My Thesis Topic was "Motor Imagery Signal Classification using EEG and ECoG signal for Brain Computer Interface." I have done my undergraduate thesis on the study, comparison and development of newer algorithms and feature sets related to two class classification problem in Motor Imagery Signal Classification using EEG and ECoG signal for Brain Computer Interface under the supervision of Dr. Mohammad Imamul Hassan Bhuiyan, Professor, Department of Electrical and Electronic Engineering, Bangladesh University of Engineering and Technology.
EEG Based BCI Applications with Deep LearningRiddhi Jain
Summarised a Survey Paper describing EEG Based BCI Applications and Sensing Technologies and their Computational Intelligence Approach published on Jan 28, 2020
Classification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELMIJTET Journal
Abstract—This paper proposes the classification of EEG signal for epilepsy diagnosis. Epilepsy is a neurological disorder which occurs due to synchronous neuronal activity in brain. Empirical Mode Decomposition (EMD), Extreme Learning Machine (ELM) are the techniquedelivered in the proposed method.Input EEG signal, which is available in online as Bonn Database is decomposed into five Intrinsic Mode Functions (IMFs) using EMD.Higher Order Statistical moments such as Variance, Skewness and Kurtosis are drawn out as features from the decomposed signals. Extreme Learning Machine is used as a classifier to classify the EEG signals with the taken features, under various categories that include healthy and ictal, interictal and ictal, Non seizure and seizure, healthy, interictal and ictal. The proposed method gives 100%accuracy, 100%sensitivity in discriminating interictal and ictal, non seizure and seizure, healthy and ictal, healthy, interictal and ictal, 100% specificity in classifying healthy and ictal, interictal and ictal and 100% and 99%accuracy in case of discriminating interictal and ictal, non seizure and seizure.
Variants of Support Vector
Machines (SVM) were employed for classification and also
compared the results with Multi-layered Perceptron (MLP).
Empirical results show that both SVM and MLP were suitable
for such motor imagery classifications with the accuracies 85%
and 85.71% respectively. Among all employed feature extraction
techniques wavelet-based methods specifically the energy-
entropy feature set gave promising results for both the classifiers.
Combining Optical Brain Imaging and Physiological Signals to Study Cognitive ...InsideScientific
In this exclusive webinar sponsored by BIOPAC Systems and fNIR Devices, Dr. Hasan Ayaz, Dr. Kurtulus Izzetoglu and Frazer Findlay present new research capabilities enabled through the integration of optical brain imaging technology and physiological recording systems.
Key topics covered during this webinar include physiological and physical principles of optical brain imaging, theory of operation, hardware and software integration, essential fNIR signal processing (demonstrated using fnirSoft analysis software), common field applications of fNIR imaging, why and how researchers can measure physiological data such as EDA, HR and ECG and acquistion procedures for co-registration of fNIR data and physiological monitoring signals using AcqKnowledge data acquisition and analysis software.
fNIRS and Brain Computer Interface for CommunicationInsideScientific
LIVE WEBINAR: June 8, 2017
Dr. Ujwal Chaudhary and Dr. Bettina Sorger present groundbreaking research in the field of fNIRS-based BCI for communication with healthy subjects and patients in completely locked-in states.
Neural activity is accompanied by a hemodynamic (vascular) responses that is sensitive to a host of features of coordinated brain function. Relating these measures to the seemingly endless breadth of human behavior is a principal aim of many scientific investigations. Fortunately, learning, language acquisition, sensory and motor functions, emotion, social interactions, and the influence of a host of disease processes can all be explored from measures of the functional near-infrared spectroscopy (fNIRS) signal. Wearable fNIRS technology exists that is portable, safe and easy to use, resistant to motion artifacts and can be employed in a subjects natural environment.
A promising application for fNIRS is the design of brain-computer interfaces (BCIs) for communication with completely locked-in patients. In the so called ‘locked-in’ state, fully conscious and awake patients are unable to communicate naturally due to severe motor paralysis. These patients are, however, able to modulate their brain activity which can be decoded and understood by exploring the fNIRS signal.
