E-commerce companies face many challenges, including:
1) It can take 6-8 years for companies to become profitable as they focus on growing market share over profits.
2) Challenges vary depending on factors like company size, cultural differences in operating countries, and product type.
3) India is a focus for growth due to its large population, young demographics, and rising disposable incomes, but has low rates of banking, smartphone use, and internet penetration currently.