This document describes a hyaluronic acid-based sterile solution intended for intravesical application to temporarily protect and regenerate the urinary bladder mucosa. It contains hyaluronic acid derived from non-animal sources, which acts as a protector of the bladder and urethra intercellular matrix. Clinical studies showed high response rates of over 70% for indications like cystitis, interstitial cystitis, and radiation cystitis. The solution is administered intravesically once a week for 4-12 weeks and works by forming a viscous elastic film on the bladder surface to act as a barrier and promote healing.
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Infection Prevention in Dietary Department
Dr. NAHLA ABDEL KADERوMD, PhD.
INFECTION CONTROL CONSULTANT, MOH
INFECTION CONTROL CBAHI SURVEYOR
Infection Control Director, KKH.
Infection Control Guidelines for Nutrition Services [compatibility mode]drnahla
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Infection Prevention in Dietary Department
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INFECTION CONTROL CONSULTANT, MOH
INFECTION CONTROL CBAHI SURVEYOR
Infection Control Director, KKH.
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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
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The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
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STERILIZATION AND DISINFECTION IN A DENTAL CLINIC pptVineetha K
One of the basic things you need to know before starting a dental clinic. This presentation covers the basics of sterilization and disinfection in a dental setting.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Sterilisation /certified fixed orthodontic courses by Indian dental academy Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and offering a wide range of dental certified courses in different formats.
Indian dental academy provides dental crown & Bridge,rotary endodontics,fixed orthodontics,
Dental implants courses.for details pls visit www.indiandentalacademy.com ,or call
0091-9248678078
Infection Control Guidelines for Dental Clinics [compatibility mode]drnahla
Infection Control Guidelines for Dental Clinics
Infection Prevention in Dental Clinics
Dr. Nahla Abdel Kader.MD, PhD. Infection Control Consultant, MOH Infection Control Surveyor, CBAHI Infection Control Director,KKH.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
STERILIZATION AND DISINFECTION IN A DENTAL CLINIC pptVineetha K
One of the basic things you need to know before starting a dental clinic. This presentation covers the basics of sterilization and disinfection in a dental setting.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Hyaluronic acid retains water like a sponge and has the ability to absorb a thousand times more than its own weight and plays an important role in tissue hydration, lubrication and cellular function. In short, it is an excellent skin moisturizer.
production and information on Hyaluronic acid.Riddhi Karnik
history and information about hyaluronic acid its Production of hyaluronic acid. the traditional way and by genetically modifying organisms.source used is molecular biotechnology 4th edition by GICK.
OBJECTIVES
Up on completion to this presentation you will be able to:
know about H pylori definition and background
Know diagnostic method of H pylori
List available serological test for H pylori with their:-
Intended use
Principle
Precaution
Limitation
Interpretation and
Quality Control
Introduction
Most common chronic bacterial infection in world. Key constituent of human micro biome.
Gram negative Spiral shape
Multiple unipolar flagella – moves freely
Produces urease
Micro-aerophillic
3 μm long with a diameter of about 0.5 μm
More common in low socioeconomic status
Humans are major reservoir Housing density, crowded conditions in the home, number of siblings, sharing a bed, and lack of hot running water
Ph-responsive Hydrogel Loaded With Insulin As A Bioactive Dressing For Enhanc...Snehankit Gurjar
The multifunctional hydrogel is composed of N-carboxyethyl chitosan (N-chitosan) and adipic acid dihydrazide (ADH), which are crosslinked in situ by hyaluronic acid–aldehyde (HA-ALD).
Such self-healing and injectable properties are particularly appealing for skin wound repair because they help reduce gel fragmentation and integrate ruptured gels at the target site, even after external mechanical destruction, and hence can continuously support skin wound healing.
CASE REPORT ON osteomyelitis.
Osteomyelitis (Femur debridement & Bone cement Spacer with External fixator).
Femur Deridement-
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Osteomyelitis: Osteomyelitis is an infection in a bone. Infections can reach a bone by traveling through the bloodstream or spreading from nearby tissue. Infections can also begin in the bone itself if an injury exposes the bone to germs.
Infection control in critical care unitAlphyThomas9
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A Brief Introduction to Ulcers: What are ulcers, its causes, and symptoms. Classification of Antiulcer drugs and their adverse effects.
List of all the screening models available for Antiulcer drugs.
Few of the models are explained with their Principle, procedures, Evaluation, and assessment.
