The document discusses different application architectures:
1. 2-Tier Architecture with clients directly connecting to a database.
2. 3-Tier Architecture separates the user interface, business logic, and data layers. A common example is a web application with a browser, web server, and database.
3. The latest paradigm separates the presentation layer (HTML/JavaScript) from the business logic/data layers, which communicate via APIs, XML, JSON, or custom messaging. Each page loads and requests data from the API layer using Ajax. This provides a more modular architecture.