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The Continuous Update Project: Introduction
to the Project
22 November 2015
Martin Wiseman
World Cancer Research Fund International & University
of Southampton
Who we are What we do
Fund research on the relationship of nutrition,
physical activity and body weight to cancer
risk
Interpret the accumulated scientific literature to
derive Recommendations for Cancer
Prevention
Educate people through our national Health
Information programmes
Advocate effective policies to help people and
populations to reduce their chances of
developing cancer
AICR
WCRF UK
WCRF Netherlands
WCRF HK
WCRF International
1. New method
2. Systematic reviews
3. Review of evidence separate from
judgement
4. Panel of international experts
5. Predetermined criteria for judgements
Epidemiology
Mechanisms
6. Flexibility
7. Continuous update of evidence
WCRF/AICR EXPERT REPORT
The most authoritative
NUTRITION AND CANCERS
• OBESITY
– BREAST (PM), COLORECTUM, ENDOMETRIUM, OESOPHAGUS,
PANCREAS, GALLBLADDER, KIDNEY, LIVER, OVARY, ADVANCED
PROSTATE
• PHYSICAL ACTIVITY
– COLON, BREAST, ENDOMETRIUM
• MEAT – RED AND PROCESSED
– COLORECTAL
• ALCOHOL
– MPL, BREAST, COLORECTUM, LIVER
• FRUIT AND VEGETABLES
– MPL, OESOPHAGUS, STOMACH, COLORECTAL (DF), LUNG
• BREASTFEEDING
– BREAST (MOTHER), OBESITY (CHILD)
The Panel emphasises the
importance of not smoking and of
avoiding exposure to tobacco smoke
The Continuous Update Project.
Aims
Ensure everyone has access
Based on the most up to date scientific evidence
WCRF/AICR Recommendations for Cancer Prevention:
• Keep evidence, conclusions and
recommendations updated into the future
• Working with team at ICL
• Same principles:
- Systematically review evidence
- Meta analysis
- Panel of experts
-draw conclusions
-make recommendations
Continuous Update Project
(CUP)
What is the
Continuous Update Project?
Continuous update epidemiologic evidence
(SLR- Imperial College London)
Up-to-date database
Mechanistic evidence
(University of Bristol)
Evaluation of evidence
(Independent panel of experts)
Recommendations
Education, policy and research priorities
The Continuous Update
Process
Continuous update epidemiologic evidence
(SLR- Imperial College London)
CUP Search Literature Review PROTOCOL
(SLR- Imperial College London)
Research topic :
The associations between food, nutrition and physical activity and
 Cancer risk
 Mortality and second cancers in breast cancer survivors.
Main objective :
Summarize the evidence from prospective studies and randomised
controlled trials (case-control studies if requested by the Panel).
Search strategy:
Medline, Central, ClinialTrials.gov
Hand search of references (reviews, meta-analysis, recent relevant
papers)
http://www.wcrf.org/int/research-we-fund/continuous-update-project-cup/cancer-survivors-protocol-committee
One central database for cancer
prevention research
Team
Database
CUP Expert Panel
WCRF Secretariat
Statistical methods
Dose-response meta-analysis using generalized least-squares for trend estimation
(command GLST in Stata)
Statistical methods
Publication bias Exploratory analyses
Statistical methods
Stratified analyses, sensitivity analyses
• Until 2016 - Rolling programme of updates
- Cancer by cancer
• 2016-2017 – Panel review evidence for all
cancers
• 2017 – Statement to be published on evidence
• From 2017 – continue to update and review
evidence
Plan of work
Year Publications
2010 Breast
2011 Colorectum
2012 Pancreas
2013 Endometrium
2014 Ovary, prostate and breast cancer
survivors
2015 Liver, kidney, gallbladder, bladder
2015-2016 Stomach, oesophagus, lung
2016-2017 Breast, colorectum
2017 Major report – Recommendations
Timeline
CUP database
CUP report downloads
Total downloads: 4273 vs. 806
Journal articles
0
2
4
6
8
Colorectum Pancreas Breast Prostate
8
3 3
1
Numberofarticles
Cancer of
16 published
Includes articles published by ICL (13), WCRF (1), UEA (1) + breast cancer
survivors
The Continuous Update Project
Expert Panel
www.wcrf.org/int/research-we-fund/continuous-update-project-cup

