Dr. Steenblock specializes in treating patients with Atherosclerosis and other similar conditions using Stem Cell Treatments. He uses bone marrow stem cells, adipose (fat) stem cells and umbilical cord stem cells. For more information call his office Today! 1-800-300-1063. Websites: www.stemcellmd.org www.strokedoctor.com www.stemcelltherapies.org www.cerebralpalsycure.com www.davidsteenblock.com www.davidsteenblock.net

1. You are Only As Oldas Your Arteries!ByDavid A Steenblock, DO26381 Crown Valley ParkwayMission Viejo, CA 92691800-300-1063www.stemcell.md

2. In tribute to Sir William Osler, M.D., First Director of Medicine, Johns Hopkins Hospital“A man is only as old as his arteries.”

4. Creates ischemic conditions for the heart, brain, legs, kidneys and other organs, resulting in disease and degeneration.

5. Athero from the Greek word “gruel” (cholesterol/fat deposits) Sclerosis from Greek for “hardness” (collagen calcification, usually 70% of plaque)

7. Smoking

8. Serum total cholesterol

9. Diabetes

10. Obesity

11. Sedentary Lifestyle

12. Menopause in women

13. “sticky platelets”

15. Red Blood cells(erythrocytes) transport oxygen to the cells and carry carbon dioxide (cellular waste) back to the lungs to be exhaled.

16. Arteries are large blood vessels that carry oxygenated blood from the heart to the brain, limbs and organs.

17. Veins are large blood vessels that carry de-oxygenated blood back to the heart.

18. Capillaries are microscopic blood vessels having only one layer of endothelial cells as a wall so that oxygen and nutrients can move into the cells and carbon dioxide can move into capillaries and be carried away.

19. The Artery Wall should expand and contract with the heartbeat. Adventitia – outer wall (connective tissue) Media – elastic middle layer (smooth muscle cells) Intima – endothelial layer (inflammation creates intimal thickening) Lumen – opening where blood flows

21. Sense the blood pressure and flow rate and release nitric oxide to relax the vessel walls to allow more blood to flow through.

22. Sense vascular injury and stimulates growth factors to migrate to the area of injury.

26. Chemical toxins (pesticides, etc)

27. Heavy metals (mercury, lead, cadmium)

28. Tobacco

29. Cholesterol, especially oxidized LDL and VLDL

31. Homocysteine

33. The injury damages the endothelial cells allowing free radicals, lipids, calcium and cholesterol to penetrate into the inner muscular (middle) layer

34. The free radicals oxidize LDL and VLDL cholesterol, creating a chain reaction of cellular damage.

37. Earliest lesion in arterioslcerosis

38. Mostly lipid engulfed macrophages with occasional lipid filled smooth muscle cells

40. This combination of foam cells, calcification, and lipids is called “atherosclerotic plaque.”

42. An Aneurysm of the Abdominal Aorta

43. As the arteries become clogged- blood, oxygen and nutrients are unable to reach the heart, brain, kidneys and other organs. A heart attack or stroke is the result of these blockages!

44. Arteriosclerosis and Systemic Disease

45. Ischemia – lack of blood flowHypoxia – lack of oxygen Most diseases can be attributed directly or indirectly to ischemia, a lack of blood flow to the cell. Reducing the risk factors for cardiovascular disease reduces other atherosclerotic disease outcomes as well.

46. Ischemia and the Heart Since oxygen is the fuel needed for muscles to contract, a reduction in blood flow and oxygen to the heart interferes with its contractions. A heart muscle starved of oxygen produces pain (angina) and is less able to pump blood efficiently to the body, especially during exercise (shortness of breath, dizziness, headache, pain in the leg muscles).

48. Arrythmia (irregularities such as PVC’s, atrial fibrillation, skips, flutters, etc)

49. Angina (chest and/or left arm pain, etc)

50. Shortness of breath

51. Blockage of the left main coronary artery is the worst and often kills.(American Journal of Medicine, 1996, 101 (Suppl 4A): 17S-24S).

