This document discusses the basic principles of cell injury and adaptation. It defines key terms like disease, disorder, inflammation, and immunity. It explains homeostasis and the body's feedback systems that maintain equilibrium. Regarding cell injury, it describes how physical, chemical, or biological insults can cause reversible or irreversible damage depending on the severity and duration of the stress. The causes of cell injury include genetic factors, nutritional deficiencies, immune reactions, endocrine imbalances, physical and chemical agents, infections, and ischemia.
Catabolism of Purine Nucleotides | Hyperuricemia | Goutkiransharma204
This PPT contains topic on Catabolism of purine nucleotides, Hyperuricemia and Gout.
Book referred: https://www.amazon.in/BIOCHEMISTRY-SATYANARAYANA-5TH-2017/dp/B073Y7XGH4
Catabolism of Heme | Jaundice | Hyperbilirubinemiakiransharma204
This PPT contain topics on Catabolism of heme; hyperbilirubinemia and jaundice
Books referred: https://www.amazon.in/Biochemistry-2019-Satyanarayana-Satyanarayana-Author/dp/B07WGHCTKZ/ref=sr_1_1?dchild=1&qid=1592209115&refinements=p_27%3AU+Satyanarayana&s=books&sr=1-1
Basic principles of Cell injury and AdaptationAkshayYadav176
Basic principles of Cell injury and Adaptation:
(As per new syllabus of PCI)
Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury,Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis & Alkalosis,Electrolyte imbalance.
A clinical chemistry laboratory, also known as a medical laboratory, is a specialized facility that performs diagnostic testing and biochemical analysis to support healthcare and patient care. It plays a crucial role in pathology and laboratory medicine by examining blood samples, body fluids, and other specimens to measure various analytes. The laboratory utilizes a range of analytical techniques, including immunoassays, spectrophotometry, chromatography, and electrophoresis, to accurately measure and interpret test results. Common tests performed in the clinical chemistry laboratory include liver and kidney function tests, lipid profiles, glucose testing, electrolyte testing, hormone assays, therapeutic drug monitoring, toxicology screening, tumor markers, and cardiac markers. The laboratory also conducts urinalysis, microbiology, serology, hematology, coagulation studies, blood banking, and molecular diagnostics. Quality control, automation, and adherence to regulatory standards ensure accurate and reliable results. The clinical chemistry laboratory supports clinical decision-making, disease diagnosis, treatment monitoring, and contributes to evidence-based medicine and scientific advancements in healthcare.
Catabolism of Purine Nucleotides | Hyperuricemia | Goutkiransharma204
This PPT contains topic on Catabolism of purine nucleotides, Hyperuricemia and Gout.
Book referred: https://www.amazon.in/BIOCHEMISTRY-SATYANARAYANA-5TH-2017/dp/B073Y7XGH4
Catabolism of Heme | Jaundice | Hyperbilirubinemiakiransharma204
This PPT contain topics on Catabolism of heme; hyperbilirubinemia and jaundice
Books referred: https://www.amazon.in/Biochemistry-2019-Satyanarayana-Satyanarayana-Author/dp/B07WGHCTKZ/ref=sr_1_1?dchild=1&qid=1592209115&refinements=p_27%3AU+Satyanarayana&s=books&sr=1-1
Basic principles of Cell injury and AdaptationAkshayYadav176
Basic principles of Cell injury and Adaptation:
(As per new syllabus of PCI)
Introduction, definitions, Homeostasis, Components and Types of Feedback systems, Causes of cellular injury,Pathogenesis (Cell membrane damage, Mitochondrial damage, Ribosome damage, Nuclear damage),Morphology of cell injury – Adaptive changes (Atrophy, Hypertrophy, hyperplasia, Metaplasia, Dysplasia),Cell swelling, Intra cellular accumulation, Calcification, Enzyme leakage and Cell Death Acidosis & Alkalosis,Electrolyte imbalance.
