The document discusses the Beckmann rearrangement reaction, which is the acid-catalyzed conversion of ketoximes to amides. This reaction can occur in both cyclic and acyclic compounds using various reagents like concentrated sulfuric acid. Cyclic oximes yield lactams, while acyclic oximes yield amides. The Beckmann rearrangement has applications in drug production, such as the synthesis of paracetamol, as well as polymer synthesis like the production of nylon 12.

1. BECKMANN
REARRANGEMENT
• MADISH NIAZ

2. APPLICATIONS OF
BECKMANN
REARRANGEMENT
REACTIONS:
The acid-catalysed conversion of
ketoximes to amides is known as
the Beckmann rearrangement
This rearrangement is occurs in
both cyclic and acyclic
compounds .
Aldoximes are less reactive.

3. COMMON
REAGENTS:
Conc.H2SO4
HCl
PCl5
PCl3
SOCl2
ZnO
SiO2
P P A (Poly phosphoric acid)

4. APPLICATIONS:
•Cyclic oximes yield
lactams
•Acyclic oximes yield
amides
•In drugs production
•In polymer synthesis

5. RXN USING REAGENT Conc.H2SO4
Acetophenone oxime
Acetaniline
tautomerization

6. KETOXIME TO AMIDE USING Conc.H2SO4
thiophencaboxketone
tautomerization

7. KETOXIME TO AMIDE USING PCl5 :
thiophencaboxketone
tautomerization

8. KETOXIME TOAMIDE USING HSO3 CH3

9. RXNUSINGREAGENTPPA(POLYPHOSPHORIC ACID):

10. DRUGSYNTHESIS:
• An alternative industrial synthesis method for Paracetamol.
7
Paracetamol
PHENOL
(acetic anhydride)
Ketone Ketoxime
Hydroxylamine

11. OTHERDRUGS:
11
•TheBeckmann
rearrangement isalsousedin
the synthesis of
•DHEA
•Benazepril
•Etazepineetc.

12. POLYMERSYNTHESIS:
12
cyanuric chloride
cyclododecanone
Nylon12

13. POLYMER SYNTHESIS:
13
NYLON 12

14. THANK U