1. Radiobiology is the study of the effects of ionizing radiation on biological tissues. DNA is the most sensitive structure affected, as it regulates cellular activity and contains genetic information.
2. Radiation can directly damage DNA molecules and other cellular components like RNA, enzymes, and proteins. However, most damage occurs indirectly when radiation interacts with water molecules within cells, producing ions and free radicals that then damage DNA.
3. The effects of radiation exposure depend on factors like radiation dose and the type of exposed cells. Somatic effects impact the exposed individual's health while genetic effects can impact future generations if reproductive cells are affected.
Effects of radiation
Signs and symptoms of radiation
Infected period of radiation
Dosage
Calculation of dosage
Units and SI units used
Diseases caused by radiation
Radioresistant
Effects of radiation
Signs and symptoms of radiation
Infected period of radiation
Dosage
Calculation of dosage
Units and SI units used
Diseases caused by radiation
Radioresistant
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RADIATION BIOLOGY- ORAL MEDICINE AND RADIOLOGYeducarenaac
A major theme for the radiobiology section is the use of radiation as a model agent to study cellular responses including genomic instability, cell cycle controls, DNA damage processing, oxidative stress, senescence, and apoptosis, as well as the signaling mechanisms mediating these and other stress responses.
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2 Case Reports of Gastric Ultrasound
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
2.
What is Radiobiology?
•The study of effect of ionizing radiation
on biological tissues
What is cell theory?
•Cell are basic functional unit of all plants
and animals
6.
DNA is the most sensitive structure to be affected by
radiations
It regulates cellular activity and contain genetic
information needed for cell replication.
Permanent changes alter the cell function and result
in cell death.
9.
In an X-RAY or some other type of radiation interact
with DNA molecules. Particular radiation because of
its mass cause more damage to DNA molecule.
Other particles like RNA enzymes and proteins can
also be affected by direct effect of radiations
DIRECT EFFECT OF
RADIATIONS
11.
Most of the damage to DNA molecules take place
through indirect effect. When X-rays enter a cell,
they most likely hit a water molecule because there
are large number of water molecules inside a cell.
The x-ray ionizes a water molecules. Ions, free
radicals are produced which in turn bond with DNA
molecule changing its structure. Since the x-ray
interacted with water molecule before the DNA Was
involved, this is called indirect effect
INDIRECT EFFECT
12.
A free radical is any atom or molecule that has a
single unpaired electron in an outer shell. While a
few free radicals such as melanin are not chemically
reactive, most biologically-relevant free radicals are
highly reactive. It is the primary mediatory of
indirect effect of radiation
FREE RADICAL
13.
Change or loss of base
Disruption of hydrogen
bonds between DNA strands
Breakage of one or both
DNA strands
What effects happen on
DNA due to radiations
14.
Ionization alters the structure of
cell but has no negative effect
Cells are damaged by ionization
but damage is repaired
Mutation can be occurred as well
cell damage is so extensive that
it can damage the cell
CELLULAR EFFECTS
15.
Greatest dose of radiation which is not expected to
cause detectable bodily injury to people at anytime
during their life
The amount of ionizing radiation a person may
exposed to supposedly without being harmed
The limits of ionizing radiation set for general public
by international commison on radiological
protection. For radiological workers this limit is
50msv
MAXIMUM
PERMISSIBLE DOSE
16.
The amount of ionizing radiation
that will kill 50% of population in a
specified time
MEDIAN LETHAL
DOSE
17.
Stochastic effects occur by chance and can be
compared to deterministic effects which result in a
direct effect.
The damaging effects may be induced when body is
exposed to any dose of radiations. Experimentally it
is not possible to establish a safe dose. It is therefore
assumed that there is no thresh-hold dose so that
every exposure does carry a stochastic effect
Stochastic effects
18.