In this exclusive webinar sponsored by NIRx Medical Technologies, experts present the basic principles of fNIRS and BCI, technical setup and guidelines for running a successful fNIRS study and a comparison of fNIRS with other functional neuroimaging methods. Presenters highlight groundbreaking research in the field of fNIRS-based BCI for communication with healthy subjects and patients in a completely locked-in state. Specifically, Dr. Ujwal Chaudhary (University of Tübingen) shares results of his research with healthy participants and patients with locked-in syndrome due to amyotrophic lateral sclerosis (ALS). Dr. Bettina Sorger (Maastricht University) presents data from a recent study demonstrating the feasibility of a multiple-choice fNIRS-based communication BCI using differently-timed motor imagery as an information-encoding strategy.
This document will examine issues pertaining to feature extraction, classification and prediction. It will
consider the application of these techniques to unlabelled Electroencephalogram (E.E.G.) data in an
attempt to discriminate between left and right hand imagery movements
My Thesis Topic was "Motor Imagery Signal Classification using EEG and ECoG signal for Brain Computer Interface." I have done my undergraduate thesis on the study, comparison and development of newer algorithms and feature sets related to two class classification problem in Motor Imagery Signal Classification using EEG and ECoG signal for Brain Computer Interface under the supervision of Dr. Mohammad Imamul Hassan Bhuiyan, Professor, Department of Electrical and Electronic Engineering, Bangladesh University of Engineering and Technology.
EEG Based BCI Applications with Deep LearningRiddhi Jain
Summarised a Survey Paper describing EEG Based BCI Applications and Sensing Technologies and their Computational Intelligence Approach published on Jan 28, 2020
Classification of EEG Signal for Epileptic Seizure DetectionusingEMD and ELMIJTET Journal
Abstract—This paper proposes the classification of EEG signal for epilepsy diagnosis. Epilepsy is a neurological disorder which occurs due to synchronous neuronal activity in brain. Empirical Mode Decomposition (EMD), Extreme Learning Machine (ELM) are the techniquedelivered in the proposed method.Input EEG signal, which is available in online as Bonn Database is decomposed into five Intrinsic Mode Functions (IMFs) using EMD.Higher Order Statistical moments such as Variance, Skewness and Kurtosis are drawn out as features from the decomposed signals. Extreme Learning Machine is used as a classifier to classify the EEG signals with the taken features, under various categories that include healthy and ictal, interictal and ictal, Non seizure and seizure, healthy, interictal and ictal. The proposed method gives 100%accuracy, 100%sensitivity in discriminating interictal and ictal, non seizure and seizure, healthy and ictal, healthy, interictal and ictal, 100% specificity in classifying healthy and ictal, interictal and ictal and 100% and 99%accuracy in case of discriminating interictal and ictal, non seizure and seizure.
Variants of Support Vector
Machines (SVM) were employed for classification and also
compared the results with Multi-layered Perceptron (MLP).
Empirical results show that both SVM and MLP were suitable
for such motor imagery classifications with the accuracies 85%
and 85.71% respectively. Among all employed feature extraction
techniques wavelet-based methods specifically the energy-
entropy feature set gave promising results for both the classifiers.
Combining Optical Brain Imaging and Physiological Signals to Study Cognitive ...InsideScientific
In this exclusive webinar sponsored by BIOPAC Systems and fNIR Devices, Dr. Hasan Ayaz, Dr. Kurtulus Izzetoglu and Frazer Findlay present new research capabilities enabled through the integration of optical brain imaging technology and physiological recording systems.
Key topics covered during this webinar include physiological and physical principles of optical brain imaging, theory of operation, hardware and software integration, essential fNIR signal processing (demonstrated using fnirSoft analysis software), common field applications of fNIR imaging, why and how researchers can measure physiological data such as EDA, HR and ECG and acquistion procedures for co-registration of fNIR data and physiological monitoring signals using AcqKnowledge data acquisition and analysis software.
fNIRS and Brain Computer Interface for CommunicationInsideScientific
LIVE WEBINAR: June 8, 2017
Dr. Ujwal Chaudhary and Dr. Bettina Sorger present groundbreaking research in the field of fNIRS-based BCI for communication with healthy subjects and patients in completely locked-in states.