ANY WASTE GENERATED DURING THE DIAGNOSIS, TREATMENT OR IMMUNIZATION OF HUMA...ssuser3155141
BIOMEDICAL WASTE
IS DEFINED AS
“ANY WASTE GENERATED DURING
THE DIAGNOSIS, TREATMENT
OR IMMUNIZATION OF HUMANS
OR ANIMALS OR IN RESEARCH
ACTIVITIES PERTAINING THERTO
OR IN THE
PRODUCTION OR
TESTING OF BIOLOGI
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
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Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
2. Hyaluronic acid-based sterile solution
for intravesical application
Colourless clear viscous gel
of hyaluronic acid of non-animal
origin /sterile, apyrogenic,
with physiological values of pH/
Viscoelastic protector
of intercellular matrix
of vesical and urethral
urothelium
50 ml80 mg
Mechanical action:
barrier/lubrication
Humidifying: high extent of water
binding
Healing properties: normalisation
of cellular migration and proliferation
Filling the spatial defects
PROPERTIES
hyaluronic acid-based sterile solution for intravesical application
3. Temporary protection and regeneration
of urinary bladder mucosa in different
procedures
/cystoscopy, radiation therapy, etc./
Chronic/recurring cystitis
Interstitial cystitis
Hyperactive urinary bladder
Cystitis-mediated urinary
retention or tumours
Radiation cystitis
INDICATIONS Empty the urinary bladder prior to admini-
stration of INSTYLAN
The procedure should be performed by a specially
trained physician in a properly equipped room and
in strict adherence to all aseptic precautions
INSTYLAN is administered intravesically once a week
The treatment course includes 4-12 instillations
The temperature of INSTYLAN solution should be not
less than 20°С
Retain INSTYLAN in the urinary bladder for at least 30 min
MODE OF
APPLICATION
hyaluronic acid-based sterile solution for intravesical application
4. SAFETY
Clinical studies have demonstrated a high incidence
of objective responses in intravesical application
of hyaluronic acid /HA/
EFFICACY
Clinical studies have demonstrated high rates of
objective response in intravesical application of /HA/
Objective response rates in clinical studies with intravesical
application of hyaluronic acid
Kallestrup Leppilahti Morales Riedl Sánchez
Macías
100
75
50
25
0
%
86%
68%
73% 71% 70%
REGENERATION OF THE MUCOUS MEMBRANE
OF THE URINARY BLADDER
Hyaluronic acid plays a key role in restoring the GAG layer and produces its effect in the submucosa,
exactly where the process of epithelial regeneration initiates
Destroyed condition Partially restored condition Restored condition
5. CLINICAL STUDIES*
Painful bladder syndrome /PBS/ interstitial cystitis /IC/
Author
Morales, et al.
Kallestrup, et al.
Leppilahti, et al.
Daha, et al.
Gupta, et al.
Sánchez macías, et al.
Ahmad, et al.
Riedl, et al.
TOTAL
The number
of patients
25
20
11
48
36
21
23
121
305
The percentage of patients
with objective responses
71
65
64
89
55
70
74
84
The number of patients with
objective responses
17
13
7
43
20
15
17
103
220
Year
1996
2005
2002
2005
2005
2005
2008
2008
Radiation cystitis /RC/
Author
Delgado et al.
Diamantopoulos et al.
Gonzalez Patiño et al.
TOTAL
The number
of patients
45
20
14
78
The percentage of patients
with objective responses
nd
80
nd
Year
2003
2004
2008
Recurrent bacterial cystitis
Author
Constantinides, et al.
Lianos, et al.
Lipovac, et al.
The number
of patients
40
20
20
The percentage of patients
with objective responses
nd
70
nd
Year
2004
2005
2007
nd=nodata
*Thebelowlistincludesthenamesofclinicalstudiesthatwerepublishedand/orpresented
atscientificcongresses/meetings
6. QUALITATIVE COMPOSITION.
Sodium hyaluronate. Excipients: water for injection,
sodium chloride, phosphate buffer.
Classification of the product. Medical device – sterilized
and pyrogen-free – Class IIa.
PACKAGE. 50 ml pre-filled disposable plastic bag which
contains 0.16% (80 mg/50 ml) of hyaluronic acid solution.
Each package contains: 1 plastic bag containing INSTYLAN
sterile solution. The medical device has been sterilized by
steam sterilization.
INDICATIONS. INSTYLAN is intended for irrigation into
bladder cavity that provides the formation of a viscous
elastic film on the surface of mucous layer to:
• protecting it from external effects during various
surgeries (ureteroscopy, cystoscopy, transurethral
resection of adenoma and radiation therapy of lesser
pelvis organs, etc),
• protect it from the harmful impact of bladder content
(urina) in case of injury or from inflammation of the
mucous layer of the bladder, like cystitis.
INSTYLAN is intended for irrigation of the bladder when
using a urological catheter. The irrigation provides
temporary protection and restoration of bladder mucous
layer during various surgeries (urethra cystoscopy,
radiation therapy, etc).
WARNINGS AND SPECIAL PRECAUTIONS FOR USE
• Do not use if the solution is not transparent and
colorless.
• Do not use if the packaging has been opened or is
damaged.
• The product must be used immediately after opening.
