Hyaluronic Acid Presentation

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dlwilson

Technology Health & Medicine

Encapsulation of Cells in Hyaluronic Acid as a Means of Cell Delivery Daniel Wilson, 11/15/2006

What is a cell delivery system? ,[object Object],[object Object],[object Object],Polyester scaffold http://www.cbmm.lodz.pl/res/sppb_big2.jpg

Why Use Injectable Hydrogels as a Delivery Mechanism? ,[object Object],[object Object],[object Object],[object Object],[object Object],http://www.wwu.edu/depts/healthyliving/PE511info/arthritis/oatreatment.htm

Pure HA? ,[object Object],[object Object],[object Object],1 Anna Gutowska, Gyeongmoon Jeong, Marek Jasionowski. “Injectable Gels for Tissue Engineering.” The Anatomical Record 263 (2001):342–349 2 Xiao Zheng Shu, Kaustabh Ghosh, Yanchun Liu, Fabio S. Palumbo3 Yi Luo, Richard A. Clark, Glenn D. Prestwich. “Attachment and spreading of fibroblasts on an RGD peptide–modified injectable hyaluronan hydrogel.” Journal of Biomedical Materials Research. Part A. 63(2) (2004): 365-75.

Alternative HA-derived Cell Delivery Systems ,[object Object],[object Object],[object Object],“ Fabrication of Hyaluronic Acid Hydrogel Beads for Cell Encapsulation.” Biotechnol. Prog. 2006, 22, 297-302 “ Electrospun three-dimensional hyaluronic acid nanofibrous scaffolds.” Biomaterials 27 (2006): 3782–3792

RGD peptide-modified injectable HA hydrogels ,[object Object],[object Object],[object Object],“ Attachment and spreading of fibroblasts on an RGD peptide–modified injectable hyaluronan hydrogel.” Journal of Biomedical Materials Research. Part A. 63(2) (2004): 365-75.

Yea, fancy pants, but does it work? ,[object Object],[object Object],Fibroblast-seeded HA-DTPH–PEGDA hydrogel. “Attachment and spreading of fibroblasts on an RGD peptide–modified injectable hyaluronan hydrogel.” Journal of Biomedical Materials Research. Part A. 63(2) (2004): 365-75.

The Wrap ,[object Object],[object Object]

Watch Out For: ,[object Object],http://www.pharmacy.utah.edu/medchem/prestwich/aboutus.html

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