This document discusses the evaluation and treatment of low back pain. It notes that low back pain is very common, affecting 90% of people and costing $40 billion annually. For acute low back pain, the short answer is to leave patients alone and for chronic pain, recommend back classes and functional rehabilitation. Red flags to evaluate for include cancer, infection, or neurological deficits. The goal is to distinguish the 95% with simple back pain from the 5% with serious underlying issues. Conservative treatment is usually sufficient, with opioids not recommended for chronic pain due to lack of evidence of long-term benefit and risk of harm.
April 11, 2018
With growing neuroscientific research on sports concussions, states have revised their policies and statutes. Yet at present we have limited research on how these state sports concussion laws are working. This panel explored the intersection of neuroscience and law in the context of preventing, detecting, and treating youth sports concussions.
For more information, visit our website at: http://petrieflom.law.harvard.edu/events/details/how-to-fix-youth-sports-concussion-laws
April 11, 2018
With growing neuroscientific research on sports concussions, states have revised their policies and statutes. Yet at present we have limited research on how these state sports concussion laws are working. This panel explored the intersection of neuroscience and law in the context of preventing, detecting, and treating youth sports concussions.
For more information, visit our website at: http://petrieflom.law.harvard.edu/events/details/how-to-fix-youth-sports-concussion-laws
This presentation is a comprehensive summary about all aspects of back pain. Back pain is one of the most common orthopaedic morbidity or orthopedic disability. Sciatica and lumbar disc diseases are common cause of spinal disability. Back pain are divided into Red flags, green flags and yellow flags for quick clinical screening. both treatment, prevention aspects are covered. Spinal anatomy and Biomechanics are covered. Epidemiology and role of various types of spine surgery, microdiscectomy, endoscopic spine surgery are also described.
Musculoskeletal Health Concerns of the Aging PopulationAllan Corpuz
A lecture on low back pain, osteoarthritis and soft tissue rheumatisms delivered to nurses, nursing attendants and institutional workers at the the Philippine General Hospital
A presentation made by Dr. Andrew Knight during the free public forum "Continuing the Conversation: a discussion on preparing for end-of-life care" on February 6, 2014 at the United Steelworkers Hall in Sudbury, Ontario.
Dr. Knight is a General Practitioner at the Northeast Cancer Centre and he is the Education Co-chair of the Palliative Care Education Committee and is an Assistant Professor of Family Medicine at the Northern Ontario School of Medicine. He is a Past Chair of the Canadian Association of General Practitioners in Oncology (CAGPO) and is currently the Palliative Care Lead for LHIN 13.
Learn more about the forum at http://www.hsnsudbury.ca/events
Treating virtual symptoms Functionality in MS - Wojciech PietkiewiczMS Trust
Objectives:
To be able to tell with good probability what is organic and what is not in your MS patient
To be able to understand where non-organic problems come from
To be able to tell the diagnosis to the patient
To know how to approach the condition
To make sense of the idea of psychosomatic disease
Evaluation of Lumbar Spine Disease starts with understanding the clinical back grounds. It starts with good history and physical examination. This is a teaching lecture given twice by Prof. Dr. Mohamed Mohi Eldin, professor of neurosurgery, in the Basic Spine Course, Egyptian Medical Syndicate, Cairo, March 2009 and in 2010.
Best Ayurvedic medicine for Gas and IndigestionSwastikAyurveda
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
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The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. Objectives
• recognize non musculoskeletal back pain
• recognize syndrome of HNP
• be able to treat muscular back strain
3. Cases – think about these
• 59 yo woman c breast ca and new onset
spine pain
• 60 yo man c 7 yrs of chronic back pain here
for norco
• 30 yo PA with severe back/leg pain after
dragging moose out to road after hunting in
Montana
4. So What ?
• prevalence 90%
• annual cost 40 billion dollars (some years
ago)
• #2 reason for missed work
• #1 cause of workman’s comp
• most common symptom for outpatient
X-Rays
5. Short answer on how to treat
• Acute – leave them alone
• Chronic- back class/functional rehab
6. Why do doctors hate seeing back
pain?
• No easy fix
• patients unhappy
• MD ignorance of topic
• Cannot refer difficult pts away to
ortho/rheum/PMR/pain…
7. Origin of ignorance
• Not taught in med school
• Teachers there do not see it
• Not part of internal medicine
8. Common misconceptions
• usually a surgical problem
• precise diagnosis possible in most patients-
perhaps only 15%
• prolonged bedrest as treatment mainstay
• surgical indications clear
9. Anatomy - the articular triad
• intervertebral joint-hyaline cartilage
endplate separated by
– nucleus pulposus-shock absorbing ball bearing
– annulus fibrosis-elastic support of nucleus
• 2 posterior facet joints-guide, steady, and
limit motion
10.
11. Disease process for “ordinary”
back strain
• with normal aging nucleus desiccates
• no longer acts as shock absorber and ball
bearing
• leads to DJD of facet joints
12. Disease process for herniated
nucleus pulposus
• annulus weakens as nucleus fails
• annulus rupture and nucleus protrudes
• nerve root occasionally struck-L4, L5, S1
• cauda equina can be injured if posterior
longitudinal ligament weak
• nucleus eventual shrinks
13. Goal
separate the simple back pain in 95%
from the 5% who have a serious
underlying disease (whether spinal or
referred) or neurologic impairment.
