This document provides information on various arboviruses (arthropod-borne viruses transmitted by insects), including their classification, epidemiology, clinical manifestations, diagnosis and treatment. It describes key arboviruses found in India such as chikungunya, Japanese encephalitis and zika viruses. For chikungunya, it outlines the virus structure, transmission cycle, clinical stages, genotypes and laboratory diagnosis. It also provides details on Japanese encephalitis virus transmission patterns, vaccines used for prevention, and yellow fever virus geographical distribution and vaccination.
What is fascioliasis?
In what parts of the world if fascioliasis found?
How do people get infected with fascioliasis?
What are the signs and symptoms of Fasciola infection, and when do they begin?
How is Fasciola infection diagnosed?
Can Fascioliasis be treated?
How can fasciola infection be prevented?
Viruses are microscopic organisms that exist almost everywhere on earth. They can infect animals, plants, fungi, and even bacteria.Viruses vary in complexity. They consist of genetic material, RNA or DNA, surrounded by a coat of protein, lipid (fat), or glycoprotein. Viruses cannot replicate without a host, so they are classified as parasitic.They are considered the most abundant biological entity on the planet.
Here we discuss the general properties of viruses in detail.
What is fascioliasis?
In what parts of the world if fascioliasis found?
How do people get infected with fascioliasis?
What are the signs and symptoms of Fasciola infection, and when do they begin?
How is Fasciola infection diagnosed?
Can Fascioliasis be treated?
How can fasciola infection be prevented?
Viruses are microscopic organisms that exist almost everywhere on earth. They can infect animals, plants, fungi, and even bacteria.Viruses vary in complexity. They consist of genetic material, RNA or DNA, surrounded by a coat of protein, lipid (fat), or glycoprotein. Viruses cannot replicate without a host, so they are classified as parasitic.They are considered the most abundant biological entity on the planet.
Here we discuss the general properties of viruses in detail.
This presentation provides information on the zika virus, includes zika introduction, how Zika is spread, zika symptoms, zika Viral Structure, Diagnosis, Treatment and Prevention.
Japanese encephalites virus [autosaved]KinzaHaroon1
JEV zoonotic disease that infects humans accidentally.
this presentation will briefly discussed virus propertie, it geographic distributions and diagnosis an treatment
Nipah Virus (NiV) is a negative sense, single stranded, enveloped RNA virus.
Zoonotic virus
Family – Paramyxoviridae
Genus - Henipavirus
It is a BSL-4 pathogen.
The name "Nipah" refers to the place, Sungai Nipah (literally 'nipah river') in Malaysia, the source of the human case from which Nipah virus was first isolated.Nipah virus can remain viable for a few days in few fruit juices or mango fruits, and at least 7 days in palm milk.
Bats act as a breeding ground for many dangerous viruses, including Nipah, rabies, and Marburg viruses. Such viruses are not associated with any major pathological changes within the bat population.
Transmission of NiV occurs by eating contaminated food. Risks include contact, touch, breastfeeding, or exposure to an infected person, thereby making it easier to come in contact with a droplet of NiV infection.
More recently, experimental studies with aerosolized NiV in Syrian hamsters have found that NiV droplets (aerosol distribution) may cause NiV transmission during close contact. Drinking fresh palm milk is a very common method, and the use of Tari (ripe palm juice) is a powerful way to transmit the virus.
The views expressed in the presentations are that of the author and do not necessarily reflect the views of the Government of Canada. Presentations are shared in the original format received from the presenter.
Presentations given at the Conference to Develop a Federal Framework on Lyme Disease are the property of the author, unless otherwise cited. If you reference the author's work, you must give the author credit by naming the author and their work as well as the place and date it was presented.
