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‫الرحيم‬ ‫الرحمن‬ ‫هللا‬ ‫بسم‬
Catheter Access for Hemodialysis
A brief review
Dr. Ramadan Arafa; FRCPI
Physician and Nephrologist
Fujairah hospital, UAE
Vascular accesses for Hemodialysis are:
AV fistula, an AV graft, and a venous catheter
Recommendations
Renal Association 2011 guidelines
• Preferred type of vascular access
We recommend that any individual who
commences haemodialysis should do so with an
AVF as first choice, an AV graft as second choice, a
tunneled venous catheter as third choice and a non
tunneled catheter as an option of necessity. (1B)
Types of hemodialysis catheter
Catheter Kit
Tunneled Catheter Kit
Venous approach
Femoral vein catheter
Indications for Central Venous Catheterization and
the preferred insertion sites
Indications Site 1 Site 2
TPN SC IJ
Acute HDF /plasmapharesis F IJ
Emergency transveous pacemaker RIJ LIJ or SC
General purpose for drug or irritant
medications
RIJ or SC LIJ
CVP monitoring RIJ or SC LIJ
Long term hemodialysis RIJ F
• What to do if the patient has IJV,
Subclavian and femoral vein
thrombosis ???
Transhepatic vein cannulation
• 23 patients required a single transhepatic access
procedure.
• Technical success was achieved in 22 procedures.
• Functionality success was achieved in 20 patients.
Functionality failure occurred in 3 patients.
• The trans-hepatic catheters stayed in place
between 90 and 300 days. Complications occurred
in 14 patients (3 major + 11 minor).
Prosthetic axillary- axillary AVG
• Prosthetic axillary-axillary arm loop AVG for
hemodialysis (Hossam El Wakeel et al; 2013):
– The primary patency rate at 1 year was 63.4% and at 2
years was 21.8%. The secondary patency rate at 1 year
was 75.6% and at 2 years was 43.5%.
• AVG with outflow in the proximal axillary vein
(Teruya et al 2009):
– Patency rates were 78%, with mean follow-up of 16
months.
Translumbar inferior vena cava catheter
• Initially used for post bone marrow
transplantation
• Later was used as a vascular access in ESRD
patients for hemodialysis with difficult access
• A complication specific to placement of IVC
hemodialysis catheters is migration of the
catheter into the subcutaneous soft tissues,
retroperitoneum, or iliac veins
Alain Guy Assounga et al; SAMJ 2008
Goupta et al; J Am Soc Nephrol. 1995
Rajan et al; Radiographics 1998
Transthoracic SVC catheterization
• Transthoracic permanent catheter placement
is an appropriate alternative for patients in
whom traditional venous access sites are no
longer available.
Wellons et al; Journal of Vascular Surgery 2005
General rules
• If the patient has a coagulopathy, the femoral
or external jugular veins are the preferred
first site, and the internal jugulars are the 2nd
choice.
• Relative contraindications for subclavian
insertion include bilateral pulmonary
pathology, high-pressure mechanical
ventilation, and altered local anatomy.
• If one attempt at subclavian insertion has been
unsuccessful, an attempt on the opposite
subclavian is relatively contraindicated because
of the risk of bilateral pneumothorax
• If a unilateral pulmonary disease is present, SC
and IJ insertion should be done on the same
side as the affected lung.
•Avoid putting lines close to contaminated areas (eg
burns, infected tracheostomy site)
• Inexperienced operators are only allowed 2 passes
for the vein at a particular site before requesting
help
•Only insert lines with the number of lumens that
are required e.g patients requiring long-term
venous access for antibiotics only require a single
lumen
• K/DOQI Guidelines state that subclavian
vein (SCV) catheterization should be
avoided in patients with ESRD because of
the risk for central venous stenosis, with
subsequent loss of the entire ipsilateral arm
for vascular access.
• Both the National Institute of Clinical
Excellence in the UK and the USA KDOQI
recommend ultrasound guidance as the
preferred method for insertion of central
venous catheters into the internal jugular
vein
Documentation
The following must be legibly documented in
patient notes:
• Date, time
• Operator(s) and his / her assistants.
