Although large efforts are spent for creating fistula as the primary access, use of Hemodialysis Vascular catheters are still the major access on the first Hemodialysis session and after 4 month whether we would like it or not.
"USRDS 2013"
This procedure is knowledge required for the dialysis, in this PPT include introduction, definition, indication, Advantages, Disadvantages, Nursing care and complication of Arteriovenous graft.
Although large efforts are spent for creating fistula as the primary access, use of Hemodialysis Vascular catheters are still the major access on the first Hemodialysis session and after 4 month whether we would like it or not.
"USRDS 2013"
This procedure is knowledge required for the dialysis, in this PPT include introduction, definition, indication, Advantages, Disadvantages, Nursing care and complication of Arteriovenous graft.
Joel Arudchelvam
Definition
Donor types
HISTORY OF TRASNPLANTATION in Sri Lanka
Transplantation procedure
Organ preservation
BASIC COMPONENTS OF PRESERVATION SOLUTIONS
A detailed description of diagnosing and managing peritonitis and catheter-related infections in peritoneal dialysis patients.
A practical guide for Nephrologists and health care professionals.
An educational material describing the Indications for Tracheostomy-Complications of Tracheostomy-Timing of Tracheostomy-Tracheostomy Technique-Tracheostomy Decannulation and types of Tracheostomy Tubes.
Joel Arudchelvam
Definition
Donor types
HISTORY OF TRASNPLANTATION in Sri Lanka
Transplantation procedure
Organ preservation
BASIC COMPONENTS OF PRESERVATION SOLUTIONS
A detailed description of diagnosing and managing peritonitis and catheter-related infections in peritoneal dialysis patients.
A practical guide for Nephrologists and health care professionals.
An educational material describing the Indications for Tracheostomy-Complications of Tracheostomy-Timing of Tracheostomy-Tracheostomy Technique-Tracheostomy Decannulation and types of Tracheostomy Tubes.
An educational material describing the Indications for Tracheostomy-Complications of Tracheostomy-Timing of Tracheostomy-Tracheostomy Technique-Tracheostomy Decannulation and types of Tracheostomy Tubes. Quite useful for general surgery residents and medical students and also general physicians.
An educational material describing the Indications for Tracheostomy-Complications of Tracheostomy-Timing of Tracheostomy-Tracheostomy Technique-Tracheostomy Decannulation and types of Tracheostomy Tubes
This slide will provide illustrative information regarding coronary angioplasty . It also focus on practical area knowledge of cardiac catheterization which one should focus while caring patient with coronary angioplasty.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
2. Catheter Access for Hemodialysis
A brief review
Dr. Ramadan Arafa; FRCPI
Physician and Nephrologist
Fujairah hospital, UAE
3. Vascular accesses for Hemodialysis are:
AV fistula, an AV graft, and a venous catheter
4. Recommendations
Renal Association 2011 guidelines
• Preferred type of vascular access
We recommend that any individual who
commences haemodialysis should do so with an
AVF as first choice, an AV graft as second choice, a
tunneled venous catheter as third choice and a non
tunneled catheter as an option of necessity. (1B)
11. Indications for Central Venous Catheterization and
the preferred insertion sites
Indications Site 1 Site 2
TPN SC IJ
Acute HDF /plasmapharesis F IJ
Emergency transveous pacemaker RIJ LIJ or SC
General purpose for drug or irritant
medications
RIJ or SC LIJ
CVP monitoring RIJ or SC LIJ
Long term hemodialysis RIJ F
12. • What to do if the patient has IJV,
Subclavian and femoral vein
thrombosis ???
14. • 23 patients required a single transhepatic access
procedure.
• Technical success was achieved in 22 procedures.
• Functionality success was achieved in 20 patients.
Functionality failure occurred in 3 patients.
• The trans-hepatic catheters stayed in place
between 90 and 300 days. Complications occurred
in 14 patients (3 major + 11 minor).
15. Prosthetic axillary- axillary AVG
• Prosthetic axillary-axillary arm loop AVG for
hemodialysis (Hossam El Wakeel et al; 2013):
– The primary patency rate at 1 year was 63.4% and at 2
years was 21.8%. The secondary patency rate at 1 year
was 75.6% and at 2 years was 43.5%.
• AVG with outflow in the proximal axillary vein
(Teruya et al 2009):
– Patency rates were 78%, with mean follow-up of 16
months.
