"Epigenetics refers to genetic factors that change an organism’s appearance or biological functions without changing the actual DNA sequence. In other words, gene expression changes but the genes themselves don’t. Epigenetics adds an additional level of complexity to the genetic code." - Public Health Cafe
"Epigenetics refers to genetic factors that change an organism’s appearance or biological functions without changing the actual DNA sequence. In other words, gene expression changes but the genes themselves don’t. Epigenetics adds an additional level of complexity to the genetic code." - Public Health Cafe
The study of nucleic acids began with the discovery of DNA, progressed to the study of genes and small fragments, and has now exploded to the field of genomics. Genomics is the study of entire genomes, including the complete set of genes, their nucleotide sequence and organization, and their interactions within a species and with other species. The advances in genomics have been made possible by DNA sequencing technology. [Source: https://opentextbc.ca/biology/chapter/10-3-genomics-and-proteomics/]
Synopsis
Introduction
Some Facts
Types of SNPs
SNPs act as gene markers
Methods of Detection
Techniques to detect SNPs
Allelic Specific Cleavage
Differential Hybridization
Single Base Extension or minisequencing
Alternate Methods for Detecting SNPs
Mass Spectrometry
Microchips
SIGNIFICANCE OF SNPs
HAPLOTYPE
ADVANTAGES
Are SNP data available to the public?
Some important SNP database Resources
CONCLUSION
References
What is Genome,Genome mapping,types of Genome mapping,linkage or genetic mapping,Physical mapping,Somatic cell hybridization
Radiation hybridization ,Fish( =fluorescence in - situ hybridization),Types of probes for FISH,applications,Molecular markers,Rflp(= Restriction fragment length polymorphism),RFLPs may have the following Applications;Advantages of rflp,disAdvantages of rflp, Rapd(=Random amplification of polymorphic DNA),Process of rapd, Difference between rflp &rapd
Epigenetics is the study, in the field of genetics, of cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence. -Wikipedia
SNP (Single Nucleotide Polymorphic), SNP mapping, SNP profile, SNP types, SNP analysis by gel electropherosis and by mass spectrometry, SNP effects, single strand conformation polymorphism, SNP advantages and disadvantages and application of SNP profile in drug choice
The proteins are so much important, are versatile molecules because can realize diverses functions and we can use it like: enzymes: can catalysis chemical reactions
Hormones: the proteins can work with the plataletes to help to the blood coagulation
Transport of substances
Immunological factor: the antibodies produced with leukocyte
And the most important characteristic, they are molecular target so, we can use it to medical treatment, therapies to the cancer and another diseases . Also we can use the proteins presence and characteristic behavior for diagnosis of many sicknesses
1.Poor protein control key to Alzheimer's progression
New research investigating the pattern of protein build-up in Alzheimer's brains may open the door to a deeper understanding.
Previous research has identified that certain areas of the brain are more sensitive to the aggregation of proteins. The disease often begins in the entorhinal region (at the base of the brain) and spreads out to all of the neocortex (the largest part of the cerebral cortex)
How did it?
They analyzed approximately 500 samples of healthy brain taken from the Allen Brain Atlas In the healthy tissue, they observed a distinctive joint of genes important in the control of beta amyloid and tau protein. They contrasted with Alzheimer`s brains and discovered a identical pattern in advance of the sickness throughout the brain.
2. 2 Zika Virus Proteins Linked to Microcephaly ID'd
First study to examine Zika infection in human neural stem cells from second-trimester fetuses, researchers say.
USC researchers have tracked down two Zika proteins potentially responsible for thousands of microcephaly cases; taking one small step toward preventing Zika-infected mothers from birthing babies with abnormally small heads. Babies with microcephaly have abnormally small heads and brains. The Zika virus include 10 proteins, however only NS4B and NS4A are the responsible, in accordance with the study published in the journal Cell Stem Cell. These malicious proteins, researchers discovered, have two shared life goals: to handicap fetal brain formation and to mobilize their malevolent forces.
The study of nucleic acids began with the discovery of DNA, progressed to the study of genes and small fragments, and has now exploded to the field of genomics. Genomics is the study of entire genomes, including the complete set of genes, their nucleotide sequence and organization, and their interactions within a species and with other species. The advances in genomics have been made possible by DNA sequencing technology. [Source: https://opentextbc.ca/biology/chapter/10-3-genomics-and-proteomics/]
Synopsis
Introduction
Some Facts
Types of SNPs
SNPs act as gene markers
Methods of Detection
Techniques to detect SNPs
Allelic Specific Cleavage
Differential Hybridization
Single Base Extension or minisequencing
Alternate Methods for Detecting SNPs
Mass Spectrometry
Microchips
SIGNIFICANCE OF SNPs
HAPLOTYPE
ADVANTAGES
Are SNP data available to the public?
