The document discusses two scientific studies. The first study found that silencing a gene called p57 in human pancreatic beta cells caused the cells to replicate when transplanted into mice, showing promise for treating diabetes by restoring beta cell mass. The second study looked at a small molecule called BMH-21 that inhibits cancer cell replication by blocking a protein pathway, suggesting potential as an anti-cancer therapy. Both studies explored new approaches for treating important diseases like diabetes and cancer.

1. Silencing Inhibitor of Cell Replication Spurs
Insulin-Producing Beta Cells to Reproduce AND
Small Molecule Shows Promise as Anti-Cancer
Therapy
Biology Folding
Teacher: Lina Martínez
Jorge Luis Ferreira Morales
Medicine Student
III Semestrer
2014
UPB

4. •
Modifying the DNA of mutant and normal cells
is the new pathway which is leading all
investigations, and this offers the possibility to
predict the functions of a living cell and avoid
non wished facts.
•
New alternatives of treatment are being
discovered now, but the goal is to cure some
diseases knowing their weak points and in this
way, avoid deaths and extend this gorgeous
life.
•
Diabetes and Cancer are very important
diseases and these two news bring us some
findings about them.

5. Jan 16, 2014

6. SILENCING INHIBITOR OF CELL REPLICATION SPURS
INSULIN-PRODUCING BETA CELLS TO REPRODUCE
In this study, human pancreatic
beta cells were transplanted in a
mouse model, and they
replicated showing normal
functions.
Diabetes type I Ior IIIIimplicate
Diabetes type or implicate
destruction or less amount of
destruction or less amount of
pancreatic beta cells
pancreatic beta cells
So
Restoration of beta-cell
Restoration of beta-cell
mass can reverse or
mass can reverse or
ameliorate both forms of
ameliorate both forms of
diabetes.
diabetes.

7. SILENCING INHIBITOR OF CELL REPLICATION SPURS
INSULIN-PRODUCING BETA CELLS TO REPRODUCE

8. SILENCING INHIBITOR OF CELL REPLICATION SPURS
INSULIN-PRODUCING BETA CELLS TO REPRODUCE

9. In the future, suppressing genes
like p57 could lead the whole
world to better treatments.
This experiment shows that
investigations are being runned
out everywhere and researchers
are very foccussed on important
diseases with high prevalence in
the society.
Preventing or even cure a
pathology is an incredible
capacity of progress.

10. Jan 13 2014

11. In this study, Johns Hopkins scientists
focused on the ability of BMH-21 to
sabotage the transcription pathway
RNA Polymerase pathway, preventing
replication and communication of
cancer cells.
Transcription pathways are the
Transcription pathways are the
means by which certain proteins
means by which certain proteins
that direct cell division are put
that direct cell division are put
into action by cells.
into action by cells.
Cancer without this
Cancer without this
transcription proccess can’t
transcription proccess can’t
function
function

14. Every intend of discovering a way to
fight against this tumors is a step
more to get to prevent and offer a
treatment for thousands of people
who become devastated when
they realized what they have is
cancer.
It’s sad to see how this illness takes a
lot of lives and finding a drug like
BMH-21 is really inspiring and
promising to the future of defeating
Cancer

19. •
Perelman School of Medicine at the University of
Pennsylvania. (2014, January 16). Silencing inhibitor of cell
replication spurs insulin-producing beta cells to reproduce.
ScienceDaily. Retrieved February 14, 2014 from
www.sciencedaily.com/releases/2014/01/140116162107.htm
•
Johns Hopkins Medicine. (2014, January 13). Small molecule
shows promise as anti-cancer therapy. ScienceDaily.
Retrieved February 14, 2014 from
www.sciencedaily.com/releases/2014/01/140113152629.htm