The presentation of celiac disease in children has changed over the past 20 years. Now, most children present later in life, around 8 years old, with subtle or non-gastrointestinal symptoms rather than classical gastrointestinal symptoms. Additionally, celiac disease is no longer primarily found in European populations, but is becoming a global issue. While a gluten-free diet can improve autoimmune conditions associated with celiac disease, it does not always prevent their development.

1. The Changing Clinical Presentation of Celiac Disease Pediatr Adolesc Med. Basel, Karger, 2008, vol 12, pp 18–22 Lebenthal E. et al. presented by: Nargess Tavakoli Guilan university of medical sciences