A clinical chemistry laboratory, also known as a medical laboratory, is a specialized facility that performs diagnostic testing and biochemical analysis to support healthcare and patient care. It plays a crucial role in pathology and laboratory medicine by examining blood samples, body fluids, and other specimens to measure various analytes. The laboratory utilizes a range of analytical techniques, including immunoassays, spectrophotometry, chromatography, and electrophoresis, to accurately measure and interpret test results. Common tests performed in the clinical chemistry laboratory include liver and kidney function tests, lipid profiles, glucose testing, electrolyte testing, hormone assays, therapeutic drug monitoring, toxicology screening, tumor markers, and cardiac markers. The laboratory also conducts urinalysis, microbiology, serology, hematology, coagulation studies, blood banking, and molecular diagnostics. Quality control, automation, and adherence to regulatory standards ensure accurate and reliable results. The clinical chemistry laboratory supports clinical decision-making, disease diagnosis, treatment monitoring, and contributes to evidence-based medicine and scientific advancements in healthcare.
1.Biomolecules
Introduction, classification, chemical nature and biological role of
carbohydrate, lipids, nucleic acids, amino acids and proteins. 2.Bioenergetics
Concept of free energy, endergonic and exergonic reaction, Relationship
between free energy, enthalpy and entropy; Redox potential.
Energy rich compounds; classification; biological significances of ATP
and cyclic AMP
PHARMACOGNOSY & Phytochemistry-I (BP405T)Unit-IIPart-2.FACTORS AFFECTING CULTIVATION
1. Altitude
2.Temperature
3. Rainfall
4. Day Length and Day Light
5. Soil
6. Soil Fertility
7. Fertilizers and Manures
a) Chemical fertilizers
(b) Manures
(c) Biofertilizers
8. Pests and Pests Control
a. Microbes
b) Insects
C) Non insect pests
d) Weeds
9. Other Factors that Affect the Cultivated Plants
a. Air Pollution
b. Herbicide
Tryptophan is first hydroxylated to form 5-OH-tryptophan in liver. The reaction is analogous to conversion of Phe - to tyrosine. Liver phenyl alanine hydroxylase also can catalyse hydroxylation of tryptophan. In the next step, 5-OH-tryptophan is decarboxylated, by the enzyme 5-OH-tryptophan decarboxylase, in presence of B6-PO4 to form 5-hydroxy tryptamine (5-HT), also called serotonin. The enzyme is present in kidney, liver and stomach. Aromatic-Lamino acid decarboxylase, widely distributed in tissues can also catalyse this reaction.
THIS SLIDE CONTAIN ABOUT QUALITATIVE TEST, STRUCTURE AND USES OF DIFFERENT CARBONYL COMPOUNDS LIKE FORMALDEHYDE, PARALDEHYDE, ACETONE, CHLORAL HYDRATE, HEXAMINE, BENZALDEHYDE, VANILIN AND CINNAMALDEHYDE
1.Biomolecules
Introduction, classification, chemical nature and biological role of
carbohydrate, lipids, nucleic acids, amino acids and proteins. 2.Bioenergetics
Concept of free energy, endergonic and exergonic reaction, Relationship
between free energy, enthalpy and entropy; Redox potential.
Energy rich compounds; classification; biological significances of ATP
and cyclic AMP
PHARMACOGNOSY & Phytochemistry-I (BP405T)Unit-IIPart-2.FACTORS AFFECTING CULTIVATION
1. Altitude
2.Temperature
3. Rainfall
4. Day Length and Day Light
5. Soil
6. Soil Fertility
7. Fertilizers and Manures
a) Chemical fertilizers
(b) Manures
(c) Biofertilizers
8. Pests and Pests Control
a. Microbes
b) Insects
C) Non insect pests
d) Weeds
9. Other Factors that Affect the Cultivated Plants
a. Air Pollution
b. Herbicide
Tryptophan is first hydroxylated to form 5-OH-tryptophan in liver. The reaction is analogous to conversion of Phe - to tyrosine. Liver phenyl alanine hydroxylase also can catalyse hydroxylation of tryptophan. In the next step, 5-OH-tryptophan is decarboxylated, by the enzyme 5-OH-tryptophan decarboxylase, in presence of B6-PO4 to form 5-hydroxy tryptamine (5-HT), also called serotonin. The enzyme is present in kidney, liver and stomach. Aromatic-Lamino acid decarboxylase, widely distributed in tissues can also catalyse this reaction.
