A sharp reduction in population size due to environmental or human factors can lead to a founder effect or bottleneck effect. When a new population is established by a small number of individuals from a larger population due to migration or other reasons, it results in increased homozygosity, reduced genetic variation, and decreased heterozygosity in the new population compared to the original population. Both founder effect and bottleneck effect have similar results such as increased similarities between individuals and harmful alleles becoming fixed in the new population.