Neural activity is accompanied by a hemodynamic (vascular) responses that is sensitive to a host of features of coordinated brain function. Relating these measures to the seemingly endless breadth of human behavior is a principal aim of many scientific investigations. Fortunately, learning, language acquisition, sensory and motor functions, emotion, social interactions, and the influence of a host of disease processes can all be explored from measures of the functional near-infrared spectroscopy (fNIRS) signal. Wearable fNIRS technology exists that is portable, safe and easy to use, resistant to motion artifacts and can be employed in a subjects natural environment.
A promising application for fNIRS is the design of brain-computer interfaces (BCIs) for communication with completely locked-in patients. In the so called ‘locked-in’ state, fully conscious and awake patients are unable to communicate naturally due to severe motor paralysis. These patients are, however, able to modulate their brain activity which can be decoded and understood by exploring the fNIRS signal.
In this exclusive webinar sponsored by NIRx Medical Technologies, experts present the basic principles of fNIRS and BCI, technical setup and guidelines for running a successful fNIRS study and a comparison of fNIRS with other functional neuroimaging methods. Presenters highlight groundbreaking research in the field of fNIRS-based BCI for communication with healthy subjects and patients in a completely locked-in state. Specifically, Dr. Ujwal Chaudhary (University of Tübingen) shares results of his research with healthy participants and patients with locked-in syndrome due to amyotrophic lateral sclerosis (ALS). Dr. Bettina Sorger (Maastricht University) presents data from a recent study demonstrating the feasibility of a multiple-choice fNIRS-based communication BCI using differently-timed motor imagery as an information-encoding strategy.
This document will examine issues pertaining to feature extraction, classification and prediction. It will
consider the application of these techniques to unlabelled Electroencephalogram (E.E.G.) data in an
attempt to discriminate between left and right hand imagery movements
Aim of a brain-computer interface (BCI) is to provide a communication channel for paralyzed patients to interact with the outer world. I will start with the motivation behind brain-computer interfaces followed by description of a general BCI. I will then describe various kinds of BCI experiments and methods.
From the Un-Distinguished Lecture Series (http://ws.cs.ubc.ca/~udls/). The talk was given Jun. 8, 2007.
Poster Presentation on "Artifact Reduction from Scalp EEG for Epilepsy Seizur...Md Kafiul Islam
This research presents a method to reduce artifacts from scalp EEG recordings to facilitate seizure diagnosis/detection for epilepsy patients. The proposed method is primarily based on stationary wavelet transform and takes the spectral band of seizure activities (i.e. 0.5 - 30 Hz) into account to separate artifacts from seizures. It requires a reference seizure epoch of N-sec which can either be generated from a patient-specific
seizure database (if available) or can be simulated by a simple mathematical model of seizure. The purpose of the algorithm is to reduce as much artifacts as possible without distorting the desired seizure events to be detected/diagnosed. Different artifact templates have been simulated to mimic the most commonly appeared artifacts in real EEG recordings. The algorithm is applied on three sets of synthesized data:
fully simulated, semi-simulated and real data to evaluate both the artifact removal performance and seizure detection performance. The EEG features responsible for detection of seizures from non-seizure epochs have been found to be easily distinguishable after artifacts are removed and consequently reduces the false alarms in seizure detection. Results from an extensive experiment with these datasets prove the efficacy of
the proposed algorithm and hence this algorithm (with some modifications) is expected to be a future candidate for artifact removal not only in epilepsy diagnosis applications but also in other applications (e.g. BCI or other neuroscience studies).