THIS SLIDE CONTAIN ABOUT QUALITATIVE TEST, STRUCTURE AND USES OF DIFFERENT CARBONYL COMPOUNDS LIKE FORMALDEHYDE, PARALDEHYDE, ACETONE, CHLORAL HYDRATE, HEXAMINE, BENZALDEHYDE, VANILIN AND CINNAMALDEHYDE
Homeostasis, feedback mechanism,cellular adaptations
cell injry..etiology...types and its pathogenesis..
morphology of cellinjury
necrosis
calcification
Antimicrobial stewardship to prevent antimicrobial resistanceGovindRankawat1
India is among the nations with the highest burden of bacterial infections.
India is one of the largest consumers of antibiotics worldwide.
India carries one of the largest burdens of drug‑resistant pathogens worldwide.
Highest burden of multidrug‑resistant tuberculosis,
Alarmingly high resistance among Gram‑negative and Gram‑positive bacteria even to newer antimicrobials such as carbapenems.
NDM‑1 ( New Delhi Metallo Beta lactamase 1, an enzyme which inactivates majority of Beta lactam antibiotics including carbapenems) was reported in 2008
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
5. Introduction
● Pathophysiology is the study of biological and physical manifestations of
diseases as the correlate with the underlying abnormalities and
physiological disturbances
● Pathophysiology does not dealing with the treatment of diseases
● Instead it explains about the process within the body and it’s sign and
symptoms
● It’s a advanced field of study beyond anatomy and physiology
● It’s concerned with the study of disease, infections, illness, and dysfunctions
in the human body
7. Definitions
Disease:
● The term Disease refers to any conditions that impairs normal function
● I.e: Functional Abnormality
● It may be cause by external factors such as infectious disease or
● It may be cause by internal factors such as autoimmune disease.
Disorder:
● Anatomical abnormalities or disturbances are known as disorder
● Like Fracture, Alzheimer and Diabetes, etc.,
● Disorders are mainly categories into Mental disorder, Physical disorder, Genetic
disorder, Emotional and Behaviour disorder and Functional disorder.
8. Definitions
Inflammation:
● It is a protective mechanism of the body to remove the injuries or stimuli or
complex biological response of vascular tissue against the harmful stimuli
like pathogen, damaged cells or irritants.
● Inflammation is not the synonyms of infection. But sometimes inflammation
is caused by the infections
Infection:
● Infection means the growth of parasitic organism within the body expect
the normal growth of the usual bacterial flora in the intestinal tract
9. Definitions
Immunity:
● It is the defense mechanism to avoid the infection, disease or other
unwanted biological invasion
11. Homeostasis
● Ability to maintain relatively stable internal conditions despite a changing
external environment.
● Dynamic state of equilibrium or balance
● Body is said to be in homeostasis when it's cellular needs are adequately met
and functional activities are occurring smoothly
● Virtually every organ system plays a role in maintaining the internal
environment
● Homeostasis regulatory mechanism consist of 5 parts
12. Homeostasis
● Ability to maintain relatively stable internal conditions despite a changing
external environment.
● Dynamic state of equilibrium or balance
● Body is said to be in homeostasis when it's cellular needs are adequately met
and functional activities are occurring smoothly
● Virtually every organ system plays a role in maintaining the internal
environment
● Homeostasis regulatory mechanism consist of 5 parts
13. Homeostasis Regulatory Mechanism
Effectors
05
● Effectors are the cell or organ
● That responds according to the command of the control
center via motor receptor
Motor Receptor
04
● It send the reply coming from integrated center to
effector
Integrated Center
03
● It analyze the incoming message and send the reply via
motor receptor (Brain and Spinal Cord)
Sensory Neurons
02
● It receives information from receptor and sends input
messages to integrated center
Receptors
01
● It responds to a stimulus
● It monitors the change in control condition and send the
input information to control center/ Integrated center via
sensory receptors
16. Negative Feedback System
When the response of effectors opposes the original stimulus, it is called Negative
Feedback because its neglect the stimulus
An example for the negative feedback system is thermostat in home
Temperature sensors turn on and off to maintain the air temperature within a
specific range, condition range
In the same way our body homeostasis mechanism control our body temperature
17. Negative Feedback System
● Some stimulus (Stress) disrupts homeostasis (Control Condition) by an
increasing in body temperature
● Due to this thermoreceptors (Temperature sensitive receptors) in the skin and
brain activate and send input message through nerve impulse to the control
center
● Control center analyze the input message and send output message to effectors
(Skin).
