This document is a newsletter from the Department of Biochemistry at Adichunchanagiri Institute of Medical Sciences. It includes articles on various topics in biochemistry and its relationship to medicine. The editor provides a greeting and discusses how biochemistry illuminates disease processes and therapeutic interventions. Other articles discuss new information on microRNAs and their role in disease, advances in clinical laboratory science at the institute, selenocysteine and its importance in enzymes and cancer prevention, and fun puzzles related to biochemistry. The newsletter aims to share contemporary biochemistry information with readers.