Performance Comparison of Known ICA Algorithms to a Wavelet-ICA MergerCSCJournals
Electroencephalogram (EEG) is useful for biological research and clinical diagnosis. These signals are however contaminated with artifacts which must be removed to have pure EEG signals. These artifacts can be removed by using Independent Component Analysis (ICA). In this paper we studied the performance of three ICA algorithms (FastICA, JADE, and Radical) as well as our newly developed ICA technique which utilizes wavelet transform. Comparing these ICA algorithms, it is observed that our new technique performs as well as these algorithms at denoising EEG signals.
Feature Extraction Techniques and Classification Algorithms for EEG Signals t...Editor IJCATR
EEG (Electroencephalogram) signal is a neuro signal which is generated due the different electrical activities in the brain.
Different types of electrical activities correspond to different states of the brain. Every physical activity of a person is due to some
activity in the brain which in turn generates an electrical signal. These signals can be captured and processed to get the useful information
that can be used in early detection of some mental diseases. This paper focus on the usefulness of EGG signal in detecting the human
stress levels. It also includes the comparison of various preprocessing algorithms ( DCT and DWT.) and various classification algorithms
(LDA, Naive Bayes and ANN.). The paper proposes a system which will process the EEG signal and by applying the combination of
classifiers, will detect the human stress levels.
- To study the behavior and properties of bio-electric signals.
- Develop a system to identify and recognize patterns of signals on a portable computer.
With the introduction of Blue Brain technology, which is a reverse engineering, we can overcome all the brain disorders and diseases. Blue Brain is the name of the world’s first virtual brain which makes a machine, function as a human brain. Even after the death of the person the complete functional attribute of a human brain can be stored in that and can be used for further development.
SF Big Analytics20170706: What the brain tells us about the future of streami...Chester Chen
Much of the world’s data is becoming streaming, time-series data. It becomes increasingly important to analyze streaming data in real-time. Hierarchal Temporal Memory (HTM) is a detailed computational theory of the neocortex. At the core of HTM are time-based learning algorithms that store and recall spatial and temporal patterns. HTM is well suited to a wide variety of problems; particularly those involve streaming data and time-based patterns. The current HTM systems are able to learn the structure of streaming data, make predictions and detect anomalies. It is distinguished from other techniques in its ability to learn continuously in a fully unsupervised manner. HTM has been tested and implemented in software, all of which is developed with best practices and is suitable for deploying in commercial applications. The core learning algorithms are fully documented and available in an open source project called NuPIC. HTM not only advances our understanding of how the brain may solve the sequence learning problem but is also applicable to real-world sequence learning problems from continuous data streams.
Speaker
Yuwei Cui a Research Staff Member at Numenta, a company focused on Machine Intelligence. His professional interests are in the areas of Artificial Intelligence, Computational Neuroscience, Computer Vision and Machine Learning. He became interested in AI while studying physics in the University of Science and Technology of China
He later went on to get a PhD in computational neuroscience, specializing in understanding how our visual system process sensory inputs and contribute to perceptions, from the University of Maryland at College Park. He became fascinated by the brain and reverse engineering its underlying computational principles. He has published numerous peer-reviewed scientific articles in Neuroscience and AI.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
⭐⭐⭐⭐⭐ SSVEP-EEG Signal Classification based on Emotiv EPOC BCI and Raspberry PiVictor Asanza
This work presents the experimental design for recording Electroencephalography (EEG) signals in 20 test subjects submitted to Steady-state visually evoked potential (SSVEP). The stimuli were performed with frequencies of 7, 9, 11 and 13 Hz. Furthermore, the implementation of a classification system based on SSVEP-EEG signals from the occipital region of the brain obtained with the Emotiv EPOC device is presented. These data were used to train algorithms based on artificial intelligence in a Raspberry Pi 4 Model B. Finally, this work demonstrates the possibility of classifying with times of up to 1.8 ms in embedded systems with low computational capacity.