Non-stochastic (deterministic effects) are somatic
effects that have a threshold that increase in severity
with the absorbed dose
Examples of non-stochastic effect include erythema,
loss of hair, cataract formation and decreased fertility
Compared to stochastic effects, deterministic effects
required a large dose to cause serious impairment of
health
DETERMINISTIC
EFFECTS
19.
Following the latent period, effects that are seen
within minutes, days, or weeks are termed short-
term effects. Short-term effects are associated with
large amounts of radiation absorbed in a short time
(e.g., exposure to a nuclear accident or the atomic
bomb).
Acute radiation syndrome (ARS) is a short-term
effect and includes nausea, vomiting, diarrhea, hair
loss, and hemorrhage.
Short-term effects are not applicable to dentistry
Short term effects
20.
Effects that appear after years, decades, or
generations are termed long-term effects.
Long-term effects are associated with small amounts
of radiation absorbed repeatedly over a long period.
Repeated low levels of radiation exposure are linked
to the induction of cancer, birth abnormalities, and
genetic defects
Long term effects
21.
All the cells in the body can be classified as either
somatic or genetic.
Somatic cells are all the cells in the body except the
reproductive cells.
The reproductive cells (e.g., ova, sperm) are termed
genetic cells.
Depending on the type of cell injured by radiation,
the biologic effects of radiation can be classified as
somatic or genetic.
SOMATIC AND
GENETIC EFFECTS
22.
Somatic effects are seen in the person who has been
irradiated. Radiation injuries that produce changes
in somatic cells produce poor health in the irradiated
individual.
Major somatic effects of radiation exposure include
the induction of cancer, leukemia, and cataracts.
These changes, however, are not transmitted to
future generations
SOMATIC EFFECTS
23.
The developing fetus is particularly sensitive to the effects of
radiation, especially during the period of organogenesis (2–9
weeks after conception).
Exposures in the range of 2 to 3 Gy during the first few days
after conception are thought to cause undetectable death of the
embryo.
The period of maximal sensitivity of the brain is 8 to 15 weeks
after conception.
The major problems are:
1.Congenital abnormalities or death associated with large doses
of radiation
2.Mental retardation associated with low doses of radiation.
As a result, the maximum permissible dose to the abdomen of a
woman who is pregnant is regulated by law.
EFFECT ON THE
UNBORN CHILD
26.
1. Skin: The reaction of the skin to radiation may be categorized as:
i. Early or acute signs:
• Increased susceptibility to chapping.
• Intolerance to surgical scrub.
• Blunting and leveling of finger ridges.
• Brittleness and ridging of finger nails.
ii. Late or chronic signs:
• Loosening of hair and epilation.
• Dryness and atrophy of skin, due to destruction of the sweat glands.
• Progressive pigmentation, telangiectasis and keratosis.
• Indolent type of ulcerations.
• Possibility of malignant changes in tissue.
RADIATION EFFECTS
ON CRITICAL ORGANS
27.
All these changes in the skin are due to radiation
trauma to:
1-The blood vessels.
2- Connective tissue.
3- Epithelium.
Early erythema may appear from a single dose of
about 450 rads.
With lower doses no erythema occurs
28.
13 mR for full mouth intraoral periapical radiographs.
A maximum dose of 200 R is required for any damage to
the marrow or blood forming organs.
Hence, the risk of bone marrow damage from dental X-
rays is small.
The primary somatic risk from dental radiography is
leukemia induction,especially in young individuals.
This is because at birth all bones contain only red bone
marrow. younger individuals are at a greater risk of
developing leukemia.
BONE MARROW
29.
THYROID
40 mR for full mouth intraoral periapical radiographs.
A dose of 10 R will produce thyroid cancer.
Gonadal – a single intraoral radiograph gives 100 to 900
mR to the face.
From this;
Male gonads receive 0.3 mR.
Female gonads receive 0.03 to 0.001 mR,
Eye – a series of full mouth intraoral periapical
radiographs, will give only a few mR.
Cataract of the lens is produced after 500 R of exposure