52. Arteriosclerosis and the Brain 1) Causes transient ischemic attacks 2) Causes the majority of all strokes 3) Stroke is the third leading cause of death in USA 4) Lack of oxygen is a cause of memory loss, loss of clear thinking, brain fog, poor mental functioning, confusion, forgetfulness and difficulty concentrating (cognitive dysfunction). 5) Causes vascular dementia while most cases of Alzheimer’s are partially due to oxygen deficiency. 6) Lack of oxygen occurs at night in a very great number of people who don’t realize they have the problem. All of the problems listed under number 4 can occur. Insist that your doctor order a Nocturnal oximetry test! It is free and could save your life!!!!!!!!

53. Alzheimer’s Disease Chronic cerebrovascular ischemia (chronic lack of oxygen to the brain) produces an increased risk for the development of Alzheimer’s Disease, with observed deficits in spatial memory (CA1 and posterior parietal cortex), visually guided movements (superior colliculus and secondary visual cortex), motor coordination (red nucleus), and escape behavior (central gray). (Neurobiology of Aging 21: 225-233, 2000)

54. Alzheimer’s Disease(continued) Vascular risk factors linked to cerebrovascular disease and stroke in the elderly significantly increase the risk of developing Alzheimer’s Disease. These include atherosclerosis, atrial fibrillation, coronary artery disease, hypertension, and diabetes mellitus. The authors report that 60-90% of AD autopsy cases exhibit cerebrovascular pathology. (Neurobiology of Aging, 21: 321-330, 2000)

55. Ischemia and Parkinsons’ Disease A transient reduction in cerebral blood flow in rats produces long-lasting degeneration and dysfunction in the dopamine system and eventually the partial loss of striatal D1RmRNA. (Brain Research, 851, 235-246, 1999)

56. Ischemia andMacular Degeneration Macular degeneration is the leading cause of irreversible visual loss in the United States. The authors used Doppler Imaging to show reduced blood flow in the central retinal artery. (American Journal of Ophthalmology, 128: 75-80, 1999)

57. Macular degeneration Improved greatly with hyperbaric oxygen, external counterpulsation, periodic acceleration therapy, chelation therapy, night time oxygen, eradication of chronic sinusitis, bone marrow and or fat stem cells. All of these work by increasing the oxygen to the macula!

58. Ischemia and Sexual Performance Atherosclerosis is a risk factor for erectile dysfunction (ED). Future therapeutic targets to treat or prevent ED may include the reduction of the atherosclerotic plaque size and progression. Stem cells now are being used successfully to treat erectile dysfunction!

59. Ischemia andArthritis Jonsson and coworkers found an increased prevalence of atherosclerosis in patients with medium term rheumatoid arthritis. (J Rheumatol, 28(12): 2597-602, 2001)

60. Kidney Failure Homma and coworkers showed marked atherosclerosis associated with end-stage renal disease. (American Journal of Nephrology, 21(5): 415-9, 2001).

61. Renal Arteries andCoronary Arteries Shen and coworkers found a prevalence of renal artery stenosis in patients with coronary artery disease. (Zhonghua Nei Ke Za Hi, 40(8): 521-4, 2001 – Chinese)

63. Hyperbaric Oxygen Therapy

64. Pulsed Electromagnetic Therapy

65. External Counterpulsation

66. High Altitude Cardiovascular Training

67. Periodic Acceleration Therapy

68. Chelation Therapy

69. Biofeedback/Neuro-biofeedback

70. Nutritional and Hormonal Therapies

72. Benefits The combination of breathing oxygen through the mask and the chamber pressure causes two to three times the oxygen to be delivered to the blood vessel walls and organ tissues compared to breathing oxygen by the mask alone.

74. Releases Stem Cells from bones

75. New blood vessel formation

76. Improved infection control

77. Renewal of injured cells and organs

81. Air embolism

82. Poisoning

83. Treatment of infections

84. Non-healing wounds in Plastic and reconstructive surgery

85. Traumatic injuries

86. Non-union of fractures

88. Neurological disorders: Stroke, multiple sclerosis, migraine, cerebral edema, multi-infarct dementia, spinal cord injury, brain abscess, peripheral neuropathy, coma

89. Ophthalmology: Macular Degeneration, retinal artery occlusion

91. Otorhinolaryngology: Sudden deafness, acute acoustic trauma, Meniere’s disease, malignant otitis externa (chronic infection)

92. Asphyxiation: drowning, smoke inhalation

94. Increases blood flow to injured cells

95. Stimulates the growth of neurons

96. Stimulates endogenous stem cell production

98. External Counterpulsation The ECP is an exciting technology that is a safe, non-invasive method of improving circulation to the heart, brain, kidneys and other organs, and its benefits can be maintained 4-7 years after the therapeutic program.

