Bioelectronic Medicine is a the new treatment procedure for diseases by using electrical pulses instead of the drug product. In this, there is a small implantation of the electrical devices, that will generate and develop periodical digital doses to the nerve bundles, which will produce the therapeutics effect for fighting against the diseases, and that will last for hours to full of the day that is dependent on the mechanism of the drug therapy. The implantable device like electronic brains and nerve-stimulating implants are not new devices because they have already been used in the treatment procedure of diseases. It is used for the treatment of the disorders like epilepsy, and parkinsonism and also for controlling the bladder. In this new class of medicine, whole of the treatment procedure is fully dependent on the accuracy, determination and the modulation of the electric signaling pattern in the whole of the nervous system. More targeted modulation can be achieved during the chronic disease, because of the functions controlled by the peripheral nervous are extensive during the time of chronic diseases (Bansal Niharika et al, 2019). A small implantable device is attached to the nerves of the individual, in the viscera of the peripheral nervous system. The device has an ability to decode and regulate the neural signaling pattern and provide the therapeutics effects to target at a specific organ (Bansal Niharika et al, 2019)

1. Bioelectronic
Medicine
Name: Pankaj Saha
Roll No: 18920322006
Dept: Pharmaceutics
M.Pharm 1st Semester, 1st Year

2. Table of Contents
Introduction
How it works?
Some Bioelectronic Medicines
Recent Advancements
Conclusion
References
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3. Introduction
Bioelectronic medicines defined as a new
class of treatment that depends on the
precision, detection and modulation of
electrical signaling patterns in the nervous
system.
Bioelectronic medicines are also
known as “electroceuticals” as they
used to treat the disease with
electrical impulses.
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4. Advantages of
Bioelectronic
Medicine
Bioelectronic Medicines allows patients and their
physicians to monitor the health parameters in real time.
Bioelectronic Medicines has zero or minimal side effects.
It will avoid or overcome the problems faced by
conventional dosage forms.
It could be customized for each patient to account for
severity of a disease for better patient compliance.
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5. How it Works?
Peripheral nerves send
signals from the brain to
the rest of the body
A small device attaches to
a nerve bundle of a
peripheral nerve
The device blocks or alters
signalling patterns passing
through individual nerve
fibre
These modified signals
travel to the target organs
and treating disease
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6. How it Works?
6
Fig: How Bioelectronic Medicine works

7. Artificial
Pacemaker
An artificial pacemaker is a type of device that is
surgically implanted to control and rectify an abnormal
heartbeat, with the help of electrical pulses.
The pacemaker has two main modes of operation:
demand mode and asynchronous mode.
The electrical impulses delivered by the pacemaker
cause the heart muscles to contract and pump blood,
restoring a normal heartbeat.
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8. Artificial Pacemaker
A pulse generator creates the electrical pulses.
Wires (also called leads) are implanted inside the veins
and carry the pulses to your heart.
When heartbeat is slower than normal, the electrodes
deliver electrical impulses to heart to make it beat
normally.
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Fig: How Artificial Pacemaker works

9. Artificial Pancreas
The artificial pancreas is a bioelectronic device for the
controlling of the blood glucose in diabetes patients.
It consists of three main components: a continuous
glucose monitor (CGM), an insulin pump, and a
control algorithm.
This device helps to monitor the glucose level
continuously.
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10. Artificial Pancreas
A CGM device measures the glucose levels in the interstitial
fluid every few minutes.
The control algorithm receives the glucose readings from
the CGM and uses them to determine the appropriate insulin
dose.
Based on the calculations made by the control algorithm,
the insulin pump delivers the necessary amount of insulin to
the patient.
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Fig: How Artificial Pancreas works

11. Visual Prosthesis
There are more than forty million blind individual form all
over the world are getting benefits from the discoveries of
the visual prosthesis.
A visual prosthesis typically consists of a retina implant, a
camera, a signal processor, a transmitter and a power
source.
The goal of a visual prosthesis is to improve the quality of
life for people with vision loss.
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12. Visual Prosthesis
Eyeglass video camera captures image
Image goes to computer worn on user's belt. It is digitized and sent
to an antenna
Antenna sends signal to a computer implant behind the ear
Computer sends image to retina implant
Retina sends image to brain through optical nerve
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Fig: How Visual Prosthesis works

13. Recent Advancements
Advancements on reflex mechanisms that can regulate the adaptive immunity
(Tracey et al, 2017).
Development of the devices that works on mechanisms for the reflex control of
the immunity, bleeding, breathing, blood pressure as well as the digestive system
(Bouton et al, 2019).
Development on the devices that are based on the using of the electricity for the
regulations of the biological process for the treatment of the diseases as well as
for the restoration of the lost functionality (Pavlov et al, 2019).
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14. Conclusion
With the vision of revolutionizing the system of medicines, Bioelectronic Medicine hold the
promise in achieving the therapeutic intervention by modulating the signaling patterns of
the nerve impulses. These medicines include such devices which are implanted and record
the neural activity.
However, these therapies still require a multidisciplinary approach to produce less
invasive techniques. In order to achieve this, development of nanotechnology materials and
new methodologies will greatly contribute to this field.
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15. References
1. Datta T, Zanos T, Chang EH, Olofsson PS, Bickel S, Bouton C, et al. The Fourth
Bioelectronic Medicine Summit “Technology Targeting Molecular Mechanisms”: current
progress, challenges, and charting the future. Bioelectronic Medicine. 2021;7(1):7
2. Patel DA, Choudhary S. Bioelectronic Medicines: Innovation In Disease Treatment.
International Journal of Pharmaceutical Sciences and Research, 2020;11(9): 4229-4237.
3. Sabu F, Jiju V, Abraham E. Bioelectronic Medicine – A Review. World Journal of
Pharmaceutical and Life Sciences, 2020;9(6):1035–59.
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16. References
1. Tripathy SK. Bioelectronic Medicine: A Newer Treatment Procedure For The Current
Generation Of People. World Journal of Pharmaceutical Research, 2020;9(6):1035–59.
4. https://ichef.bbci.co.uk/news/976/cpsprodpb/17E34/production/_128244879_artificial_pa
ncreas_3x640-nc.png (Accessed on 27/01/2023)
5. https://www.nhlbi.nih.gov/sites/default/files/inline-images/images_279.jpg (Accessed on
27/01/2023)
6. https://www.mypharmaguide.com/wp-content/uploads/2023/01/Picture1.jpg (Accessed
on 27/01/2023) 16