18. Negative Feedback System
● Effectors according to output message of control center increases sweating from
sweat glands causes increased heat loss by evaporation
● Finally, decreases the temperature in the form of response and normalize the
body temperature (Control Condition)
19. Positive Feedback System
The effectors add to the initial stimulus instead of negativen it, speeding up the
process.
● Labor contraction is the best example for the Positive Feedback System
● Labor contraction force baby’s head or body into birth canal
● It produces effect on control condition and increase distension of cervix of
uterus
● It activates the stretch receptors of the cervix and send input messages to the
control center through sensory nerve impulse
20. Positive Feedback System
● Control center activates the hypothalamus and pituitary gland and send the
output message to increase oxytocin secretion in blood
● Oxytocin produces their effect on to the effector (cervix of uterus) and cause
distension of cervix of uterus than the normal value to push the baby further
into birth canal
● Birth of baby decreases distension of cervix of uterus and interrupts Positive
Feedback Cycle
22. Cell Injury
● Cell injury occurs as a results of Physical, Chemical or Biological insults or as
results of vital substrate deficiency
● The term cell injury is used to indicate a state in which the capacity for
physiological adaptation is exceeded.
● This may occur when the stimulus is excessive or when the cell is no longer
capable to adapt without suffering some form of damage.
23. Cell Injury
● The capacity for adaptation and the sensitivity to different types of injury varies
according to cell type (i.e: Myocardial Cells and Neurons are highly sensitive to
ischemic injury)
● Cell injury may be Reversible (Non-lethal damage which generally can be
corrected by removal of stimulus) or Irreversible (Lethal damage)
● Genetic defect, abnormalities of several dietary factors, immune reaction,
physical or chemical agent may cause the cell injury
● Commonly Ischemia and Hypoxia are the two forms of cell injury
24. Reversible Cell Injury
If the hypoxic or ischemic effect is for short duration then it produce reversible cell
injury because this kind of effect is restore by the vascular circulation.
Example:
● Coronary artery occlusion and
● Myocardial contractility, etc.,
25. Reversible Cell Injury
Some of the sequential biochemical and ultrastructural changes in reversible cell
injury as follows
1. Depletion of ATP
2. Intracellular lactic acidosis and nuclear clumping
3. Effect on plasma membrane
a. Failure of Na+ - K+ ATPase pump
b. Failure of Ca++ pump
4. Decrease Protein Synthesis
26. 1. Depletion of ATP
● ATP is the primary requirement for synthesis of protein, lipid and cell
membrane, etc.,
● In human body ATP is produced by aerobic and anaerobic process.
