Recommended
More Related Content
Similar to Chlamydia and its important species copy.pptx
Similar to Chlamydia and its important species copy.pptx (20)
Recently uploaded
Recently uploaded (20)
Chlamydia and its important species copy.pptx
- 2. Introduction • small, round to ovoid cell • Obligate intracellular bacteria • Gram-negative bacteria • Cannot synthesize ATP nor oxidize NADP, so dependent on host cell for energy
- 3. Two morphological forms - Elementary body (a small cell with an electron-dense nucleoid) - Reticulate body (a large cell which is devoid of an electron-dense nucleoid) Morphological forms
- 4. • Entry of elementary body by endocytosis • vacuole formation • reorganization into "initial or reticulate body", • Growth & Binnary fission • inclusion in host Cell cytoplasm • rupture & liberation of elementary bodies to infect new cells Replication cycle
- 5. Important species • Chlamydia trachomatis • Chlamydia psittaci • Chlamydia pneumoniae
- 6. Chlamydia Trachomatis • Eye infection Inclusion conjuctivitis • Chlamydia Trachomatis types D-K • Clinical findings ⚬ purulent discharge ⚬ Follicles in lower fornix of eye
- 7. Trachoma • Chlamydia Trachomatis types A,B and C • Clinical Findings ⚬ Lacrimation ⚬ Conjunctival hyperemia ⚬ follicular hypertrophy ⚬ corneal ulcer ⚬ mucopurulent discharge ⚬ trichiasis
- 8. Pathogenesis • Infects epithelium of conjunctiva, cornea & lacrimal apparatus • Within cytoplasm of epithelial cells. it multiplies to form basophilic inclusion bodies & produces a soluble toxin. • This toxin spread to sub-epithelial tissues producing a chronic inflammatory cellular reaction. which may be diffuse or localized to form follicles & papillae. • Healing occur by fibrous tissue formation.
- 9. Genital Chlamydial infection • Chlamydia trachomatis, types D-K. • STD • Can also be transmitted from infected mother to new born
- 10. Clinical findings • In males ⚬ painful ejaculation ⚬ epididymitis • In female ⚬ urethritis ⚬ cervicitis ⚬ salpingitis
- 11. Lymphogranuloma venereum • Chlamydia trachomatis, types LI-L3. • A sexually transmitted infection • Primarily affects Lymphatic system • stages of progression ⚬ primary ⚬ secondary ⚬ tertiary
- 12. • Clinical findings ⚬ Papule or vesicle on external genitalia, which may ulcerate ⚬ Regional lymphadenopathy & lymphadenitis. ⚬ fever ⚬ Nausea & vomiting ⚬ skin rashes
- 13. Psittacosis (parrot fever) • Cause respiratory infection in birds but can also be transmitted to humans • patchy inflammation of lungs with sharply demarcated consolidated areas having mononuclear exudate • Organisms may invade blood vessels causes enlargement & congestion of heart & liver. • Clinical Findings ⚬ fever ⚬ sore throat ⚬ Anorexia Chlamydia psittaci
- 14. • Chlamydial pneumoniae Upper and lower respiratory tract infection Chlamydia pneumonia
- 15. Diagnostic tests • Microscopy ⚬ Giemsa staining ⚬ Lugol’s Iodine staining ⚬ Immunofluorescent staining • Direct cytologic examination ⚬ DFA ⚬ EIA • PCR
- 16. Treatement Prevention and control • practice good hygiene • Avoid high risk birds • safe sexual behavious • regular health checkups
- 17. THANK YOU!