⭐ For more information visit our blog:
https://vasanza.blogspot.com/
Development of wearable object detection system & blind stick for visuall...Arkadev Kundu
It is a wearable device. It has a camera, and it detects all living and non living object. This module detects moving object also. It is made with raspberry pi 3, and a camera. One headphone connect with raspberry pi. When this module detects items, it gave a sound output through headphone. Hence the blind man know that item, which is in-front of him or her. We made it in very low budget, and it is very helpful for visually challenged people. And the Blind stick help him to detect obstacles.
Aim of a brain-computer interface (BCI) is to provide a communication channel for paralyzed patients to interact with the outer world. I will start with the motivation behind brain-computer interfaces followed by description of a general BCI. I will then describe various kinds of BCI experiments and methods.
From the Un-Distinguished Lecture Series (http://ws.cs.ubc.ca/~udls/). The talk was given Jun. 8, 2007.
Poster Presentation on "Artifact Reduction from Scalp EEG for Epilepsy Seizur...Md Kafiul Islam
This research presents a method to reduce artifacts from scalp EEG recordings to facilitate seizure diagnosis/detection for epilepsy patients. The proposed method is primarily based on stationary wavelet transform and takes the spectral band of seizure activities (i.e. 0.5 - 30 Hz) into account to separate artifacts from seizures. It requires a reference seizure epoch of N-sec which can either be generated from a patient-specific
seizure database (if available) or can be simulated by a simple mathematical model of seizure. The purpose of the algorithm is to reduce as much artifacts as possible without distorting the desired seizure events to be detected/diagnosed. Different artifact templates have been simulated to mimic the most commonly appeared artifacts in real EEG recordings. The algorithm is applied on three sets of synthesized data:
fully simulated, semi-simulated and real data to evaluate both the artifact removal performance and seizure detection performance. The EEG features responsible for detection of seizures from non-seizure epochs have been found to be easily distinguishable after artifacts are removed and consequently reduces the false alarms in seizure detection. Results from an extensive experiment with these datasets prove the efficacy of
the proposed algorithm and hence this algorithm (with some modifications) is expected to be a future candidate for artifact removal not only in epilepsy diagnosis applications but also in other applications (e.g. BCI or other neuroscience studies).
Performance Comparison of Known ICA Algorithms to a Wavelet-ICA MergerCSCJournals
Electroencephalogram (EEG) is useful for biological research and clinical diagnosis. These signals are however contaminated with artifacts which must be removed to have pure EEG signals. These artifacts can be removed by using Independent Component Analysis (ICA). In this paper we studied the performance of three ICA algorithms (FastICA, JADE, and Radical) as well as our newly developed ICA technique which utilizes wavelet transform. Comparing these ICA algorithms, it is observed that our new technique performs as well as these algorithms at denoising EEG signals.
Feature Extraction Techniques and Classification Algorithms for EEG Signals t...Editor IJCATR
EEG (Electroencephalogram) signal is a neuro signal which is generated due the different electrical activities in the brain.
Different types of electrical activities correspond to different states of the brain. Every physical activity of a person is due to some
activity in the brain which in turn generates an electrical signal. These signals can be captured and processed to get the useful information
that can be used in early detection of some mental diseases. This paper focus on the usefulness of EGG signal in detecting the human
stress levels. It also includes the comparison of various preprocessing algorithms ( DCT and DWT.) and various classification algorithms
(LDA, Naive Bayes and ANN.). The paper proposes a system which will process the EEG signal and by applying the combination of
classifiers, will detect the human stress levels.
- To study the behavior and properties of bio-electric signals.
- Develop a system to identify and recognize patterns of signals on a portable computer.
With the introduction of Blue Brain technology, which is a reverse engineering, we can overcome all the brain disorders and diseases. Blue Brain is the name of the world’s first virtual brain which makes a machine, function as a human brain. Even after the death of the person the complete functional attribute of a human brain can be stored in that and can be used for further development.