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AORTIC Conference - The Continuous Update Project: Introduction to the Project

  • 1. The Continuous Update Project: Introduction to the Project 22 November 2015 Martin Wiseman World Cancer Research Fund International & University of Southampton
  • 2. Who we are What we do Fund research on the relationship of nutrition, physical activity and body weight to cancer risk Interpret the accumulated scientific literature to derive Recommendations for Cancer Prevention Educate people through our national Health Information programmes Advocate effective policies to help people and populations to reduce their chances of developing cancer AICR WCRF UK WCRF Netherlands WCRF HK WCRF International
  • 3. 1. New method 2. Systematic reviews 3. Review of evidence separate from judgement 4. Panel of international experts 5. Predetermined criteria for judgements Epidemiology Mechanisms 6. Flexibility 7. Continuous update of evidence WCRF/AICR EXPERT REPORT The most authoritative
  • 4. NUTRITION AND CANCERS • OBESITY – BREAST (PM), COLORECTUM, ENDOMETRIUM, OESOPHAGUS, PANCREAS, GALLBLADDER, KIDNEY, LIVER, OVARY, ADVANCED PROSTATE • PHYSICAL ACTIVITY – COLON, BREAST, ENDOMETRIUM • MEAT – RED AND PROCESSED – COLORECTAL • ALCOHOL – MPL, BREAST, COLORECTUM, LIVER • FRUIT AND VEGETABLES – MPL, OESOPHAGUS, STOMACH, COLORECTAL (DF), LUNG • BREASTFEEDING – BREAST (MOTHER), OBESITY (CHILD)
  • 5. The Panel emphasises the importance of not smoking and of avoiding exposure to tobacco smoke
  • 6. The Continuous Update Project. Aims Ensure everyone has access Based on the most up to date scientific evidence WCRF/AICR Recommendations for Cancer Prevention:
  • 7. • Keep evidence, conclusions and recommendations updated into the future • Working with team at ICL • Same principles: - Systematically review evidence - Meta analysis - Panel of experts -draw conclusions -make recommendations Continuous Update Project (CUP)
  • 8. What is the Continuous Update Project? Continuous update epidemiologic evidence (SLR- Imperial College London) Up-to-date database Mechanistic evidence (University of Bristol) Evaluation of evidence (Independent panel of experts) Recommendations Education, policy and research priorities
  • 10. Continuous update epidemiologic evidence (SLR- Imperial College London)
  • 11. CUP Search Literature Review PROTOCOL (SLR- Imperial College London) Research topic : The associations between food, nutrition and physical activity and  Cancer risk  Mortality and second cancers in breast cancer survivors. Main objective : Summarize the evidence from prospective studies and randomised controlled trials (case-control studies if requested by the Panel). Search strategy: Medline, Central, ClinialTrials.gov Hand search of references (reviews, meta-analysis, recent relevant papers) http://www.wcrf.org/int/research-we-fund/continuous-update-project-cup/cancer-survivors-protocol-committee
  • 12. One central database for cancer prevention research Team Database CUP Expert Panel WCRF Secretariat
  • 13.
  • 14. Statistical methods Dose-response meta-analysis using generalized least-squares for trend estimation (command GLST in Stata)
  • 15. Statistical methods Publication bias Exploratory analyses
  • 17. • Until 2016 - Rolling programme of updates - Cancer by cancer • 2016-2017 – Panel review evidence for all cancers • 2017 – Statement to be published on evidence • From 2017 – continue to update and review evidence Plan of work
  • 18. Year Publications 2010 Breast 2011 Colorectum 2012 Pancreas 2013 Endometrium 2014 Ovary, prostate and breast cancer survivors 2015 Liver, kidney, gallbladder, bladder 2015-2016 Stomach, oesophagus, lung 2016-2017 Breast, colorectum 2017 Major report – Recommendations Timeline
  • 20. CUP report downloads Total downloads: 4273 vs. 806
  • 21. Journal articles 0 2 4 6 8 Colorectum Pancreas Breast Prostate 8 3 3 1 Numberofarticles Cancer of 16 published Includes articles published by ICL (13), WCRF (1), UEA (1) + breast cancer survivors
  • 22.
  • 23. The Continuous Update Project Expert Panel