NEW ROLE FOR THE JNK PROTEIN  AND  GENE ACTIVITY REGULATED BY HISTONE H1 Natalia Salazar Valderrama Medicine Student
FOLDING JULIO 26  DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN  AND  GENE ACTIVITY REGULATED BY HISTONE H1 MEDI...
FOLDING JULIO 26  DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN  AND  GENE ACTIVITY REGULATED BY HISTONE H1 MEDI...
INTRODUCTION <ul><li>In order to maintain the fidelity of the developing organism this process of cell division must be hi...
GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE  Medical News  Today  (J ul 06 ,  2010) JULIO 26  DE 2010 ...
GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE   Ribosomes are organelles composed of two different subun...
GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE   Histone H1 is very important in stabilizing chromatin hi...
GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE   Two each of the histones H2A, H2B, H3, and H4 come toget...
GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE   Phosphorylation is the addition of a phosphate group. No...
<ul><li>Each day we are discovering new activities and new functions that the proteins can do, and this going to help us t...
NEW ROLE FOR THE JNK PROTEIN:  LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE Science Daily (Jul...
NEW ROLE FOR THE JNK PROTEIN:  LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE The cell cycle is ...
NEW ROLE FOR THE JNK PROTEIN:  LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE The fidelity of ce...
The c-Jun N-terminal kinases (JNKs) are among the major subgroups of mitogen-activated protein kinases (MAP) that are indu...
<ul><li>Actually the medicine has to keep strengthen proteomic to continue advancing in this kind of findings and in this ...
MEDICAL UTILITY
<ul><li>This investigation is very important  because allow see the importance of knowledge about the different functions ...
<ul><li>Its important to know the different mechanism the phosphorylation on the proteins, because many of de drugs used d...
<ul><li>New role for the jnk protein: long known to help cells respond to stress, jnk also controls cell cycle. Science Da...
 
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Proteins & cell cycle ppt

  1. 1. NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 Natalia Salazar Valderrama Medicine Student
  2. 2. FOLDING JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ
  3. 3. FOLDING JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ
  4. 4. INTRODUCTION <ul><li>In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated </li></ul>The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer. JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer. INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer. INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  5. 5. GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE Medical News Today (J ul 06 , 2010) JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  6. 6. GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE Ribosomes are organelles composed of two different subunits, protein and RNA who are synthesized by the nucleolus. This organelles are responsible for assembling the proteins of the cell. JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  7. 7. GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE Histone H1 is very important in stabilizing chromatin higher-order structures, is called a &quot;linker&quot; histone because it binds the DNA between nucleosomes. Histones are proteins termed H1, H2A, H2B, H3, and H4 JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  8. 8. GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE Two each of the histones H2A, H2B, H3, and H4 come together to form a histone octamer, which binds and DNA. The H1 protein is a link. The nine histone proteins and 166 pairs of DNA form a nucleosome . H1 proteins interact with each other, causing the chromatin to form a spiral, with 6 nucleosomes, this is known as a solenoid. DNA is packaged with protein into chromosomes allowing a large amount of DNA to fit in a cell's nucleus. JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  9. 9. GENE ACTIVITY REGULATED BY HISTONE H1 THROUGHOUT THE CELL CYCLE Phosphorylation is the addition of a phosphate group. Normally we know that the H1 histone is only a clamp protein on nucleosome, but some investigators have finded that the H1 has been phosphorilared and has been associated with changes in gene activity around it. JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  10. 10. <ul><li>Each day we are discovering new activities and new functions that the proteins can do, and this going to help us to find new cures for the sickness, besides it remember us how important is the protein function in the human body and we may see that we know little about it. </li></ul>COMMENT
  11. 11. NEW ROLE FOR THE JNK PROTEIN: LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE Science Daily (Jul 16, 2010) JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  12. 12. NEW ROLE FOR THE JNK PROTEIN: LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE The cell cycle is an elaborated series of events whereby chromosomes and other cells’ components are duplicated and then distributed into two daughter cells. This process is fundamental to the development and function of all life. JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  13. 13. NEW ROLE FOR THE JNK PROTEIN: LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE The fidelity of cell reproduction also depends on regulatory mechanisms that ensure that the events of the cell cycle occur in the correct order. To ensure the correct order of events, the cell contains a complex regulatory network called the cell cycle control system, that controls their timing and coordination. The regular check points in the cell are between stage G1 and S, between stage S and G2 and between stage G2 and M. JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  14. 14. The c-Jun N-terminal kinases (JNKs) are among the major subgroups of mitogen-activated protein kinases (MAP) that are induced by diverse signals including growth factors, cytokines, tumor promoters, UV radiation, and hormones. The (MAP) kinases are enzymes that causes phosphorylation. NEW ROLE FOR THE JNK PROTEIN: LONG KNOWN TO HELP CELLS RESPOND TO STRESS, JNK ALSO CONTROLS CELL CYCLE JULIO 26 DE 2010 MEDELLIN, COLOMBIA NEW ROLE FOR THE JNK PROTEIN AND GENE ACTIVITY REGULATED BY HISTONE H1 MEDICAL UTILITY This investigation allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. BIBLIOGRAPHY http://www.sciencedaily.co/releases/2010/07/100714121741.htm Molecular Biology NATALIA SALAZAR VALDERRMA MEDICINE STUDENT 3rd SEMESTER TEACHER LINA MARIA MARTINEZ SANCHEZ INTRODUCTION During the cell division cell duplicates its contents and then divides into two cells. In order to maintain the fidelity of the developing organism this process of cell division must be highly ordered and tightly regulated. Actually we know some proteins who intervens in the process like P53, but thanks to different investigations we have known other proteins who could take part at the process or could be the same proteins with different functions. The important part is if during cell cycle the cell loss control will lead to abnormal development and is the cause of different diseases like cancer.
  15. 15. <ul><li>Actually the medicine has to keep strengthen proteomic to continue advancing in this kind of findings and in this way fight athwart the big health problems that suffer the humanity. </li></ul>COMMENT
  16. 16. MEDICAL UTILITY
  17. 17. <ul><li>This investigation is very important because allow see the importance of knowledge about the different functions of proteins in the human body, especially in cell cycle, besides this findings incite us to investigate more about proteins in cell cycle and orient it to prevent different diseases like cancer. </li></ul>MEDICAL UTILITY
  18. 18. <ul><li>Its important to know the different mechanism the phosphorylation on the proteins, because many of de drugs used daily to attack several diseases works phosphorylating diverse molecules and could cause damages that we don’t know, and could be responsible for the serious illness like cancer or leukemia to named some of them. </li></ul>MEDICAL UTILITY
  19. 19. <ul><li>New role for the jnk protein: long known to help cells respond to stress, jnk also controls cell cycle. Science Daily [Revista en internet] 2010 [Acceso 17 de Julio de 2010] Disponible en: http://www.sciencedaily.com/releases/2010/07/100714121741.htm </li></ul><ul><li>Gene activity regulated by histone h1 throughout the cell cycle. Medical new today [Revista en internet] 2010 [Acceso 22 de julo de 2010] Disponible en: http://www.medicalnewstoday.com/articles/193818.php </li></ul><ul><li>COOPER, Geoffrey. HAUSMAN, Robert. La celula. 4ta ed. Madrid: Marban, 2008. 818p. </li></ul>BIBLIOGRAPHY

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