● Aerobic is carried out by the mitochondria whereas anaerobic carried out by
glucose/glycogen
● In the ischemic condition, supply of oxygen and glucose both are get affected
● So decrease in the production of ATP results in fail in the production of
protein, lipid and cell membrane, etc., leads to cell injury
27. 1. Depletion of ATP
● In hypoxia, due to lack of oxygen supply there will be a formation of demand
● This may due to RBC disorder, Heart disease, Lung disease will form
● Generally anaerobic cell injury are less when compared with aerobic
28. 2. Intracellular lactic acidosis and nuclear clumping
● Due to low oxygen supply aerobic ATP formation process get affected and
mitochondria fails to work
● So anaerobic glycolytic pathway start to produce ATP
● This results in rapid depletion of glycogen and accumulate lactic acid
● It lower the intracellular pH due to intracellular acidosis and produce
clumping of nuclear chromatin
● This effect release the lysosomes and it produce cellular digestion
29. 3. Effect on plasma membrane
● Plasma membrane required phospholipid for continuous repair but due to
lack of ATP fatty acid not form the phospholipids
● Due to this effect plasma membrane pumps get affected and the regulation
of calcium, sodium and potassium get affected
a. Failure of Na+ - K+ ATPase pump
b. Failure of Ca++ pump
30. a. Failure of Na+ - K+ ATPase pump
● Na+ - K+ ATPase pump is useful for the exchange of Na+ inside to outside and K+
outside to inside from the cell
● Lower ATP affect the activity of this pump and Na+ get accumulate inside the cell
and K+ outside of the cell
● Accumulation of Na+ inside the cell retain the water and increase intracellular
water level and hydrophobic swelling occur due to disruption in osmotic
pressure
31. b. Failure of Ca++ pump
● Accumulation of Na+ inside the cell produce affect in the intracellular level of
Ca++
● Excess Ca++ accumulate inside the cell as well as into the mitochondria leads
to reversible cell damage
32. 4. Decrease Protein Synthesis
● Lack of oxygen effect disturb the intracellular osmotic balance of the cell
● So endoplasmic reticulum and golgi apparatus swell up
● So the ribosome detach from the granular endoplasmic reticulum and it get
inactive
● This effect decreases the synthesis of protein
33. Irreversible Cell Injury
● Long lasting/persistence ischemic or hypoxic effect produce cell death or
irreversible damage.
● If cells fails to reverse mitochondrial function as well as disturbance in cell
membrane/ plasma membrane function cause irreversible cell injury
It’s of two types
I. Ca+ influx produce excitotoxicity into the cell
a. Effect of activated phospholipase
b. Effect of activated protease
c. Effect of activated endonuclease
II. Low pH of cell activate and release the lysosomal hydrolytic enzyme
34. I. Ca+ influx produce excitotoxicity into the cell
Large amount of intracellular Ca++ produce damage in mitochondrial cell wall as well
as excitotoxicity (Activation of number of enzymes like phospholipase, endonuclease
and protease, etc.,)
This effect damage the cell structure such as component of cytoskeleton, plasma
membrane and DNA etc.,
35. a. Effect of activated phospholipase
● Activated phospholipase degrade the membrane phospholipids which is the
main constituents of plasma membrane.
● As well as due to lack of ATP generation new phospholipid will not form and it
aggregate the effects.
36. b. Effect of activated protease
● Activated protease damage the cytoskeleton of the cell membrane leads to
irreversible cell injury
c. Effect of activated endonuclease
● Activated endonuclease damages the nucleoprotein as per below process
○ Condense or clumps the nucleus
○ Produce fragments of nucleus
○ Dissolve the nucleus
37. II. Low pH of cell activate and release the
lysosomal hydrolytic enzyme
● Lack of oxygen decrease the intracellular pH and it activate or release the
lysosomal hydrolytic enzyme like Lactic Dehydrogenase (LDH), Creatinine
Kinase (CK), hydrolyse RNAse, DNAse, Glycosidase, Phosphatase, Lipase,
Amylase, Cathepsin, Etc.,
● Activation of this enzyme digest the cellular components through the phagocytic
effects and cause the irreversible cell injury.
39. Causes of Cell Injury
Types:
1. Genetic - Gene defects, Chromosomal Abnormalities
2. Nutritional - Deficiency or excess of dietary substance, e.g - Iron, Vitamins
3. Immune - Immune system works for foreign agents in some cases it will
destroy the own cell . Example: a. Anaphylactic Reaction b. Autoimmune
4. Endocrine - Deficient or excessive hormone activity
5. Physical Agents - Mechanical trauma, Thermal damage, Irritation (UV and
Ionizing)
40. Causes of Cell Injury
Types:
6. Chemical Agents - The chemicals provided in the following may cause cell and
tissue injury. Eg: Poisons - Arsenic, Cyanide, Mercuric Salts, Air Pollutants,
Insecticide, Herbicide, Alcohol, Narcotic drugs
7. Infective - Infection by virus, bacteria, parasites, fungi, and other organisms,
8. Ischemia (Hypoxia) - Deficit of blood supply or Direct oxygen deficit