100. ECP (continued) Until recently, the predominant treatment for ischemic heart disease was open heart bypass surgery. This treatment is costly, invasive, and associated with complications that include blood clots, infection and a 4% mortality rate. In addition the health benefits of this surgical procedure are often temporary.

101. ECP (continued) The ECP is an outstanding alternative for the person who cannot or will not have a bypass and the device produces numerous benefits to the ischemic heart, brain, kidneys and entire system. The equipment is safe, effective, and generally well tolerated, with few side effects or discomfort to the patient.

103. Increases the resting phase of the heart beat, which promotes greater oxygenation to the heart

104. Increased cardiac output to brain and other organs without increasing the heart rate.

105. Reduces peripheral resistance, thereby reducing the heart’s workload.

107. Reduces ventricular fibrillation (rapid, convulsive movements of the heart muscles)

108. Improves myocardial lactate removal (reduces fatigue)

109. Increases exercise tolerance

110. Reduces the risk of heart attack

111. Reduces the need for anti-anginal medication

112. Improves the person’s sense of well-being and overall quality of life. (American Journal of Cardiology, 1995, 75: 840-841)

113. ECP (continued) In 1995, Lawson published a three year follow-up of 10 patients treated treated for chronic angina with ECP. Eight continued to demonstrate improved myocardial circulation. Lawson concluded that long term improvement in myocardial perfusion and exercise tolerance can occur several years after ECP therapy, probably due to its promotion of collateral circulation. (American Journal of Cardiology, 1995, 75: 840-41)

114. ECP (continued) In 1997, Fricchione studied the psychological aspects of external counterpulsation and found that the treatment significantly improved depression scores. Patients often report feeling depressed after invasive procedures. Since depression is associated with poor outcome in those with cardiac disease, external counterpulsation offers clinical advantages beyond its circulatory benefits. (Cardiovascular Reviews and Reports, 1997, 18: 37-41)

115. ECP (continued) Soran and associates found that patients who responded favorably to therapy with ECP showed a significant increase in circulating vascular endothelial growth factor (VEGF) which promotes endothelial cell migration and collateral blood vessel growth. VEGF stimulates stem cells to grow. (Clinical Cardiology, 1999, 22: 173-178)

116. High Altitude Endurance Training High mountain air is deficient in oxygen and causes the body to become oxygen starved similar to what happens with running a mile or two. This temporary decrease in oxygen stimulates the cells of the body to work harder and more efficiently in the utilization of oxygen. Stem cells are released from the bone marrow as a result of this therapy!

117. High Altitude Training(continued) Cells have small energy producing factories contained within them called “mitochondria.” Mitochondria tend to shrink in size, become damaged and inefficient in their processing of food into energy as we become older and more diseased. This loss of energy is the cause of fatigue, loss of strength, loss of heart function, brain function, etc. associated with aging.

118. High Altitude Training(continued) Intermittent mountain air stimulates the growth, proliferation and repair of these aging, sluggish mitochondria. The body becomes more energized and a great number of diseases and conditions are alleviated. The body “adapts” to short periods of less oxygen by becoming stronger.

120. Hypertension

121. Chronic fatigue syndrome

122. Chronic bronchitis

123. Asthma

124. Ulcerative diseases of the stomach and duodenum

125. Diseases of Locomotion

128. Increase the production of new stem cells

129. Increase red blood cell production

130. Improve immune function

131. Improve endurance

133. Reduce blood pressure and heart rate

134. Increase vital lung capacity

135. Protect the brain from physical and emotional stress (oxidative stress)

136. Promote serotonin and dopamine levels for psychological well-being

137. Promote ability to sleep through the night

139. Chelation Therapy(continued) EDTA is a synthetic amino acid that chelates ( Greek for “to claw” or grab) with metals and carries them safely out of the body. In binding with ionic metal catalysts, EDTA reduces the production of oxygen free radical molecules and prevents a subsequent destructive chain reaction with other molecules.