• Form of anaesthesia or use of analgesia
• Line type and indication for use
• Insertion site
• Complications recognized during insertion,
including arterial puncture
• CXR result
Risks and Precautions
EJV approach for perm. Cath insertion
Ali Akbar et al; Adv Biomedical
Research J 2014
Complications decreased over the time from
18% to 6% after 6 months
1. Bleeding:
Check the clotting screen on the day of insertion.
CVC insertion should be postponed (or done by
experienced clinicians) if the platelet count is <
50,000 or the INR is > 1.5.
2. Arterial puncture
Stop procedure and compress the site for 10
minutes by the clock (better to use US-guided
insertion)
3. Air embolism
Patient should be lying head down -15 to -20°
during SC or IJ insertion. Keep the needle hub and
catheter lumens as close to patient skin as possible.
Risks and …. continue
4. Arrythmias:
• The commonest arrhythmias noticed are
premature atrial and ventricular contractions, and
supraventricular tachyarrhythmia
• The commonest cardiac conduction abnormalities
are RBBB, LAHB and very rarely asystole.
• CHB is a well-documented complication known to
occur during catheterization of one side of the
heart when contralateral bundle branch block pre-
exists
Jain et al; IJCRI April 2011
Unnikrishnan et al; BJA 2003
Arrhythmias …. continued
• RBBB may occur in 5% of cases while CHB may
occur in 23% of cases with pre-existing LBBB
• In published cases of guide wire – induced CHB, it
was transient and most of patients recover
without the need for permanent pacing
• We have a case report has asystole which
alternates with severe bradyarrhythmia and LAHB
pattern. He did not respond to immediate
measures of atropine, adrenaline or
transcutaneous pacing. He was revived only with
transvenous pacing.
Jain et al; IJCRI April 2011
D. Morris et al; Arch of Int Med 2005
• The pathophysiology of CHB in patients with pre-
existing LBBB is not clear
• It may be due to direct impingement of the
catheter up on right bundle branch.
• Fascicular block may be due to longitudinal
dissociation of fibres in the bundle of His.
• Careful insertion of guidewire to less than 22 cm
decreases the incidence of complications by 70%.
So, it is better to consider the safe limit up to 18
cm.
Arrhythmias …. continued
Jain et al; IJCRI April 2011
Eissa et al; Anaesthesiology 1990
Wani et al; Case reports in Critical Care 2016
Baseline ECG - LBBB
Post CPR ECG - LAFB
Post pacing ECG
CXR post PPM insertion
Risks and …. continue
5. Break in sterile technique
• Re-gown if required. Replace any contaminated
equipment before continuing with the procedure
6. Pneumothorax
• If patient is at high risk of pneumothorax
because of lung hyper-expansion, the IJ site is
preferable. Check CXR post-insertion (SC or IJ)
Risks and …. continue
7. Malposition
• Check CXR post-insertion (SC and IJ only).
• Catheter tip should lie in the lower SVC
8. Thoracic duct damage
• Avoid the LIJ or LSC site if possible
9. Catheter-induced thrombosis
• Limit insertion attempts to 2 for inexperienced
clinicians
• Tip of SC or IJ CVC should lie in the lower SVC
• Any femoral CVC must be removed after 6 days
regardless of the clinical situation.
Risks and …. continue
10. Laryngeal injury
11. Guide wire embolism
Risks and …. continue
12. Catheter dysfunction:
• Kinked Catheter
• Catheter Tip in Azygos Vein
• Fibrin Sheath Formation
• Intraluminal Thrombus
• Exposed Cuff
• Catheter – related infection
Catheter – related infection
What are the interventions for CRI ?
1. Surveillance and data feed back
2. Chlorhexidine for skin antisepsis: during catheter
insertion and during dressing changes
3. Hand hygiene audits
4. Catheter care and access care observations
5. Scrub the hub
6. Patient education and engagement
7. Staff education and competency
8. Catheter reduction
9. Antimicrobial ointment or chlorhexidine sponge at
catheter exit site
Treatment of infection
• 7.4.1 Catheter exit-site infections, in the absence
of a tunnel infection, should be treated with
topical and/or oral antibiotics, ensuring proper
local exit-site care. In general, it should not be
necessary to remove the catheter.