• The product is intended for single use. After use, the
unused product is no longer sterile. Do not use product
residuals;
• Do not reuse. Once the product has been used for the
first time, any residuals of the product are not suitable
for the repeated use as the product is no longer sterile.
• Do not resterilize. Repeated sterilization may cause
cross-contamination.
• Do not freeze.
• The product must not be administered orally.
SPECIAL WARNING
• Do not use the solution in patients with known
hypersensitivity to hyaluronic acid, or those with a
history of allergic reactions to any component of the
product.
• Irrigation into the bladder should be provided by a
trained medical specialist in specialized premise with
appropriate equipment and aseptic conditions.
• Do not inject the solution into blood vessels.
• Do not use the product with pregnant or lactating
woman, or children.
ADVERSE REACTIONS AND SIDE EFFECTS. None.
HOW TO USE
• Check package integrity before use.
• Check the expiration date indicated on the bag. Do not
use after the expiry date.
• Take one of the plastic bags containing INSTYLAN
Solution.
• Make sure that the bladder of the patient has been
previously emptied
• Remove the cap
• Irrigate the patient`s bladder using an urological
catheter.
For cystitis treatments: it is suggest that the sterile
solution INSTYLAN is used weekly for the first month and
with less frequency in the following months.
The frequency of use of sterile solution INSTYLAN must
be determined by the doctor who established the
treatment.
SHELF LIFE. 2 years in an intact package.
HOW TO STORE. Store at temperatures between 5°C
to 30°C (inclusive), away from direct light and heat, in the
adequately sealed packaging. The expiry date is applied to
the products which are correctly stored in an intact
package.
DISPOSAL. The product must be disposed of in
accordance with the applicable laws on medical waste.
1936
REFERENCES.
1. Miodosky et al. Treatment of post-hematopoietic stem
cell transplantation hemorrhagic cystitis with
intravesical sodium hyaluronate. Bone Narrow
Transplantation 2006; 38,507-11.
2. Monheit et al. Hyaluronic acid fillers. Dermatologic
Therapy 2006, Vol.19, 141-150.
3. Kallestrup et al. Treatment of Interstitial Cystitis with
Cystistat: A Hyaluronic Acid product. Scan J Ural & Neph,
2005; 39: 143-147.
4. Leppilahti et al. Effect of diagnostic hydrodistension
and four intravesical hyaluronic acid instillations on
bladder ICAM-1 intensity and association of ICAM-1
intensity with clinical response in patients with
interstitial cystitis, Urol 60:46-51, 2002.
5. Morales et al. Intravesical hyaluronic acid in the
treatment of refractory interstitial cystitis. J Urol 1996
Jul;156(1):45-8
6. Riedl et al. Hyaluronan treatment of interstitial
cystitis/painful bladder syndrome. Int. Urogynecol J
Pelvic Floor Dysfunct 2008 May; 19(5): 717-21.
7. J. Sanchez Macias et al. Bladder instillations with
Hyaluronic Acid in the treatment of Interstitial Cystitis.
Our experience. Abstract presented at the 70th National
Congress of Urology, Spain 2005
8. Daha et al. Is a Maximal Bladder Capacity of >400 cc an
Automatic Exclusion Criteria for Interstitial Cystitis?
2002 SIU.
9. Gupta et al. The potassium sensitivity test: a predictor
of treatment response in interstitial cystitis. BJU
International, Volume 96, Iss 7, November 2005,
1063-1066.
10. Ahmad et al. Sequential hydrodistension and
intravesical instillation of hyaluronic acid under general
anaesthesia for treatment of refractory interstitial
cystitis : a pilot study. Int Uroynecol J Pelvic Floor
Dysfunct 2008 Apr 19 (4) : 543-546
11. Constantinides et al. Prevention of recurrent bacterial
cystitis by intravesical administration of Hyaluronic
Acid: a pilot study BJU International 2004;93,1262-1266.
12. Lianos E. et al. Effects of intravesical sodium
hyaluronate on vesical mucosa in recurrent chronic
bacterial cystitis. Journal of Endourology, Jul 2005, Vol.
19, No. supplement 1: p1-p121
13. Lipovac et al. Prevention of recurrent bacterial urinary
treatment by intravesical instillation of hyaluronic acid.
International Journal of Gynecology and Obstetrics,
March 2007;96(3): 192-5.
14. Delgado et al. HA in the prevention of RC cystitis.
ASCO 2003.
15. Diamantopoulos et al. Use of sodium hyaluronate in
patients suffering from post-radiation cystitis. ESTRO,
October 2004.
16. Riedl et al. Hyaluronan treatment of interstitial
cystitis/painful bladder syndrome. Int. Urogynecol J
Pelvic Floor Dysfunct 2008 May; 19(5): 717-21.
DIACO Biofarmaceutici S.R.L.
Via Flavia 124, 34147 Trieste, Italy
www.diaco.it
hyaluronic acid-based sterile solution
for intravesical application