14. Approach
• systemic disease (possibly referred pain)
involved?
• neurologic deficits present?
• Is there social or psychologic distress which
may prolong or amplify the pain
15. Simplified differential diagnosis
• terms not precise or accurate
• “back strain”
• “sciatica”-herniated disc with nerve
compression
• other/systemic disease e.g.. ca,
infection,compression fx
• consider referred pain (e.g.. pyelo,
pancreatitis, AAA)
16. The understanding of back
disorders has been impaired by
the overemphasis of the
syndrome of HNP- only 5%
18. The history usually eliminates
systemic causes
• personal hx of cancer? weight loss? fever?
• is pain worse with rest and better with
activity?
• does pain wake patient up at night?
• hx IVDA or recent UTI?
• age over 50?
19. Pre test probabilities of diseases
• from 1 October 2002 Annals
• cancer 0.7%
• infection .01%
20. History
• chronological association with illness,
injury, or job
• character of pain
• severity-ability to work, confined to bed,
interfere with sleep?
• early awareness of substance abuse,
depression, and legal issues=roadblocks to
improvement
26. Physical
• observe gait for weakness and inconsistency
• inspect
• palpate
• the above are low yield but useful in that
patients like to be examined. Gives them
confidence in you- KEY
34. Straight leg raise
• Lift leg by heels and if pain mentioned ask
location
• Must be leg pain from 30-70 degrees
• Good test –excludes radiculopathy esp pts
under 30
36. Turkey tests
• hysteric patients
• “coached” by previous exams
• malingering
• use SLR variations
37. What about plain X Ray films?
• not needed in first 4-6 weeks unless
suspicious for secondary cause
• used to help exclude tumor or infection
• oblique films not needed
38. Other studies
• MRI if considering operation,
infection, or cancer
• ESR? if suspicious for serious
diseases
39. Rx for acute back strain
• remember 90% better in six weeks-if do
nothing
• bedrest 2-3 days at most
• wt loss, abd exercise, stretch, posture,
Tylenol/NSAIA, aerobic exercise
• PT if needed to reinforce the above
• discourage illness/disability behavior
40. Patient education
• most get better slowly
• realize there is no cure
• they cannot be passive participants
• surgery will not help most
41. Rx no red flags
• educate
• Tylenol
• back care
• exercise
• wait-follow
42. What about “muscle relaxants?”
• which drugs are?
• do they work?
• cost?
• why used?
43. Rx red flags
• ESR?
• Plain films
• MRI/CT
• consult others
44. Operative management
• loss of bowel and bladder function
• Radiculopathy-intractable pain?
• Radiculopathy-progressive neurologic
changes?
45. Operative results
• pain relief? no difference at 4 yr... between
op or not
• neuro deficits? no difference at one yr.......
• MMPI best predictor in one study
46. Best candidates
• emotionally stable
• need to get well soon
• most common cause of failure is poor
patient selection
47. Concise treatment algorithm
• If cauda equina syndrome or hemodynamic
collapse (AAA) are present- go to the OR
• If constitutional symptoms are present then
evaluate medically
• Otherwise conservative treatment for six
weeks
48. Acute low back pain
• recognize the patients with a systemic
disease or HNP
• effectively treat 90%
49. Chronic back pain- the 10%
• Not infection or cancer as have had for
years
• Manage expectations
• Back class/work hardening/functional rehab
• Try drugs
50. Expectations are KEY
• No easy cure
• Not possible to be rid of all pain
• Dr Cox “If you are 50 and do not ache, you
are dead.”
• Opiates? Pain /drug lobby- ok for post op?
51. Opiates
• US 5% of global pop uses 80% of opiate rx
• No data on utility for 1 yr, most trials 6 wks
yet given forever
• Feb 17, 2015 Annals had no useful
conclusions on the NIH Workshop or Lit
review of opiates for chronic pain
52. Opiates
• ER/other doctors- give so the pt will go
away fast
• Street value $10-20 pill for norco
• Tylenol #3 less-no euphoria
53. Useful tips
• Psyche, pain in more than 3 areas,
substance abuse hx =high risk
• Do not let pts negotiate- they will wear
your down
• Wean down dose, withdrawal can be
unpleasant
54. More ideas
• “but I have had it for years” opiates are for
acute pain not chronic pain – down
regulation of receptors idea/hyperalgesia
• “My previous doctor gave it to me” – no
long term benefit ever shown and known
harms
55. Best use of norco
• When there is functional improvement
• Pt returns to work
• Not so they will be buzzed lying on the sofa
• Limited number of pills for elderly OA and
not surgical candidates
56. Is there an answer? My opinions
• Reinforce no rapid easy cure
• Use central acting agents like
TCA/cymbalta- gate control pain theory
• I use D Day example- non-mortal wounds
often had less pain , knew they would go
home
• Treat depression-if present key
• Weight loss-easy to say
• Back class
57. Back class
• Work hardening
• Not PT in sense of massage/ultrasound
• Core strengthening, mobility
• Only answer I know
• Up to pts whether they want to get better