DOPAMINE, EPINEPHRINE, METABOLISM AND DISTRIBUTION OF CATECHOLAMINES, Metabolic pathway of Catecholamines,

1. Dr. P.PARTHIBAN
PROFESSOR
VELLALAR COLLEGE OF PHARMACY

2.  Catecholamines are hormones made by your adrenal glands
which are located on top of your kidneys.
Eg. Include dopamine, norepinephrine and epinephrine
(called as adrenalline).
 Adrenal glands send catecholamines into blood when your
are physically or emotionally stressed.

3.  Catecholamine contain a catechol group and an
amino group.
 A catechol group is simply a benzene ring that has
hydroxyl groups on two adjacent carbons.
 Catecholamine biosynthesis takes place in
-Adrenergic & Dopaminergic neuron (CNS)
-Sympathetic neuron (ANS)
-Adrenal medulla
 Nor epinephrine and Epinephrine contain
catechol function (3,4-Dihydroxyphenol moiety)
in their structure, belong to a class known as
catecholamines.

5. The actions of adrenaline and Noradrenaline are
terminated by three processes.
 Re-uptake into the presynaptic neuron terminal.
 Diffusion from the junctional cleft and uptake at non-
neuronal sites
 Metabolic transformation of NE.

6. Metabolic pathway of Catecholamines

7. Metabolic pathway of Catecholamines