16. Translumbar inferior vena cava catheter
• Initially used for post bone marrow
transplantation
• Later was used as a vascular access in ESRD
patients for hemodialysis with difficult access
• A complication specific to placement of IVC
hemodialysis catheters is migration of the
catheter into the subcutaneous soft tissues,
retroperitoneum, or iliac veins
Alain Guy Assounga et al; SAMJ 2008
Goupta et al; J Am Soc Nephrol. 1995
Rajan et al; Radiographics 1998
17. Transthoracic SVC catheterization
• Transthoracic permanent catheter placement
is an appropriate alternative for patients in
whom traditional venous access sites are no
longer available.
Wellons et al; Journal of Vascular Surgery 2005
19. • If the patient has a coagulopathy, the femoral
or external jugular veins are the preferred
first site, and the internal jugulars are the 2nd
choice.
• Relative contraindications for subclavian
insertion include bilateral pulmonary
pathology, high-pressure mechanical
ventilation, and altered local anatomy.
20. • If one attempt at subclavian insertion has been
unsuccessful, an attempt on the opposite
subclavian is relatively contraindicated because
of the risk of bilateral pneumothorax
• If a unilateral pulmonary disease is present, SC
and IJ insertion should be done on the same
side as the affected lung.
21. •Avoid putting lines close to contaminated areas (eg
burns, infected tracheostomy site)
• Inexperienced operators are only allowed 2 passes
for the vein at a particular site before requesting
help
•Only insert lines with the number of lumens that
are required e.g patients requiring long-term
venous access for antibiotics only require a single
lumen
22. • K/DOQI Guidelines state that subclavian
vein (SCV) catheterization should be
avoided in patients with ESRD because of
the risk for central venous stenosis, with
subsequent loss of the entire ipsilateral arm
for vascular access.
23. • Both the National Institute of Clinical
Excellence in the UK and the USA KDOQI
recommend ultrasound guidance as the
preferred method for insertion of central
venous catheters into the internal jugular
vein
24. Documentation
The following must be legibly documented in
patient notes:
• Date, time
• Operator(s) and his / her assistants.
• Form of anaesthesia or use of analgesia
• Line type and indication for use
• Insertion site
• Complications recognized during insertion,
including arterial puncture
• CXR result
29. 1. Bleeding:
Check the clotting screen on the day of insertion.
CVC insertion should be postponed (or done by
experienced clinicians) if the platelet count is <
50,000 or the INR is > 1.5.
2. Arterial puncture
Stop procedure and compress the site for 10
minutes by the clock (better to use US-guided
insertion)
3. Air embolism
Patient should be lying head down -15 to -20°
during SC or IJ insertion. Keep the needle hub and
catheter lumens as close to patient skin as possible.
30. Risks and …. continue
4. Arrythmias:
• The commonest arrhythmias noticed are
premature atrial and ventricular contractions, and
supraventricular tachyarrhythmia
• The commonest cardiac conduction abnormalities
are RBBB, LAHB and very rarely asystole.
• CHB is a well-documented complication known to
occur during catheterization of one side of the
heart when contralateral bundle branch block pre-
exists
Jain et al; IJCRI April 2011
Unnikrishnan et al; BJA 2003
31. Arrhythmias …. continued
• RBBB may occur in 5% of cases while CHB may
occur in 23% of cases with pre-existing LBBB
• In published cases of guide wire – induced CHB, it
was transient and most of patients recover
without the need for permanent pacing
• We have a case report has asystole which
alternates with severe bradyarrhythmia and LAHB
pattern. He did not respond to immediate
measures of atropine, adrenaline or
transcutaneous pacing. He was revived only with
transvenous pacing.
Jain et al; IJCRI April 2011
D. Morris et al; Arch of Int Med 2005
32. • The pathophysiology of CHB in patients with pre-
existing LBBB is not clear
• It may be due to direct impingement of the
catheter up on right bundle branch.
• Fascicular block may be due to longitudinal
dissociation of fibres in the bundle of His.
• Careful insertion of guidewire to less than 22 cm
decreases the incidence of complications by 70%.
So, it is better to consider the safe limit up to 18
cm.