Some important SNP database Resources
CONCLUSION
References
What is Genome,Genome mapping,types of Genome mapping,linkage or genetic mapping,Physical mapping,Somatic cell hybridization
Radiation hybridization ,Fish( =fluorescence in - situ hybridization),Types of probes for FISH,applications,Molecular markers,Rflp(= Restriction fragment length polymorphism),RFLPs may have the following Applications;Advantages of rflp,disAdvantages of rflp, Rapd(=Random amplification of polymorphic DNA),Process of rapd, Difference between rflp &rapd
Epigenetics is the study, in the field of genetics, of cellular and physiological phenotypic trait variations that are caused by external or environmental factors that switch genes on and off and affect how cells read genes instead of being caused by changes in the DNA sequence. -Wikipedia
SNP (Single Nucleotide Polymorphic), SNP mapping, SNP profile, SNP types, SNP analysis by gel electropherosis and by mass spectrometry, SNP effects, single strand conformation polymorphism, SNP advantages and disadvantages and application of SNP profile in drug choice
The proteins are so much important, are versatile molecules because can realize diverses functions and we can use it like: enzymes: can catalysis chemical reactions
Hormones: the proteins can work with the plataletes to help to the blood coagulation
Transport of substances
Immunological factor: the antibodies produced with leukocyte
And the most important characteristic, they are molecular target so, we can use it to medical treatment, therapies to the cancer and another diseases . Also we can use the proteins presence and characteristic behavior for diagnosis of many sicknesses
1.Poor protein control key to Alzheimer's progression
New research investigating the pattern of protein build-up in Alzheimer's brains may open the door to a deeper understanding.
Previous research has identified that certain areas of the brain are more sensitive to the aggregation of proteins. The disease often begins in the entorhinal region (at the base of the brain) and spreads out to all of the neocortex (the largest part of the cerebral cortex)
How did it?
They analyzed approximately 500 samples of healthy brain taken from the Allen Brain Atlas In the healthy tissue, they observed a distinctive joint of genes important in the control of beta amyloid and tau protein. They contrasted with Alzheimer`s brains and discovered a identical pattern in advance of the sickness throughout the brain.
2. 2 Zika Virus Proteins Linked to Microcephaly ID'd
First study to examine Zika infection in human neural stem cells from second-trimester fetuses, researchers say.
USC researchers have tracked down two Zika proteins potentially responsible for thousands of microcephaly cases; taking one small step toward preventing Zika-infected mothers from birthing babies with abnormally small heads. Babies with microcephaly have abnormally small heads and brains. The Zika virus include 10 proteins, however only NS4B and NS4A are the responsible, in accordance with the study published in the journal Cell Stem Cell. These malicious proteins, researchers discovered, have two shared life goals: to handicap fetal brain formation and to mobilize their malevolent forces.
Discovery of new form of dystrophin protein could lead to therapy for some Duchenne muscular dystrophy patients
&
Genetics, lifestyle have a strong impact on biomarkers for inflammation, cancer
IRIDOLOGY RESEARCH BY GAEL RIVERZ N.D., IRIDOLOGISTSheldon Stein
A Presentation of the Work of Professor Serge Jurasunas in the Field of Cancer Detection through Iridology Profiling
(As Described his Last Important Book "Health and Disease Begin in the Colon, Featuring Prof. Serge Jurasunas’ Natural Medicine)
Here I show to you very interesting research news and medical utility. We can see the future of the epigenetics and molecular medicine.
Universidad Pontificia Bolivariana
Medicina School
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
Instructions for Submissions thorugh G- Classroom.pptxJheel Barad
This presentation provides a briefing on how to upload submissions and documents in Google Classroom. It was prepared as part of an orientation for new Sainik School in-service teacher trainees. As a training officer, my goal is to ensure that you are comfortable and proficient with this essential tool for managing assignments and fostering student engagement.
How to Create Map Views in the Odoo 17 ERPCeline George
The map views are useful for providing a geographical representation of data. They allow users to visualize and analyze the data in a more intuitive manner.