SF Big Analytics20170706: What the brain tells us about the future of streami...Chester Chen
Much of the world’s data is becoming streaming, time-series data. It becomes increasingly important to analyze streaming data in real-time. Hierarchal Temporal Memory (HTM) is a detailed computational theory of the neocortex. At the core of HTM are time-based learning algorithms that store and recall spatial and temporal patterns. HTM is well suited to a wide variety of problems; particularly those involve streaming data and time-based patterns. The current HTM systems are able to learn the structure of streaming data, make predictions and detect anomalies. It is distinguished from other techniques in its ability to learn continuously in a fully unsupervised manner. HTM has been tested and implemented in software, all of which is developed with best practices and is suitable for deploying in commercial applications. The core learning algorithms are fully documented and available in an open source project called NuPIC. HTM not only advances our understanding of how the brain may solve the sequence learning problem but is also applicable to real-world sequence learning problems from continuous data streams.
Speaker
Yuwei Cui a Research Staff Member at Numenta, a company focused on Machine Intelligence. His professional interests are in the areas of Artificial Intelligence, Computational Neuroscience, Computer Vision and Machine Learning. He became interested in AI while studying physics in the University of Science and Technology of China
He later went on to get a PhD in computational neuroscience, specializing in understanding how our visual system process sensory inputs and contribute to perceptions, from the University of Maryland at College Park. He became fascinated by the brain and reverse engineering its underlying computational principles. He has published numerous peer-reviewed scientific articles in Neuroscience and AI.
International Journal of Engineering Research and Applications (IJERA) is an open access online peer reviewed international journal that publishes research and review articles in the fields of Computer Science, Neural Networks, Electrical Engineering, Software Engineering, Information Technology, Mechanical Engineering, Chemical Engineering, Plastic Engineering, Food Technology, Textile Engineering, Nano Technology & science, Power Electronics, Electronics & Communication Engineering, Computational mathematics, Image processing, Civil Engineering, Structural Engineering, Environmental Engineering, VLSI Testing & Low Power VLSI Design etc.
⭐⭐⭐⭐⭐ SSVEP-EEG Signal Classification based on Emotiv EPOC BCI and Raspberry PiVictor Asanza
This work presents the experimental design for recording Electroencephalography (EEG) signals in 20 test subjects submitted to Steady-state visually evoked potential (SSVEP). The stimuli were performed with frequencies of 7, 9, 11 and 13 Hz. Furthermore, the implementation of a classification system based on SSVEP-EEG signals from the occipital region of the brain obtained with the Emotiv EPOC device is presented. These data were used to train algorithms based on artificial intelligence in a Raspberry Pi 4 Model B. Finally, this work demonstrates the possibility of classifying with times of up to 1.8 ms in embedded systems with low computational capacity.
⭐ For more information visit our blog:
https://vasanza.blogspot.com/
Development of wearable object detection system & blind stick for visuall...Arkadev Kundu
It is a wearable device. It has a camera, and it detects all living and non living object. This module detects moving object also. It is made with raspberry pi 3, and a camera. One headphone connect with raspberry pi. When this module detects items, it gave a sound output through headphone. Hence the blind man know that item, which is in-front of him or her. We made it in very low budget, and it is very helpful for visually challenged people. And the Blind stick help him to detect obstacles.
This presentation shows the impact of GPU computing on cognitive robotics by showing a series of novel experiments in the area of action and language acquisition in humanoid robots and computer vision. Cognitive robotics is concerned with endowing robots with high-level cognitive capabilities to enable the achievement of complex goals in complex environments. Reaching the ultimate goal of developing cognitive robots will require tremendous amount of computational power, which was until recently provided mostly by standard CPU processors. However, CPU cores are optimised for serial code execution at the expense of parallel execution, which renders them relatively inefficient when it comes to high-performance computing applications. The ever-increasing market demand for high-performance, real-time 3D graphics has evolved the GPU into highly parallel, multithreaded, many-core processor extraordinary computational power and very high memory bandwidth. These vast computational resources of modern GPUs can now be used by the most of the cognitive robotics models as they tend to be inherently parallel. Various interesting and insightful cognitive models were developed and addressed important scientific questions concerning action-language acquisition and computer vision. While they have provided us with important scientific insights, their complexity and application has not improved much over the last years. The experimental tasks as well as the scale of these models are often minimised to avoid excessive training times that grow exponentially with the number of neurons and the training data. However, this impedes further progress and development of complex neurocontrollers that would be able to take the cognitive robotics research a step closer to reaching the ultimate goal of creating intelligent machines. This presentation shows several cases where the application of the GPU computing on cognitive robotics algorithms resulted in the development of large-scale neurocontrollers of previously unseen complexity, which enabled conducting the novel experiments described herein.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
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Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
7. Project Motivation
• A lot of people cannot imagine how this system
will be done and used.
