The document summarizes two scientific studies. The first study found that silencing a gene called p57 that inhibits cell replication caused insulin-producing beta cells to reproduce, showing potential for diabetes treatment. The second study showed that a small molecule called BMH-21 disrupted cancer cell transcription pathways and prevented replication, showing promise as an anti-cancer therapy. Both studies explored new pathways for treating important diseases.

1. Silencing Inhibitor of Cell Replication Spurs
Insulin-Producing Beta Cells to Reproduce AND
Small Molecule Shows Promise as Anti-Cancer
Therapy
Biology Folding
Teacher: Lina Martínez
Jorge Luis Ferreira Morales
Medicine Student
III Semestrer
2014
UPB

4. •
Modifying the DNA of mutant and normal cells
is the new pathway which is leading all
investigations, and this offers the possibility to
predict the functions of a living cell and avoid
non wished facts.
•
New alternatives of treatment are being
discovered now, but the goal is to cure some
diseases knowing their weak points and in this
way, avoid deaths and extend this gorgeous
life.
•
Diabetes and Cancer are very important
diseases and these two news bring us some
findings about them.

5. Jan 16, 2014
Human pancreatic beta
Human pancreatic beta
cells are responsible of
cells are responsible of
producing an important
producing an important
hormone for life. Its called
hormone for life. Its called
Insulin
Insulin
Insulin function isisto allow
Insulin function to allow
the enter of glucose to
the enter of glucose to
some cells and therefore its
some cells and therefore its
responsible of maintaining
responsible of maintaining
normal blood glucose levels
normal blood glucose levels

6. SILENCING INHIBITOR OF CELL REPLICATION SPURS
INSULIN-PRODUCING BETA CELLS TO REPRODUCE
In this study, human pancreatic
beta cells were transplanted in a
mouse model, and they
replicated showing normal
functions.
Diabetes type I Ior IIIIimplicate
Diabetes type or implicate
destruction or less amount of
destruction or less amount of
pancreatic beta cells
pancreatic beta cells
So
Restoration of beta-cell
Restoration of beta-cell
mass can reverse or
mass can reverse or
ameliorate both forms of
ameliorate both forms of
diabetes.
diabetes.

7. SILENCING INHIBITOR OF CELL REPLICATION SPURS
INSULIN-PRODUCING BETA CELLS TO REPRODUCE

8. SILENCING INHIBITOR OF CELL REPLICATION SPURS
INSULIN-PRODUCING BETA CELLS TO REPRODUCE

9. In the future, suppressing genes
like p57 could lead the whole
world to better treatments.
This experiment shows that
investigations are being runned
out everywhere and researchers
are very foccussed on important
diseases with high prevalence in
the society.
Preventing or even cure a
pathology is an incredible
capacity of progress.

10. Jan 13 2014
Cancer is a malignant
Cancer is a malignant
disease characterized by
disease characterized by
mutant cells wihtout
mutant cells wihtout
control of cell’s growth.
control of cell’s growth.
There isisa gene (p53) that isis
There a gene (p53) that
a suppressor gene and
a suppressor gene and
prevents uncontrolled cell
prevents uncontrolled cell
growth but in cancer cells
growth but in cancer cells
this gene isismutated and
this gene mutated and
damaged.
damaged.

11. In this study, Johns Hopkins scientists
focused on the ability of BMH-21 to
sabotage the transcription pathway
RNA Polymerase pathway, preventing
replication and communication of
cancer cells.
Transcription pathways are the
Transcription pathways are the
means by which certain proteins
means by which certain proteins
that direct cell division are put
that direct cell division are put
into action by cells.
into action by cells.
Cancer without this
Cancer without this
transcription proccess can’t
transcription proccess can’t
function
function

14. Every intend of discovering a way to
fight against this tumors is a step
more to get to prevent and offer a
treatment for thousands of people
who become devastated when
they realized what they have is
cancer.
It’s sad to see how this illness takes a
lot of lives and finding a drug like
BMH-21 is really inspiring and
promising to the future of defeating
Cancer

19. •
Perelman School of Medicine at the University of
Pennsylvania. (2014, January 16). Silencing inhibitor of cell
replication spurs insulin-producing beta cells to reproduce.
ScienceDaily. Retrieved February 14, 2014 from
www.sciencedaily.com/releases/2014/01/140116162107.htm
•
Johns Hopkins Medicine. (2014, January 13). Small molecule
shows promise as anti-cancer therapy. ScienceDaily.
Retrieved February 14, 2014 from
www.sciencedaily.com/releases/2014/01/140113152629.htm