The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
For more information, visit-www.vavaclasses.com
Ethnobotany and Ethnopharmacology:
Ethnobotany in herbal drug evaluation,
Impact of Ethnobotany in traditional medicine,
New development in herbals,
Bio-prospecting tools for drug discovery,
Role of Ethnopharmacology in drug evaluation,
Reverse Pharmacology.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Unit 8 - Information and Communication Technology (Paper I).pdfThiyagu K
This slides describes the basic concepts of ICT, basics of Email, Emerging Technology and Digital Initiatives in Education. This presentations aligns with the UGC Paper I syllabus.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
We all have good and bad thoughts from time to time and situation to situation. We are bombarded daily with spiraling thoughts(both negative and positive) creating all-consuming feel , making us difficult to manage with associated suffering. Good thoughts are like our Mob Signal (Positive thought) amidst noise(negative thought) in the atmosphere. Negative thoughts like noise outweigh positive thoughts. These thoughts often create unwanted confusion, trouble, stress and frustration in our mind as well as chaos in our physical world. Negative thoughts are also known as “distorted thinking”.
2. Salome Rivera
Medicine Student
POLYGENIC
DISORDERS
BIBLIOGRAPHY
Medical University of Vienna. "Alzheimer's disease:
On the hunt for the biomarker signal for early
detection." ScienceDaily. ScienceDaily, 27 March
2017. From
www.sciencedaily.com/releases/2017/03/17032708
3239.htm
University of Manchester. "New role for immune
cells in preventing diabetes and hypertension."
ScienceDaily. ScienceDaily, 17 March 2017. From
www.sciencedaily.com/releases/2017/03/17031708
2510.htm
Martínez Sánchez, Lina Maria. Biología Molecular.
7 ed. Medellín: UPB. Fac.Medicina
MEDICAL
UTILITY
As main point, the fact of carrying
out studies on the genetic variants
responsible for the different
polygenic disorders allows
approaching a possible solution
that, unlike a treatment, gives way
to a preventive medicine.
Both studies give hope to the
patient and the medical staff, as it
is a clear example of progress.
3. INTRODUCTION
It´s a genetic disorder caused
by the action of more than one
gene, that is, the simultaneous
presence of several genes.
Likewise, they are going to be
influenced by the differents
environmental factors.
Are disorders that present a
high difficulty level of study
due to genetic variability of
each disease; for the same
reason, all of the methods used
for prevent genital
malformation have a difficult
application when we talk the
complex diseases and
polygenic.
ALZHEIMER´S
DISEASE AND OR
EARLY DETECTION
IMMUNE CELL FOR
THE DIABETES AND
HYPERTENSION
Alzheimer's
disease is
progressive
degenerative
diseases of the
brain,
What did they say?
There is a specific biomarker that
hasn't been found it. For this reason
the patient only start treatment once
the disease is clinically manifest
what is the objective?
Being able to diagnose the disease
long before having the clinical
manifestations and thus to avoid the
risk to develop it
Student’s opinion
Identifying the genes involved in the
development of this disease allows
patients to avoid the development of
each of them thanks to the
opportunity to find a cure.
Eosinophils are a variety of white blood
cells and one of the immune
system components responsible for
combating multicellular parasites and
certain infections in vertebrates
Student’s opinion
I consider that the
knowledge of the
functioning of some
cells as an effective
treatment for
diseases that are
difficult to prevent
gives the patients a
better quality of life.
what did they find?
They found that eosinophil levels were
severely decreased in PVATs in obese
individuals, so that the same tissue
function was affected, contributing to
type 2 diabetes and hypertension.
what is the objective?
PVAT from fat that lack eosinophils
could quickly be rescued by addition of
eosinophils,
4. IntroductionINTRODUCTION
It´s a genetic disorder caused
by the action of more than one
gene, that is, the simultaneous
presence of several genes.
Likewise, they are going to be
influenced by the differents
environmental factors.
Are disorders that present a
high difficulty level of study
due to genetic variability of
each disease; for the same
reason, all of the methods used
for prevent genital
malformation have a difficult
application when we talk the
complex diseases and
polygenic.
Are characterized by non-
Mendelian inheritance
The methods of the pairs affected in some
family members are used for detect the
genetic linkage by the interaction of
multiple genes, as long as the origin of the
chromosomes affected are identified
5. Alzheimer'sdisease:Onthehuntforthe
biomarkersignalforearlydetection
2017,March27
ALZHEIMER´S
DISEASE AND OR
EARLY DETECTION
Alzheimer's
disease is
progressive
degenerative
diseases of the
brain,
What did they say?
There is a specific biomarker that
hasn't been found it. For this reason
the patient only start treatment once
the disease is clinically manifest
what is the objective?
