Definition of Rickets &Osteomalacia.
Etiology of Rickets & Osteomalacia
Rickets :
is defective mineralization of bones before epiphyseal closure (at growth plate) due to deficiency or impaired metabolism of vitamin D, phosphorus or calcium ,potentially leading to fractures and deformity.
Osteomalacia :
is a similar condition occurring in adults, generally due to impaired mineralization of the bone matrix. Due to a deficiency of vitamin D.
Etiology:
Vit D deficiency :
low intake plus inadequate sunlight exposure
malabsorption
Abnormal Vit D metabolism:
Impaired 25 OH Vitamin D production (Liver diseases)
Impaired 1,25 OH2 Vitamin D production (chronic renal failure or vitamin D-resistant rickets type I ).
Vitamin D receptor defects (vitaminD-resistant rickets type II)
Low calcium intake
Hypophosphatemia :
Low intake.
Inherited or acquired defects in renal tubular phosphate reabsorption.
Tumors that secrete phosphaturic substance.
Rickets and Osteomalacia are impaired memorization of the bone.
Causes of Rickets and Osteomalacia :
Vit D deficiency
Low calcium intake
Abnormal Vit D metabolism
Hypophosphatemia
3. Rickets :
is defective mineralization of bones before
epiphyseal closure (at growth plate) due to
deficiency or impaired metabolism of vitamin
D, phosphorus or calcium ,potentially leading
to fractures and deformity.
4. Osteomalacia :
is a similar condition occurring in adults,
generally due to impaired mineralization of
the bone matrix. Due to a deficiency of
vitamin D.
5. Vit D deficiency :
low intake plus inadequate sunlight exposure
malabsorption
Abnormal Vit D metabolism:
Impaired 25 OH Vitamin D production (Liver
diseases)
Impaired 1,25 OH2 Vitamin D production (chronic
renal failure or vitamin D-resistant rickets type I ).
Vitamin D receptor defects (vitaminD-resistant rickets
type II)
6. Low calcium intake
Hypophosphatemia :
Low intake.
Inherited or acquired defects in renal tubular
phosphate reabsorption.
Tumors that secrete phosphaturic substance.
7. Rickets and Osteomalacia are impaired
memorization of the bone.
Causes of Rickets and Osteomalacia :
Vit D deficiency
Low calcium intake
Abnormal Vit D metabolism
Hypophosphatemia
