This document discusses Phytophthora soybean root and stem rot (PSRSR), a major soilborne disease of soybeans caused by the oomycete Phytophthora sojae. PSRSR can attack all parts of the soybean plant and causes symptoms like seed rot, damping off, root and stem rot, stunted growth, and yield losses up to 50%. The disease cycle of P. sojae is described. Resistance to PSRSR in soybeans can take the form of R-gene mediated resistance, partial resistance, or root resistance. Combining different resistance mechanisms, such as partial resistance and R-gene resistance, provides the best protection against this widespread and damaging disease.