The document discusses blood flow regulation mechanisms, detailing local regulations that maintain constant flow in tissues via arteriolar adjustments and systemic regulations that allow organ-specific blood supply control. It explains acute regulations including myogenic responses, metabolites, and hormones, along with long-term adaptations like angiogenesis for restoring flow in response to ischemia. Additionally, it mentions hormonal, chemical, and neural regulators in systemic mechanisms.

2. By
MNR Medical College & Hospital, Sangareddy

3. • Types of regulations
• Types of local regulations
• Systemic regulatory mechanisms

5. • Maintains adequate blood flow to organs like heart
and brain while others receive less flow by altering
the diameter of arterioles by pre capillary
sphincter.

6. 1. LOCAL REGULATORY MECHANISMS:
Available locally within a tissue or organ
maintain constant blood flow by arteriolar and
precapilary sphincters.
2. SYSTEMIC REGULATORY MECHANISM

7. Some organs have the capacity to regulate their
own supply depending on the requirements is
referred as auto regulation.
E.g.., heart, kidney, brain and skeletal muscles.

8. 1. ACUTE/ SHORT TERM REGULATION– acts
immediately is of 3 types again.
i. Myogenic Principle
ii. Local metabolites
iii. Local hormones
LONG TERM REGULATION

11. SYMPATHETIC DISCHARGE @1 IMP/SEC CAUSES
STRECH OF VESSEL WALL LEADS TO
CONTRACTION OF SMOOTH MUSCLE.

15. When the exiting vasculature is
unable to meet the blood flow
requirements of the organ, the
growth of new vasculature occurs
called Angiogenesis. It is seen in
growing organs/ organs suffering
from ischaemia.

16. Which causes sprouting of new vessels from either
venule/ capillaries which restores the blood flow
depending upon the need.

17. B. SYSTEMIC REGULATORY
MECHANISM

18. 1. HORMONAL/ CHEMICAL:
2. NEURAL REGULATORY MECHANISMS