For more information, contact the Lyme Disease Conference Secretariat at maladie_lyme_disease@phac-aspc.gc.ca
Chickengunia in pregnancy by dr alka & dr apurva mukherjee nagpur m.s. indiaalka mukherjee
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This Gasta posits a strategic approach to integrating AI into HEIs to prepare staff, students and the curriculum for an evolving world and workplace. We will highlight the advantages of working with these technologies beyond the realm of teaching, learning and assessment by considering prompt engineering skills, industry impact, curriculum changes, and the need for staff upskilling. In contrast, not engaging strategically with Generative AI poses risks, including falling behind peers, missed opportunities and failing to ensure our graduates remain employable. The rapid evolution of AI technologies necessitates a proactive and strategic approach if we are to remain relevant.
How to Make a Field invisible in Odoo 17Celine George
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Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
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2. Objectives
After studying this section students should be able to
1) Define arboviruses.
2) Classify arboviruses.
3) Describe chikungunya virus.
4) Describe Japanese encephalitis virus.
5) Describe zika virus.
6) Describe yellow virus.
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3. What is arbovirus ?
• Arthropod borne viruses.
• RNA viruses
• Transmitted by blood sucking insects from one vertebrate host to
other.
• Multiply inside the insect to establish harmless infection.
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10. Fever arthralgia group
• Chikungunya fever – characterized by fever with arthralgia.
• Name derived from Makonde word kungunyala meaning bends up.
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20. Japanese encephalitis
• Japanese B encephalitis is the leading cause of viral encephalitis in
Asia, including India.
• History
JE virus was so named because the disease
was first seen in Japan ( 1871) as "Summer
encephalitis epidemics .
But now uncommon in Japan (A ).
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21. Epidemiology
• Vector: Culex mosquito
Common vector found in India
C. tritaneniorhynchus
C. Vishnui
• Transmission cycle:
Infects non human hosts animals and birds.
Two transmission cycles are predominant.
• Pigs - Culex - Pigs
• Ardeid birds- Culex- Ardeid bird
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22. Epidemiology
• Host
Pigs – Amplifier host.
Humans are considered as dead end
Bird hosts: herons, ducks .
• Age: 85% of cases occur in children
below 15 years and 10% occur in elderly.
• Seasonal variation: common in rainy season which coincides with
maximum mosquito activity.
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23. Clinical Manifestations
• Incubation period - from 5- 15 days.
• Subclinical infection is common.
• Clinical course - divided into three stages:
1. Prodromal stage is a febrile illness.
2. Acute encephalitis stage:
convulsions, behavioral changes,
meningeal signs or paralysis.
3. Late stage and sequelae: convalescent stage
may be recovered fully or retain some neurological deficits permanently.
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24. Lab diagnosis
• IgM capture antibody ELISA – uses JERA JE recombinant antigen to
detect IgM ab.
• RT PCR. To detect envelope
E gene.
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25. Vaccine Prophylaxis for Japanese Encephalitis
• Live attenuated SA 14-14-2 vaccine:
• It is prepared from SA 14-14-2 strain of JE virus .
• It is cell line derived; primary hamster kidney cells are commonly used.
• Single dose - subcutaneously, followed by booster dose after 1 year.
• It is manufactured in China, but now licensed in India.
• Inactivated vaccine (Nakayama strain and Beijing strain)
• Both are mouse brain derived and formalin inactivated.
• Prepared in Central Research Institute, Kasauli (India) .
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26. • Inactivated vaccine (Beijing P3 strain): It is a cell line derived
vaccine.
• Combined vaccine – genetically engineered.
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27. Zika virus
• Zika fever: a febrile or sub-febrile illness caused by ZIKV , 2015- 16.
• Flaviviridae ( DENV, WNV, YF,JE)
• Aedes mosquitoes
• reservoir - rhesus monkey from the Zika Forest in Uganda in 1947
• ss RNA ,Genome sequenced in 2006
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28. ZIKA VIRUS - Flavivirus family
•The genome is a ~10.8 kilobase, positive
strand RNA enclosed in a capsid and surrounded
by a membrane .
