Cephalosporins are a class of β-lactam antibiotics originally derived from the fungus Acremonium. They were first isolated in 1948 from cultures of Acremonium strictum in Sardinia. Cephalosporins work by disrupting the synthesis of the bacterial cell wall. There are 5 generations of cephalosporins that have been developed with varying spectrums of activity against gram-positive and gram-negative bacteria. Cephalosporins are used therapeutically to treat a variety of bacterial infections affecting the ENT/respiratory systems, skin, blood, lungs, and other areas.
This presentation is all about introduction to antibiotics. Brief history and an overview of classification of antibiotics is discussed in this presentation.
This presentation is all about introduction to antibiotics. Brief history and an overview of classification of antibiotics is discussed in this presentation.
Pharmacology of cephalosporins, monobactums and carbapenums including their mechanism of action, indications, adverse effects.
The various generations of cephalosporins and their spectrum of action
Brief historical background & classification of antibiotics.
Antibiotics are defined as chemical substances or compounds produced by various species of microorganisms such as bacteria and fungi, which in low concentrations destroy, kill or inhibit the growth of other species of microorganisms.
Antibiotics classification Antibiotics are usually classified based on their structure, Function and/or spectrum of activity.
Dear students, you can watch the Complete chapter of antibiotics in these videos as per PCI syllabus
1)Antibiotics-History & Introduction
https://www.youtube.com/watch?v=xdKch...
2)Easy Learning Of Chapter - β-Lactam antibiotics-Cephalosporin
https://www.youtube.com/watch?v=D7b5g...
3)Learn Complete Topic -β-Lactam antibiotics(Penicillin) in Medicinal Chemistry
https://www.youtube.com/watch?v=qXQ3S...
Cephalosporins & other β lactam antibiotics & cell wall destructorsFarazaJaved
this ppt cover all 5 generations of cephalosporins and about beta lactam atibiotics and cell wall destructors data available till now. hope u ll find it useful.
Pharmacology of cephalosporins, monobactums and carbapenums including their mechanism of action, indications, adverse effects.
The various generations of cephalosporins and their spectrum of action
Brief historical background & classification of antibiotics.
Antibiotics are defined as chemical substances or compounds produced by various species of microorganisms such as bacteria and fungi, which in low concentrations destroy, kill or inhibit the growth of other species of microorganisms.
Antibiotics classification Antibiotics are usually classified based on their structure, Function and/or spectrum of activity.
Dear students, you can watch the Complete chapter of antibiotics in these videos as per PCI syllabus
1)Antibiotics-History & Introduction
https://www.youtube.com/watch?v=xdKch...
2)Easy Learning Of Chapter - β-Lactam antibiotics-Cephalosporin
https://www.youtube.com/watch?v=D7b5g...
3)Learn Complete Topic -β-Lactam antibiotics(Penicillin) in Medicinal Chemistry
https://www.youtube.com/watch?v=qXQ3S...
Cephalosporins & other β lactam antibiotics & cell wall destructorsFarazaJaved
this ppt cover all 5 generations of cephalosporins and about beta lactam atibiotics and cell wall destructors data available till now. hope u ll find it useful.
Beta lactam antibiotics, PCI syllabus for B.Pharm.Purna Nagasree K
This ppt contains beta lactum antibiotics for B.pharm people. the mechanism of action, classification was well explained. Degradations and generations of penicillins and cephalosporins was covered.
A nice introduction to Cephalosporins, how they work, the different generations, spectrum, uses, side effects, pharmacokinetics and common trade names in Egyptian market.
Third-generation beta-lactam antibiotics are effective against a wider range of microorganisms than are older antibiotics. Cefotaxime, moxalactam, cefoperazone, ceftizoxime, ceftazidime, cefsulodin, and ceftriaxone were used to treat 102 patients
To enjoy the presentation kindly download it.
For Original view, download "Poetsen One" font style from dafont website.
Here I have discussed all the first to fifth generation cephalosporins.
The cephalosporins are β-lactam antibiotics isolated from Cephalosporium spp. or prepared semisynthetically
Most of the antibiotics introduced since 1965 have been semisynthetic cephalosporins.
The current slide include the pharmacology og cephalosporins.
Contents
Introduction to Cephalosporins
Classification of Cephalosporins
Cefazolin
Cephalexin
Cefuroxime
Cefuroxime axetil
Cefotaxime
Cefixime
Cefpodoxime proxetil
Cefepime
Adverse effects of Cephalosporins
Uses of Cephalosporins
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
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The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
How to Make a Field invisible in Odoo 17Celine George
It is possible to hide or invisible some fields in odoo. Commonly using “invisible” attribute in the field definition to invisible the fields. This slide will show how to make a field invisible in odoo 17.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
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Bills have a main role in point of sale procedure. It will help to track sales, handling payments and giving receipts to customers. Bill splitting also has an important role in POS. For example, If some friends come together for dinner and if they want to divide the bill then it is possible by POS bill splitting. This slide will show how to split bills in odoo 17 POS.
