The document provides 5 tips for using Cassandra and DSE: 1) Data modeling best practices to avoid secondary indexes, 2) Understanding compaction choices like size-tiered, leveled, and date-tiered and their use cases, 3) Common mistakes in proofs-of-concept like testing on different hardware and empty nodes, 4) Hardware recommendations like using moderate sized nodes with SSDs, and 5) Anti-patterns like loading large batches of data and modeling queues with improper partitioning.