•The envelope (E) glycoprotein allows attachment
of the virus particle to the host cell receptor to
initiate infection.
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29. Clinical manifestation
• About 1 in 5 people infected with
Zika virus become ill .
• Fever, rash, joint pain, or conjunctivitis.
• Others are myalgia and head ache .
• Incubation period - few days to a week.
• The illness is usually mild with symptoms lasting for several days to a
week.
• Zika virus usually remains in the blood of an infected person for
about a week but it can be found longer in some people.
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30. Risk of Zika during pregnancy
• According to pediatric neurologists in Brazil that some pregnant
women infected by zika virus have given birth to the babies with a
birth defect called microcephaly.
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31. Transmission
• Through mosquito bites:
• Zika virus is transmitted - Aedes species mosquito (A. aegypti and A.
albopictus).
•
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32. From mother to child
• A mother can pass on the virus to her newborn around the time of
birth.
• It is possible that Zika virus could be passed from a mother to her
baby during pregnancy.
• No reports of infants - through breastfeeding.
• Mothers are encouraged to breastfeed - where Zika virus is found.
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33. Through sexual contact
• Zika virus is transmitted to the people through sexual activity.
• (CDC) of the first Zika virus case acquired through sexual
transmission in Dallas County in 2016.
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34. Diagnosis
• RT PCR – RNA in urine (upto 7 d) and blood (upto 5 d).
• IgM ab detection.
Vaccines are under trial.
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35. Yellow Fever Virus
• Yellow fever - acute, febrile illness.
• Severe cases - liver dysfunction which leads to jaundice (hence the
name yellow fever), renal dysfunction and hemorrhage, high
mortality.
• Geographical distribution: endemic in West Africa and Central South
America.
• Typing: Seven genotypes, five in Africa and two in South America.
Only one serotype is known to exist.
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36. Transmission and Clinical Manifestations
• Vector: Humans - bite of Aedes aegypti.
Incubation period is - 3-6 days.
• Presence of fever, chills, headache, myalgia,
and backache-followed by nausea, vomiting,
and relative bradycardia.
• Viremic - source of infection for mosquitoes.
.
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37. Severe cases are characterized by
• Hemorrhagic manifestations
• Platelet dysfunction
• Features of liver involvemenl (hepatitis) are:
Mid-zonal necrosis and presence of counicilman bodies.
lntranuclear inclusions - hepatocytes called Torres bodies.
Appearance of jaundice.
• Renal dysfunction
• Encephalitis occurs very rarely.
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38. Yellow Fever 17 D Vaccine
• Live attenuated vaccine, prepared in allantoic cavity of chick embryo.
• No risk of encephalitis ( previously used mouse brain derived
inactivated Dakar vaccine - encephalitogenic).
• In India: Central Research Institute (CRI), Kasauli.
Available in lyophilized form and has to be
reconstituted before use.
• Dosage: Single dose, given subcutaneously.
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39. • Certificate is issued .
• Cholera and yellow fever vaccine interact with each other, hence
should not be given together (3 weeks gap to be maintained).
• Contraindications :
• Children < 9 months,
Pregnancy (except during outbreak)
HIV infected people .
People with allergy to egg.
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40. Questions ???????
REFRENCES
• Wikipedia
• Anonymous: Yellow fever outbreaks in the Americas. Disasters: Preparedness and Mitigation in
the Americas. March issue, 109,4 (2008).
• PAHO: Update on jungle Yellow fever (JYF) in Brazil, Paraguay, and Argentina. PAHO Press
Release. 11 February (2008).
• PAHO: Mobilization against yellow fever in Paraguay continues. PAHO Press Release. 26 February
(2008).
• Pastorino B, Muyembe-Tamfum JJ, Bessaud M et al.: Epidemic resurgence of chikungunya virus in
democratic Republic of the Congo: identification of a new central African strain. J. Med.
Virol. 74,277–282 (2004).
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