Arrhythmias …. continued
Jain et al; IJCRI April 2011
Eissa et al; Anaesthesiology 1990
Wani et al; Case reports in Critical Care 2016
37. Risks and …. continue
5. Break in sterile technique
• Re-gown if required. Replace any contaminated
equipment before continuing with the procedure
6. Pneumothorax
• If patient is at high risk of pneumothorax
because of lung hyper-expansion, the IJ site is
preferable. Check CXR post-insertion (SC or IJ)
38. Risks and …. continue
7. Malposition
• Check CXR post-insertion (SC and IJ only).
• Catheter tip should lie in the lower SVC
8. Thoracic duct damage
• Avoid the LIJ or LSC site if possible
9. Catheter-induced thrombosis
• Limit insertion attempts to 2 for inexperienced
clinicians
• Tip of SC or IJ CVC should lie in the lower SVC
• Any femoral CVC must be removed after 6 days
regardless of the clinical situation.
42. What are the interventions for CRI ?
1. Surveillance and data feed back
2. Chlorhexidine for skin antisepsis: during catheter
insertion and during dressing changes
3. Hand hygiene audits
4. Catheter care and access care observations
5. Scrub the hub
6. Patient education and engagement
7. Staff education and competency
8. Catheter reduction
9. Antimicrobial ointment or chlorhexidine sponge at
catheter exit site
43. Treatment of infection
• 7.4.1 Catheter exit-site infections, in the absence
of a tunnel infection, should be treated with
topical and/or oral antibiotics, ensuring proper
local exit-site care. In general, it should not be
necessary to remove the catheter.
• 7.4.2 If a patient with bacteremia is afebrile
within 48 hours and is clinically stable, catheter
salvage might be considered by using an
interdialytic antibiotic lock solution and 3 weeks
of parenteral antibiotics in appropriate situations.
A follow-up blood culture 1 week after
completion of the course of antibiotics should be
performed.
44. Treatment of infection … cont’d
• 7.4.3 Antibiotic lock with antibiotic to which the
organism is sensitive is indicated when follow-up
cultures indicate reinfection with the same
organism in a patient with limited catheter sites.
• 7.4.4 Short-term catheters should be removed
when infected. There is no conclusive evidence to
support a rationale for scheduled replacement
except for those in the femoral area.
KDIGO guidelines 2006
45. Points for discussion
1. Prophylactic vancomycin injection?
2. If yes; before or after the procedure?
3. If No; is it absolutely contraindicated?
4. Thrombolytic therapy for possible infected
catheter?
5. Thrombolytic therapy for AVG thrombosis: what
is your experience?
6. HIV cases: what is the preferred approach?
Vascular access remains a key component of hemodialysis. The ideal vascular access should provide safe and effective blood flow by enabling the removal and return of blood via an extracorporeal circuit. Vascular access should be easy to use, reliable and have minimal risk to the individual receiving haemodialysis.
Vascular access implicationsFirst of all, catheter use poses a great risk to patients. The bottom line is, catheters kill, and patients with a catheter, depending on the study, have up to double the relative risk of death. So what that means is when you choose, for whatever reason, rightly, wrongly, or because there is no choice, to get a catheter in a patient, in that patient you have increased the risk of dying as part of the contract. We know that fistulas have the lowest complication rates and require the fewest procedures. When you look, this is USRDS data, what you can see is, that although catheter procedures total are lower than grafts, look at the infection, look at the sepsis, and the cost issues. Catheters are a morbidity issue, they are a mortality issue.
Now, I'm going to show you some data. Rather than go back to the series of studies from the literature I could show you, I chose to show you network data from Florida because it's stuff you haven't seen and it's not as sifted, it's not as manicured. And this looks at hospitalization in the state of Florida, Medicare hospitalization, from claims. So it's claims-based data, and what you can see is, that the folks with catheters in the first 180 days have an admission rate of 1.8 admissions, 2.9 within 365 days, 2007 and 2008. it's not very different now. You could see that the fistula patients are lower, and graft patients are in between. That's just why data is not controlled, but that's what you see, that's what you know from your hospital.
End-stage renal disease mortality by access typeAnd if you look at mortality, same story. Look at the mortality rate in patients with catheters. First 180 days, first year. Huge mortality relative to these other folks. Now, patients are different, but in studies that Michael Landt has done and numerous other groups have done, every study done shows that catheters, independent of patient characteristics, increase your mortality risk. End of story.