogens
• Used for hormonal contraception and for
producing long-term ovarian suppression for
other purposes (e.g., dysmenorrhea,
endometriosis, hirsutism and bleeding
disorders) when estrogens are contra-
indicated
17. Oral Contraceptives
• Uses: Contraception, menstrual irregularities.
• Adverse Effects: hypertension, diabetes, high
LDL, dizziness, numbness, weight gain, fluid
retention, breast tenderness, breakthrough
bleeding.
• Contraindications: ABSOLUTE:
Thromboplebitis, CVA, breast cancer,
pregnancy, liver disease or impairment, CAD, >
35, smoker.
18. Oral Contraceptives
• Combination Pills – contain estrogen:
ethinylestradiol and progestogen, taken for ~
21 days and discontinued for the following 6-7
days to allow menstruation to occur.
• Progestogen-only Pills – contain low dose of
progestogen, taken continuously.
20. Oral Contraceptives - Mechanism
• Combination pills act by feedback inhibition on the
hypothal to supress GnRH and hence plasma
gonadotropin secretion.
• Produce an endometrium that is unreceptive to
implantation.
• Alter ovaduct motility.
• Change the composition of cervical mucous.
• These latter effects also caused by progestogen-only
pills and appear to be the basis of their contraceptive
actions.
• Block ovulation in only ~ 25% of women.
• Menstruation often stops initially with progestogens,
but usually returns with prolonged use.
• But the length and duration of bleeding – highly
variable.
21. Oral Contraceptives
• Combination of both E and P – most potent and
effective way to suppress GnRH, LH, and FSH
secretion.
• The combined effects on previous slide >99%
efficacy.
• Ethinyl estradiol or mestranol – the E in the
combination contraceptives.
• The progestins – all are potent PR agonists, but
also have some androgenic cross-reactivity.
Norgestrel and levonorgestrel > norethindrone
and norethindrone acetate > ethynodiol,
norgestimate, gestodene, and degestrel in
androgenic activity.
22. Oral Contraceptives
3 Delivery systems are available: vaginal ring,
transdermal patches, oral tablets.
Ring contains ethinyl estradiol and a progestin,
etonogestrel.
Has zero-order p’kinetics over 21 days.
Dermal patch has ethinyl estradiol and a
progestin, norelgestromin. – Changed weekly
for 3 weeks.
23. Oral Contraceptives – Adverse Effects
Non-life Threatening
• Breakthrough bleeding and irregular menses (most
women who take combo pills).
• Abdominal pain
• Chest pain, cough, dyspnea, dizziness, numbness,
headache, nausea, changes in libido, breast soreness.
• Eye problems: vision loss or blurred.
• Severe leg pain (calves, thighs).
• Hirsutism, vaginal yeast infections and depression.
• ~ 20-30 % women experience some of these effects.
24. Oral Contraceptives – Adverse Effects Serious
• Rare.
• Cholestatic jaundice and thromboembolic disease.
• Thromboembolism (~ 25/10,000 women).
Emergency (morning-after) Contraception –
levenorgestrel – a single high dose can be taken up to 3
days after unprotected intercourse. Blocks the LH
surge.
Therapeutic Termination of Pregnancy – mifepristone – a
progesterone ant – highly effective in terminating early
pregnancy (up to 63 days’ gestation) when used with a
PG-cervical ripening agent (e.g., gemeprost pessaries).
[Recall – Progesterone supports endometrial
implantation of fertilized ovum].
-Main adverse effect: pain and bleeding.
25. Male Contraception
• Tried suppressing sperm production.
- Very unsuccessful.
- Most promising to date: testosterone enanthate
+ daily oral levonorgestrel; and parenternal
ptestosterone undecanoate + injectable
medroxyprogesterone ascetate. But,…
- Highly variable results from clinical trials only
~ 60% of men became azoospermic.
Significant adverse effects: acne, weight gain,
polycythemia, potential increase in prostate size.
• “back to the drawing board…”
26. Infertility Drugs
• Example: Clomid
• Stimulates secretion of FSH and LH, which
stimulates maturation of follicles, ovulation
and development of the corpus luteum.
• Uses: Inadequate ovulation, low sperm count
in males.
• Adverse Effects: Similar to those of OCPs.
Increased incidence of early abortion and
multiple births, pelvic pain.
29. Male Hormones
• Example: Testosterone
• Secreted by the testes.
• Uses: Treatment of low sperm count and impotence caused
by any kind of deficiency.
Undescended testicles.
Anabolic action in conditions such as osteoporosis, anemia,
and debilitated states. Inoperable breast cancer in
postmenopausal women.
Adverse Effects: Edema, acne, hirsutism, voice deepening,
polycythemia, increased LDL, depression.
Contraindications: Pregnancy, prostate cancer, breast cancer
in males.