Being able to diagnose the disease
long before having the clinical
manifestations and thus to avoid the
risk to develop it
Student’s opinion
Identifying the genes involved in the
development of this disease allows
patients to avoid the development of
each of them thanks to the
opportunity to find a cure.
6. Alzheimer'sdisease:Onthehuntforthebiomarkersignalfor
earlydetection
Alzheimer's disease are
progressive degenerative of
the brain, which start up to
30 years before the onset of
symptoms
The disease is already lying
dormant in people who
appear completely healthy
from a clinical point of
view.
With the correct
measures, it is possible to
delay the clinical
symptoms of Alzheimer's
disease or to alleviate the
initial symptoms such as
forgetfulness
8. Alzheimer'sdisease:Onthehuntforthebiomarkersignalfor
earlydetection
In order to help Alzheimer's sufferers, the
EU project entitled "Memento," which is
being run by MedUni Vienna together
with the AIT (Austrian Institute of
Technology) and other international
partners, is concerned with developing
so-called electronic devices to help
sufferers in their everyday lives
GPS can be used to give verbal directions for finding
the way to the shops or back home again and there
are also similar devices for tracking people.
9. Student’s
opinion
I believe it is important to continue the
search for those specific biomarkers that
provide an approach to the possibility of
avoiding the development of Alzheimer's
and thus to help each patient with a
genetic predisposition
10. Newroleforimmunecellsinpreventing
diabetesandhypertension
2017,March17
IMMUNE CELL FOR
THE DIABETES AND
HYPERTENSION
Student’s opinion
I consider that the
knowledge of the
functioning of some
cells as an effective
treatment for
diseases that are
difficult to prevent
gives the patients a
better quality of life.
what did they find?
They found that eosinophil levels were
severely decreased in PVATs in obese
individuals, so that the same tissue
function was affected, contributing to
type 2 diabetes and hypertension.
what is the objective?
PVAT from fat that lack eosinophils
could quickly be rescued by addition of
eosinophils,
Eosinophils are a variety of white blood
cells and one of the immune
system components responsible for
combating multicellular parasites and
certain infections in vertebrates
11. Newroleforimmunecellsinpreventingdiabetesand
hypertension
Dr Sheena Cruickshank said: "This
type of immune cell is present in
many parts of the body and was once
thought to just act in parasitic
infections and allergies, but it's fast
becoming clear that they have a
significant effect on lots of aspects of
health and immunity."
12. Newroleforimmunecellsinpreventingdiabetesand
hypertension
Eosinophils are present in a layer of fat
tissue called the perivascular adipose
tissue (PVAT), which surrounds blood
vessels and helps to maintain normal
blood vessel function by reducing
artery contraction
It influenced the
release of nitric oxide
and a protein called
adiponectin, which
control healthy PVAT
function
14. Student’s
opinion
With this study we can observe the infinity of
knowledge that we still do not know about
many of the cells of our body, the infinity of
functions that each of them can have. Also the
fact of treating a disease with the same cells of
the body offers the possibility of treating these
diseases in a different way
15. Medicalutility
MEDICAL
UTILITY
As main point, the fact of carrying
out studies on the genetic variants
responsible for the different
polygenic disorders allows
approaching a possible solution
that, unlike a treatment, gives way
to a preventive medicine.
Both studies give hope to the
patient and the medical staff, as it
is a clear example of progress.
16. Medicalutility
With both studies provides the
possibility of reducing the morbidity
and mortality of each of these
diseases that affect a high
percentage of the population, as
well as better the quality of life and
decrease the costs of treatments
17. Medicalutility
Early diagnosis would be a great help to
combat Alzheimer's disease avoiding neuronal
deterioration, which is why they are looking
for an approximation to the specific
biomarker and a few years time, there could
potentially be a vaccination against this cause
of Alzheimer's.
18. Medicalutility
In addition to the use of body cells in the
treatment leading to an improvement, this
study shows that the eosinophils have a direct
role to play in processes in the body beyond
the immune system and this presents a new
area to investigate for a whole range of
illnesses
19. Bibliography • Medical University of Vienna. "Alzheimer's disease: On
the hunt for the biomarker signal for early detection."
ScienceDaily. ScienceDaily, 27 March 2017. From
www.sciencedaily.com/releases/2017/03/1703270832
39.htm
• University of Manchester. "New role for immune cells in
preventing diabetes and hypertension." ScienceDaily.
ScienceDaily, 17 March 2017. From
www.sciencedaily.com/releases/2017/03/17031708251
0.htm
• Martinez Sanchez, Lina Maria. Biología Molecular. 7
ed. Medellín: UPB. Fac.Medicina