Chronic hepatitis C viral infection can cause thrombocytopenia through bone marrow hypoplasia and suppression of megakaryocyte progenitor proliferation and differentiation, as shown through in vitro cell culture. High levels of circulating thrombopoietin indicate an intact hematopoietic response to low platelet counts. Preventing hepatitis C infection and further study of direct viral effects on megakaryocytes are recommended.

1. Summary & conclusion

2. Summary & conclusion
Taken collectively, we could conclude
that,
1. Thrombocytopenia associated with
chronic hepatitis C viral infection, could
be a result of bone marrow hypoplasia
with megakaryocytic hypoplasia.

3. Summary & conclusion cont.
2. There is suppression of the
proliferative and differentiative
capabilities of megakaryocyte
progenitors as shown by results of
the in vitro short term
megakaryocytic proginetors cell
culture.

4. Summary & conclusion, cont.

3. It is also associated with high
levels of circulating
thrombopoietin which could
indicate an intact competent
hematopoietic response of the
thrombopoietin.

5. RECOMMENDATION

6. RECOMMENDATION
1. Application of all possible
preventive measures against
hepatitis C viral infection .

7. RECOMMENDATION cont.,
2. Assessment of plasma Tpo
levels may be potentially an
important diagnostic parameter
for differentiating impaired
megakaryocytepoiesis and
thrombocytopenia due to
excessive consumption.

8. RECOMMENDATION cont.,
3. Further in vitro study to
evaluate the direct
infectivity of mega-
karyocyte progenitors with
HCV.

9. RECOMMENDATION cont.,
4. Assessment of the effect
different hepatic
pathogenetic factors on
hepatic Tpo synthesis at the
mRNA translational and
transcriptional level.

12. THANK YOU

13. Thank You