This is a presentation by Dada Robert in a Your Skill Boost masterclass organised by the Excellence Foundation for South Sudan (EFSS) on Saturday, the 25th and Sunday, the 26th of May 2024.
He discussed the concept of quality improvement, emphasizing its applicability to various aspects of life, including personal, project, and program improvements. He defined quality as doing the right thing at the right time in the right way to achieve the best possible results and discussed the concept of the "gap" between what we know and what we do, and how this gap represents the areas we need to improve. He explained the scientific approach to quality improvement, which involves systematic performance analysis, testing and learning, and implementing change ideas. He also highlighted the importance of client focus and a team approach to quality improvement.
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
2. Introduction
The cephalosporins are a class of β-lactam antibiotics originally derived from the fungus Acremonium,
which was previously known as “Cephalosporium”.
3. Historical Background
The aerobic mold which yielded cephalosporin C was found in the sea near a sewage outfall in SuSiccu, by
Cagliari harbour in Sardinia (Italy), by the Italian pharmacologist Giuseppe Brotzu in 1945.Researchers at
the Sir William Dunn School of Pathology at the University of Oxford isolated cephalosporin C, which had
resistance to β-lactamases but was not sufficiently potent for clinical use.
Cephalosporin compounds were first isolated from cultures of Acremonium strictum from a sewer in
Sardinia in 1948 by Italian scientist Giuseppe Brotzu. He noticed these cultures produced substances that
were effective against Salmonella typhi, the cause of typhoid fever, which had β-lactamase. Cephalosporins
were first sold in 1964 (Cephalothin) by Eli Lilly.
4. 1945 - Cephalosporins were firstdetected in Cephalosporium acremonium
1948 - Cephalosporins are semisynthetic antibiotic derivatives ofcephalosporin C
1948 - Brotzu published his results in 1948
1964 - Alarmed by the need to keep ahead of rapidly mutating bacterialstrains, researchers since then have
developed 4 generation cephalosporins.
1971 -In January 1971Eli Lilly introduced Keflex, generic name Cephalexin
1996 -In January 1996 a progressive reintroduction of cephalosporinsincluding the novel4th
generation
cephalosporincefepime
5. 2003-In February 2003 Ranbaxy laboratories has rolled out its high-endcephalosporin orcefprozilunder the
brand name Refzil.Cephalosporins have an estimated Rs 1000-crore in India
2005 - Infact the risk that a patient with a history of penicillin allergywill experience a reaction to a first-
generation cephalosporin notmore than 0.5%, second generation cephalosporin not more than 0.2% and a
third-generation cephalosporin practicallynil in at least 25 studies
2010 -In October 2010 Ceftarolin (a fifth-generation cephalosporin) - was approved by the food and drug
administration (FDA)
6. Cephalosporins are semisynthetic derivatives of Cephalosporin C. Cephalosporin C is an analogue of 7-
aminocephalosporanic acid (7-ACA):
Cephalosporin C
8. Classification
1. First generation: First generation cephalosporins were the first cephalosporins on the market. They
have good antimicrobial activity against gram-positive bacteria but limited activity against gram-
negative species.
Gram-positive: Activity against penicillinase-producing, methicillin-susceptible staphylococci and
streptococci (though they are not the drugs of choice for such infections). No activity against methicillin-
resistant staphylococci or enterococci.
Gram-negative: Activity against Proteus mirabilis, some Escherichia coli, and Klebsiella pneumoniae,
but have no activity against Bacteroides fragilis, Pseudomonas, Acinetobacter, Enterobacter, indole-
positive Proteus, or Serratia.
12. 2. Second generation: Early second generation cephalosporins are very similar in basic structure to the
first generation.
Gram-positive: Less than first-generation.
Gram-negative: Greater than first-generation:Haemophilus influenzae, Enterobacter aerogenes and
some Neisseria + Proteus mirabilis, some Escherichia coli, and Klebsiella pneumoniae.
Cefaclor
Cefprozil
Cefamandole
Cefuroxime
Cephamycin C
Cefoxitin
Cefotetan
Cefmetazole
15. 3. Third generation:The majority of third generation cephalosporins have the aminothiazole group at
position C-7.
Gram-positive: Some members of this group have decreased activity against gram-positive
organisms.Activity against Staphylococci and Streptococci is less with the third-generation compounds
than with the first- and second-generation compounds.