• 7.4.2 If a patient with bacteremia is afebrile
within 48 hours and is clinically stable, catheter
salvage might be considered by using an
interdialytic antibiotic lock solution and 3 weeks
of parenteral antibiotics in appropriate situations.
A follow-up blood culture 1 week after
completion of the course of antibiotics should be
performed.
Treatment of infection … cont’d
• 7.4.3 Antibiotic lock with antibiotic to which the
organism is sensitive is indicated when follow-up
cultures indicate reinfection with the same
organism in a patient with limited catheter sites.
• 7.4.4 Short-term catheters should be removed
when infected. There is no conclusive evidence to
support a rationale for scheduled replacement
except for those in the femoral area.
KDIGO guidelines 2006
Points for discussion
1. Prophylactic vancomycin injection?
2. If yes; before or after the procedure?
3. If No; is it absolutely contraindicated?
4. Thrombolytic therapy for possible infected
catheter?
5. Thrombolytic therapy for AVG thrombosis: what
is your experience?
6. HIV cases: what is the preferred approach?
Thank you
Pneumothorax
Malposition
Kinked Catheter
Catheter Tip in Azygos Vein
Catheter tip
Catheter tip
Fibrin Sheath Formation
Intraluminal Thrombus
Exposed Cuff
Tunnel Infection
Exit Site Infection
Catheter – related infection

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Catheter access final

  • 2. Catheter Access for Hemodialysis A brief review Dr. Ramadan Arafa; FRCPI Physician and Nephrologist Fujairah hospital, UAE
  • 3. Vascular accesses for Hemodialysis are: AV fistula, an AV graft, and a venous catheter
  • 4. Recommendations Renal Association 2011 guidelines • Preferred type of vascular access We recommend that any individual who commences haemodialysis should do so with an AVF as first choice, an AV graft as second choice, a tunneled venous catheter as third choice and a non tunneled catheter as an option of necessity. (1B)
  • 9.
  • 11. Indications for Central Venous Catheterization and the preferred insertion sites Indications Site 1 Site 2 TPN SC IJ Acute HDF /plasmapharesis F IJ Emergency transveous pacemaker RIJ LIJ or SC General purpose for drug or irritant medications RIJ or SC LIJ CVP monitoring RIJ or SC LIJ Long term hemodialysis RIJ F
  • 12. • What to do if the patient has IJV, Subclavian and femoral vein thrombosis ???
  • 14. • 23 patients required a single transhepatic access procedure. • Technical success was achieved in 22 procedures. • Functionality success was achieved in 20 patients. Functionality failure occurred in 3 patients. • The trans-hepatic catheters stayed in place between 90 and 300 days. Complications occurred in 14 patients (3 major + 11 minor).
  • 15. Prosthetic axillary- axillary AVG • Prosthetic axillary-axillary arm loop AVG for hemodialysis (Hossam El Wakeel et al; 2013): – The primary patency rate at 1 year was 63.4% and at 2 years was 21.8%. The secondary patency rate at 1 year was 75.6% and at 2 years was 43.5%. • AVG with outflow in the proximal axillary vein (Teruya et al 2009): – Patency rates were 78%, with mean follow-up of 16 months.
  • 16. Translumbar inferior vena cava catheter • Initially used for post bone marrow transplantation • Later was used as a vascular access in ESRD patients for hemodialysis with difficult access • A complication specific to placement of IVC hemodialysis catheters is migration of the catheter into the subcutaneous soft tissues, retroperitoneum, or iliac veins Alain Guy Assounga et al; SAMJ 2008 Goupta et al; J Am Soc Nephrol. 1995 Rajan et al; Radiographics 1998
  • 17. Transthoracic SVC catheterization • Transthoracic permanent catheter placement is an appropriate alternative for patients in whom traditional venous access sites are no longer available. Wellons et al; Journal of Vascular Surgery 2005
  • 19. • If the patient has a coagulopathy, the femoral or external jugular veins are the preferred first site, and the internal jugulars are the 2nd choice. • Relative contraindications for subclavian insertion include bilateral pulmonary pathology, high-pressure mechanical ventilation, and altered local anatomy.
