Bones pathology

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M Ridhwan Abd Razak

bones pathology

Health & Medicine

Component of bone
• Organic matrix
- Type I collagen: Osteoid + proteoglycan
- Type II collagen: cartillage
• Inorganic component
eg; Ca hydroxyapatite
• Cells
- Osteoprogenitor
- Osteoblast
- Osteocytes
-Osteoclast
• Tissue: Periosteum

Bone formation
• Production of Osteoid
• Mineralization of osteiod
• Remodelling by resoption & reformation
Osteoblast  (Production)
Osteoid  (Mineralization)
Woven bone  (Remodelling)
Lamellar bone.

Ossification
• Endochondrial Ossification –frm cartillage

• Membranous / Periosteal Ossification – frm
connective tissue

Bone Abnormalities
1. Cogenital
2. Metabolic bone Dx
3. Inflammation
4. Malignancies
5. Trauma/ Fractures

1. Congenital
• Achondroplasia
• Osteogenesis Imperfecta
• Osteopetrosis

2. Metabolic Bone Dx
• Osteoporosis
• Osteomalacia, Rickets
• Paget’s Dx (of bone!!)/ Oteitis deformans
• Renal Bone Dx/ Renal osteodystrophy
• Hyperparathyroidism

3. Inflammation
• Osteomyelitis
(osteon, meaning bone, myelo- meaning
marrow, and -itis meaning inflammation)

4. Malignancies
Bone tumors
Primary
Bone Forming
Tumors
Cartillage
Producing
Tumors
Others
Ewing’s Sarcoma
Myeloma
Solitary
plasmacytoma
Multiple
Myeloma
Osteoclastoma
(Giant cell
tumors)
Secondary

Malignancies
Bone Forming
Tumors
Benign
Osteoma
Osteoid
Osteoma
Ostoeblastoma
Malignant Osteosarcoma

Malignancies
Cartillage
Producing
Tumors
Benign
Osteochondroma
(En)chondroma
Malignant Chondrosarcoma

Malignancies
• Malignant  Primary (what it produce)
 Secondary (metastasis)
*most common bone tumours in children and
young adult Primary Bone Tumours
* most common bone tumours in older adult
Myeloma and Mets from other site (brest,
prostate, lung, kidney)

$5. Trauma/ Fractures • Comminuted • Displaced • Spiral • Complicated • Depressed • Stress fracture • Pathologic fracture (tumours, osteoporosis, osteomalacia, Paget’s, cogenital)$

Healing of bone
Haematoma Granulation
Procallus
formation (soft
tissue)
OssificationRemodelling

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CHONDROBLAST:Progenitor of chondrocytes Lines border between perichondrium and matrix Secretes type II collagen and other ECM components CHONDROCYTE: Mature cartilage cell Reside in a space called the lacuna Clear areas = Golgi and lipid droplets,RER PERICHONDRIUM:Dense irregularly arranged connective tissue Ensheaths the cartilage Houses the blood vessels that nourish chondrocytes CARTILAGE GROWTH:Appositional Increasing in WIDTH; chondroblasts deposit matrix on surface of pre-existing cartilage Interstitial Increasing in LENGTH; chondrocytes divide and secrete matrix from w/in lacunae

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