140. Chelation Therapy(continued) EDTA chelation is endorsed for the treatment of atherosclerotic vascular disease by the American College for Advancement in Medicine (ACAM), comprising of over 1,000 licensed physicians. It’s proponents claim that EDTA consistently improves blood flow and relieves symptoms associated with atherosclerosis in over 80% of the patients treated.

143. Reduction of liver produced cholesterol

144. Lowered insulin requirements in diabetics

145. Reduced blood pressure

146. Normalization of cardiac arrhythmias

147. Relief from leg muscle cramps

148. Lessened varicose vein pigmentation

149. Hair loss stopped and reversed

150. Alzheimer symptoms ameliorated or reversed

151. Memory and concentration improved(Cranton, E.M. J Adv Med, 1989, 2: 1-416)

152. Nutritional Therapies Elevated total cholesterol, homocysteine, and free radical reactions (lipid peroxidation) play a role in several major disorders including hypertension, coronary heart disease, stroke, diabetes, Alzheimer’s Disease, and arthritis.

153. Nutritional Therapies(continued) Oxidative stress and Alzheimer’s Disease: Because lipid peroxidation precedes amyloid plaque formation in mice, this suggests that brain oxidative damage contributes to AD pathogenesis before A beta accumulation in the AD brain. (Journal of Neuroscience, 2001, 21(12): 4183-7)

155. Nutritional Therapies(continued) Free Radical Reactions: An unpaired electron can break apart the weak bonds of other electrons and create a chain reaction of broken bonds from one molecule to another. This oxidation reaction can cause mutations in the DNA and rancidity and toxicity in lipids. Antioxidants such as beta carotene, vit. C, bioflavonoids, vit. E, selenium, and glutathione stop this chain reaction.

156. Nutritional Therapies(continued) Foods high in antioxidants (ORAC – oxygen radical absorbance capacity) Prunes 5770 Raisins 2830 Blueberries 2400 Blackberries 2036 Strawberries 1540 Raspberries 1220 Plums 949 Oranges 750 Red Grapes 739 Cherries 670 Kale 1770 Spinach 1260 Brussels Sprouts 1260 Alfalfa Sprouts 930 Broccoli Florets 890 Red Bell Peppers 840 Beets 710 Onions 450

157. Nutritional Therapies(continued) Homocysteine is produced during the incomplete conversion of amino acids to other proteins. Homocysteine is very irritating to artery linings – causing endothelial injury, the oxidation of cholesterol, and the subsequent build up of blood clots and plaque. The low intake of folic acid, vitamin B6 and vitamin B12 can cause homocysteine accumulation.

161. Beans, lentils, chickpeas soybeans

162. Oat bran, barley, wheat germ, rice bran

163. Garlic, raw onion

164. Apples

165. Almonds and walnuts

166. Olive oil, canola oil, grape seed oil

167. Brussels sprouts, parsnips, turnips, okra, artichokes

168. Oranges, apricots, mangos, grapefruit

171. Olive oil as the main dietary fat

172. pineapple – proteases reduce fibrinogen

173. Gingko biloba, green tea, fish oil

174. Vitamin E

176. Reduce or eliminate coffee, smoking, and alcohol

178. Exercise(continued) The test starts by walking on the treadmill at a low speed and elevation. Every 3 minutes, the speed and elevation are increased. The test continues until exhaustion, when you can no longer increase the amount of oxygen to the body.

179. Exercise(continued) Age 20-2930-3940-4950-5960-6970-79 Men 13 12 11 10 9 7 Women 11 10 9 8 7 5 The average man between the age of 20 and 80 years loses 50% of his exercise ability – from 13 minutes to 7 minutes, due to reduce oxygen delivery from atherosclerosis. www.stemcell.md

180. For more information David A Steenblock, BS, MS, DO 26381 Crown Valley Parkway Suite 130 Mission Viejo, CA 800-300-1063 www.stemcell.md