This document discusses buccal drug delivery systems (BDDS), which deliver drugs through the buccal mucosa in the mouth. It notes that BDDS avoids first-pass metabolism, offers a large surface area and good patient compliance compared to other routes. Various BDDS formats are described, including buccal tablets, patches, films and hydrogels. Key factors like mucus, bioadhesion and drug release kinetics are also summarized. Evaluation tests for BDDS include thickness measurements, swelling study, surface pH, weight uniformity and in vitro drug release.

1. BUCCAL DRUG
DELIVERY SySTEM
PRESENTED BY,
YOGITA RAYATE
M.PHARM FIRST YEAR
DEPT. OF PHARMACEUTICS
R.C.P. KASEGAON
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2. What is BDDS???
 Delivery of drug through Buccal mucosa of
oral cavity is called BDDS. Buccal mucosa
lines the inner region of cheeks.
 In biological term, the product is placed
between upper gingiva (gums) & cheek to
treat local & systemic conditions.
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3.  Avoids 1 st pass metabolism
 Avoids acid/Enzyme metabolism
 Permeation is faster with respect to Skin &
TDDS
 Large surface area with respect to sub-lingual
mucosa
 Good patient compliance with respect to
parental
 Easy administration & removal in case of
toxicity.
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4.  Drugs with bitter taste or irritant to mucosa
or having noxious smell
 Not for children
 Eating & drinking difficulty
 Salivary erosion & it may enter GIT
 Less surface area than skin
 Drugs unstable at Buccal pH(6.5 to 7)
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6.  The cells of the oral epithelia are surrounded
by an intercellular ground substance, mucus.
 The oral cavity is marked by the presence of
saliva produced by the salivary glands.
 Mucus which is secreted by the major and
minor salivary glands as part of saliva.
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7. • Protective fluid for all tissues of the oral cavity
• To hydrate oral mucosal dosage forms
 Role of Mucus
• Bioadhesion or mucoadhesive drug delivery systems
• Made up of proteins and carbohydrates
• Lubrication
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8.  The term bioadhesion is commonly defined as
adhesion between two materials where at least
one of the material is of biological origin.
 When adhesion is restricted to mucus layer lining
of the mucosal surface, then it is known as
Mucoadhesion .
 Generally mechanism of mucoadhesion divided
into 2 steps-1.contact stage2.consolidation stage
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10. 1) MATRIX TYPE.
-CONVENTIONAL BUCCAL TABLETS.
2) RESERVIOUR TYPE.
-BUCCAL PATCHES
3)BUCCAL FILMS.
4) BUCCAL MUCOADHESIVE HYDROGEL.
5) BUCCAL SPRAY.
6)FAST DISSOLVING BUCCAL TABLETS.
7) BUCCAL WAFERS.
8) BUCCAL MICROSPHERE.
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12.  FAST DISSOLVING TABLETS-REQUIREMENTS
1.It requires no water for oral administration
Yet dissolves/disintegrates into mouth
2.It has a pleasant mouth feel .
3.Taste masking property
4.It is less friable and harder.
5.It leaves negligible or no residue in mouth
after administration.
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13. Easy to adminitration to patients who cannot swallow the
tablets .
It gives accurate dosing as compared to liquid
formulations.
Rapid absorption so give rapid onset of action.
Pregastric absorption can result in improved
bioavailability.
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14.  Buccal adhesive patches are modified release
dosage form that have potential to provide
controlled drug delivery from 1 to 24 hrs .
 They adhere to buccal mucosa for extended
period of time.
 They may be
 -Unidirectionally.
 -bidirectionally.
 -multidirectionally.
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15.  Thickness measurements
 Swelling study
 Surface pH
 Weight uniformity
 Folding Endurance
 In vitro drug release
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