Gram-negative: Third-generation cephalosporins have a broad spectrum of activity and further
increased activity against gram-negative organisms. They are also able to penetrate the central nervous
system, making them useful against meningitis caused by pneumococci, meningococci, H. influenzae,
and susceptible E. coli, Klebsiella, and penicillin-resistant N. gonorrhoeae.
20. 4. Fourth generation:The fourth generation cephalosporins have greater activity against gram-negative
bacteria than the second and third generation.This difference is attributed to them being dipolar ionic
zwitterion compounds.
Gram-positive: They are extended-spectrum agents with similar activity against Gram-positive
organisms as first-generation cephalosporins.
Gram-negative: Fourth-generation cephalosporins are zwitter-ions that can penetrate the outer
membrane of Gram-negative bacteria. They also have a greater resistance to β-lactamases than the third-
generation cephalosporins. Many can cross the blood-brain barrier and are effective in meningitis. They
are also used against Pseudomonas aeruginosa.
Cefepime
Cefpirome
Cefiderocol
22. 5. Fifth generation: These new drugs are the only β-lactam antibiotics that are effective against
methicillin-resistant-Staphylococcus-aureus (MRSA).
Ceftobiprole
Ceftaroline
Ceftozolone
Ceftobiprole Ceftaroline
24. Mechanism of action
Cephalosporins are bactericidal and are less susceptible to hydrolysis by β-lactamases compared to
penicillin antibiotics.
Cephalosporins disrupt the synthesis of the peptidoglycan layer forming the bacterial cell wall.The
peptidoglycan layer is important for cell wall structural integrity. The final transpeptidation step in the
synthesis of the peptidoglycan is facilitated by penicillin-binding proteins (PBPs). PBPs bind to the D-Ala-
D-Ala at the end of muropeptides (peptidoglycan precursors) to crosslink the peptidoglycan. Beta-lactam
antibiotics mimic the D-Ala-D-Ala site, thereby irreversibly inhibiting the PBP mediated crosslinking of the
peptidoglycan.
33. 7-Acylamino substitution
a. The addition of amino group and a hydrogen to α and α1 position produces basic compound, which is
protonated under acidic conditions of stomach. The ammonium ion improves the stability of β-lactum of
cephalosporins and make active orally. Activity against positive bacteria is increased and gram negative is
decreased by acylation of amino group.
b. When the new acyl groups are derived from carboxylic acids, it shows good spectrum of antibacterial
action for gram-positive bacteria.
c. Substitutions on the aromatic ring phenyl that increase lipophilicity provide higher gram-positive activity
and generally lower gram-negative activity.
34. d. The phenyl ring in the side chain can be replaced with other heterocycles with improved spectrum of
activity and pharmacokinetic properties; these include thiophene, tetrazole, furan, pyridine, and
aminothiazoles.
e. The L-isomer of an α-amino α1 -hydrogen derivative of cephalosphorins was 30–40 fold stable than D-
isomer. Addition of methoxy oxime to α and α1increases the stability to nearly 100-fold. The presence of
catechol grouping can also enhance activity, particularly, against Pseudomonas aeruginosa, and also retain
some gram-positive activity, which is unused for a catechol cephalosporin.
35. Modification in the C-3 substitution: The pharmacokinetic and pharmacodynamics depends on C-3
substituents. Modification at C-3 position has been made to reduce the degradation (lactone of desacetyl
cephalosporin) of cephalosporins.
a.The benzoyl ester displayers improved gram-positive activity, but lowered gram-negative activity.
b. Pyridine, imidaozle replaced acetoxy group by azide ion yields derivative with relatively low
gramnegative activity.
c. Displacement with aromatic thiols of 3-acetoxy group results in an enhancement of activity against gram-
negative bacteria with improved pharmacokinetic properties.
d. Orally active compounds are produced by replacement of acetoxy group at C-3 position with CH3 and Cl.
36. Other modifications
a. Methoxy group at C-7, shows higher resistance to hydrolysis by β-lactamase.
b. Oxidation of ring spectrum to sulphoxide or sulphone greatly diminishes or destroys antibacterial activity.
c. Replacement of sulphur with oxygen leads to oxacepam (latamoxet) with increased antibacterial activity,
because of its enhanced acylating power. Similarly, replacement of sulphur with methylene group
(loracavet) has greater chemical stability and a longer half-life.
d. The carboxyl group position-4 has been converted into ester prodrugs to increase bioavailability of
cephalosporins, and these can be given orally as well.
e. The antibacterial activity depends on the olefinic linkage at C-3 and C-4 position and their activity is lost
due to the ionization of double bond to 2nd and 3rd positions.