The document outlines India's biosafety guidelines for genetically engineered organisms (GEOs). It discusses the various committees that regulate rDNA research and implementation of biosafety guidelines in India. The Department of Biotechnology established the guidelines and oversees four committees - the Institutional Biosafety Committee, Review Committee on Genetic Manipulation, Genetic Engineering Approval Committee, and Recombinant DNA Advisory Committee - that implement and monitor the guidelines at institutional, review, approval, and advisory levels respectively.