  • 20. • If one attempt at subclavian insertion has been unsuccessful, an attempt on the opposite subclavian is relatively contraindicated because of the risk of bilateral pneumothorax • If a unilateral pulmonary disease is present, SC and IJ insertion should be done on the same side as the affected lung.
  • 21. •Avoid putting lines close to contaminated areas (eg burns, infected tracheostomy site) • Inexperienced operators are only allowed 2 passes for the vein at a particular site before requesting help •Only insert lines with the number of lumens that are required e.g patients requiring long-term venous access for antibiotics only require a single lumen
  • 22. • K/DOQI Guidelines state that subclavian vein (SCV) catheterization should be avoided in patients with ESRD because of the risk for central venous stenosis, with subsequent loss of the entire ipsilateral arm for vascular access.
  • 23. • Both the National Institute of Clinical Excellence in the UK and the USA KDOQI recommend ultrasound guidance as the preferred method for insertion of central venous catheters into the internal jugular vein
  • 24. Documentation The following must be legibly documented in patient notes: • Date, time • Operator(s) and his / her assistants. • Form of anaesthesia or use of analgesia • Line type and indication for use • Insertion site • Complications recognized during insertion, including arterial puncture • CXR result
  • 26. EJV approach for perm. Cath insertion Ali Akbar et al; Adv Biomedical Research J 2014
  • 27.
  • 28. Complications decreased over the time from 18% to 6% after 6 months
  • 29. 1. Bleeding: Check the clotting screen on the day of insertion. CVC insertion should be postponed (or done by experienced clinicians) if the platelet count is < 50,000 or the INR is > 1.5. 2. Arterial puncture Stop procedure and compress the site for 10 minutes by the clock (better to use US-guided insertion) 3. Air embolism Patient should be lying head down -15 to -20° during SC or IJ insertion. Keep the needle hub and catheter lumens as close to patient skin as possible.
  • 30. Risks and …. continue 4. Arrythmias: • The commonest arrhythmias noticed are premature atrial and ventricular contractions, and supraventricular tachyarrhythmia • The commonest cardiac conduction abnormalities are RBBB, LAHB and very rarely asystole. • CHB is a well-documented complication known to occur during catheterization of one side of the heart when contralateral bundle branch block pre- exists Jain et al; IJCRI April 2011 Unnikrishnan et al; BJA 2003
  • 31. Arrhythmias …. continued • RBBB may occur in 5% of cases while CHB may occur in 23% of cases with pre-existing LBBB • In published cases of guide wire – induced CHB, it was transient and most of patients recover without the need for permanent pacing • We have a case report has asystole which alternates with severe bradyarrhythmia and LAHB pattern. He did not respond to immediate measures of atropine, adrenaline or transcutaneous pacing. He was revived only with transvenous pacing. Jain et al; IJCRI April 2011 D. Morris et al; Arch of Int Med 2005
  • 32. • The pathophysiology of CHB in patients with pre- existing LBBB is not clear • It may be due to direct impingement of the catheter up on right bundle branch. • Fascicular block may be due to longitudinal dissociation of fibres in the bundle of His. • Careful insertion of guidewire to less than 22 cm decreases the incidence of complications by 70%. So, it is better to consider the safe limit up to 18 cm. Arrhythmias …. continued Jain et al; IJCRI April 2011 Eissa et al; Anaesthesiology 1990 Wani et al; Case reports in Critical Care 2016
  • 34. Post CPR ECG - LAFB
  • 36. CXR post PPM insertion
  • 37. Risks and …. continue 5. Break in sterile technique • Re-gown if required. Replace any contaminated equipment before continuing with the procedure 6. Pneumothorax • If patient is at high risk of pneumothorax because of lung hyper-expansion, the IJ site is preferable. Check CXR post-insertion (SC or IJ)
  • 38. Risks and …. continue 7. Malposition • Check CXR post-insertion (SC and IJ only). • Catheter tip should lie in the lower SVC 8. Thoracic duct damage • Avoid the LIJ or LSC site if possible 9. Catheter-induced thrombosis • Limit insertion attempts to 2 for inexperienced clinicians • Tip of SC or IJ CVC should lie in the lower SVC • Any femoral CVC must be removed after 6 days regardless of the clinical situation.
