This document discusses the information and knowledge needs of nurses in the 21st century. It describes how clinical information technologies impact nursing practice and how nurses can create and derive clinical knowledge from information systems. The document outlines several challenges and strategies regarding nursing informatics and its role in leadership, clinical practice, and education. Looking to the future, it predicts that informatics competencies will be embedded in all nursing roles and that information systems will enable the delivery of safer, higher quality care through enhanced training, clinical decision support, and engagement with patients.