• This project not really popular in Egypt “till
now”.
• Recently, intense research has been conducted in
BCI technology
7
8. Project Motivation cont.
• And now many projects reach the levels of
success originally touted.
• We will deal with new technology and
implement it by using new techniques.
8
9. System architecture
Signal
Preprocessing Feature Extraction
Acquisition
Decision Classification
9
10. System Acquisition
How to explore brain activity?
Invasive Noninvasive
10
11. EMOTIV Headset
• The EMOTIV Headset (EPOC) has 14 electrodes
(compared to the 19 electrodes of a standard
medical EEG).
• We use only 5 channels (AF3-F7-F3-FC5-P7)
11
12. Preprocessing
• there are two purpose for preprocessing
KeepRemove artifacts signals: certain frequency
interest in EEG signals in
band(0.5-45)
Band Pass Filter
Biological Environmental
12
14. Fourier
provides a signal which is localized
only in the Frequency domain.
Features are magnitude values for the
specified spectral range of frequencies
Ex: 1-Range(8-30) = 23 features for each channel
2-Top Ten Frequencies for each channel 14
15. Wavelet packet decomposition WPD:
• Is localized in both time and frequency
•Divided signal into component according to time
•Parameters : according to the required Band and the
sampling rate we select the number of levels for our
WPD
•Features : Mu-Sigma-Min-Max-Epsilon (30 features for
each channel)
15
16. Principal Components
Analysis
• It is a way of identifying patterns in data,
and expressing the data in such a way as
to highlight their similarities and
differences
• The other main advantage of PCA is that
once you have found these patterns in
the data, and you compress the data
without much loss of information.
• (5 features for each channel)
16
17. Classification
In this step we need to classify the signal to detect
the Arm motion
Neural Networks
• A type of artificial intelligence that
attempts to imitate the way a human
brain works. Rather than using a digital
model.
17
21. Future Work
• Add more movements of different parts of the
body
• Get the data from emotive headset to the arm
directly using wireless connection
• Implement the program on a microcontroller
in the arm
21
22. References
[1] R. Palaniappan and D. P. Mandic. EEG based biometric framework for automatic identity
verification. Journal of VLSI Signal Processing
Systems, 49(2):243–250, 2007.
[2] R. Palaniappan and K. Ravi. Improving visual evoked potential feature classification for
person recognition using PCA and normalization.
Pattern Recognition Letters, 27(7):726 – 733, 2006.
[3] R. Paranjape, J. Mahovsky, L. Benedicenti, and Z. Koles’. The electroencephalogram as a
biometric. In Canadian Conference on Electrical and Computer Engineering, volume 2,
pages 1363 –1366, 2001.
[4] M. Poulos, M. Rangoussi, V. Chrissikopoulos, and A. Evangelou. Parametric person
identification from the EEG using computational
geometry. volume 2, pages 1005 –1008, Pafos, Cyprus, 1999.
[5] M. Poulos, M. Rangoussi, V. Chrissikopoulos, and A. Evangelou. Person identification based
on parametric processing of the EEG. volume 1, pages 283 –286, Pafos, Cyprus, 1999.
22
The brain activity can be monitored via several methods, which can beclassified as invasive and noninvasive. The invasive method need to permanently implant devices in the brain which generated many risks and itis not feasible in particle applications. The noninvasive methods includemagnetoencephalography (MEG), functional magnetic resonance imaging(fMRI), positron emission tomography (PET), optical imaging and electroencephalography (EEG).