  • 39. Risks and …. continue 10. Laryngeal injury 11. Guide wire embolism
  • 40. Risks and …. continue 12. Catheter dysfunction: • Kinked Catheter • Catheter Tip in Azygos Vein • Fibrin Sheath Formation • Intraluminal Thrombus • Exposed Cuff • Catheter – related infection
  • 41. Catheter – related infection
  • 42. What are the interventions for CRI ? 1. Surveillance and data feed back 2. Chlorhexidine for skin antisepsis: during catheter insertion and during dressing changes 3. Hand hygiene audits 4. Catheter care and access care observations 5. Scrub the hub 6. Patient education and engagement 7. Staff education and competency 8. Catheter reduction 9. Antimicrobial ointment or chlorhexidine sponge at catheter exit site
  • 43. Treatment of infection • 7.4.1 Catheter exit-site infections, in the absence of a tunnel infection, should be treated with topical and/or oral antibiotics, ensuring proper local exit-site care. In general, it should not be necessary to remove the catheter. • 7.4.2 If a patient with bacteremia is afebrile within 48 hours and is clinically stable, catheter salvage might be considered by using an interdialytic antibiotic lock solution and 3 weeks of parenteral antibiotics in appropriate situations. A follow-up blood culture 1 week after completion of the course of antibiotics should be performed.
  • 44. Treatment of infection … cont’d • 7.4.3 Antibiotic lock with antibiotic to which the organism is sensitive is indicated when follow-up cultures indicate reinfection with the same organism in a patient with limited catheter sites. • 7.4.4 Short-term catheters should be removed when infected. There is no conclusive evidence to support a rationale for scheduled replacement except for those in the femoral area. KDIGO guidelines 2006
  • 45. Points for discussion 1. Prophylactic vancomycin injection? 2. If yes; before or after the procedure? 3. If No; is it absolutely contraindicated? 4. Thrombolytic therapy for possible infected catheter? 5. Thrombolytic therapy for AVG thrombosis: what is your experience? 6. HIV cases: what is the preferred approach?
  • 46.
  • 47.
  • 48.
  • 53. Catheter Tip in Azygos Vein Catheter tip Catheter tip
  • 57. Tunnel Infection Exit Site Infection Catheter – related infection

Editor's Notes

  1. Vascular access remains a key component of hemodialysis. The ideal vascular access should provide safe and effective blood flow by enabling the removal and return of blood via an extracorporeal circuit. Vascular access should be easy to use, reliable and have minimal risk to the individual receiving haemodialysis. 
  2. Vascular access implications First of all, catheter use poses a great risk to patients. The bottom line is, catheters kill, and patients with a catheter, depending on the study, have up to double the relative risk of death. So what that means is when you choose, for whatever reason, rightly, wrongly, or because there is no choice, to get a catheter in a patient, in that patient you have increased the risk of dying as part of the contract. We know that fistulas have the lowest complication rates and require the fewest procedures. When you look, this is USRDS data, what you can see is, that although catheter procedures total are lower than grafts, look at the infection, look at the sepsis, and the cost issues. Catheters are a morbidity issue, they are a mortality issue.
  3. Now, I'm going to show you some data. Rather than go back to the series of studies from the literature I could show you, I chose to show you network data from Florida because it's stuff you haven't seen and it's not as sifted, it's not as manicured. And this looks at hospitalization in the state of Florida, Medicare hospitalization, from claims. So it's claims-based data, and what you can see is, that the folks with catheters in the first 180 days have an admission rate of 1.8 admissions, 2.9 within 365 days, 2007 and 2008. it's not very different now. You could see that the fistula patients are lower, and graft patients are in between. That's just why data is not controlled, but that's what you see, that's what you know from your hospital.
  4. End-stage renal disease mortality by access type And if you look at mortality, same story. Look at the mortality rate in patients with catheters. First 180 days, first year. Huge mortality relative to these other folks. Now, patients are different, but in studies that Michael Landt has done and numerous other groups have done, every study done shows that catheters, independent of patient characteristics, increase your mortality risk. End of story.