Introduction to the WCRF International Continuous Update Project
By Dr Rachel Thompson, Head of Research Interpretation/ Head CUP Secretariat
6 December 2014, UICC World Cancer Congress, Melbourne
Professor Martin Wiseman presentation on The Continuous Update Project: Introduction to the Project at FENS European Nutrition Conference, 20-23 October 2015 Berlin (Germany).
The 20th International Congress of Nutrition (ICN) hosted by the International Union of Nutritional Science (IUNS) took place on the 15th-20th September 2013, Granada, Spain. WCRF International held a 2-hour symposium on the Continuous Update Project (CUP) entitled ‘Food, Nutrition, Physical Activity and Cancer – Keeping the Evidence Current: WCRF/AICR Continuous Update Project (CUP).’ It included four presentations exploring the latest updates from the CUP.
Professor Martin Wiseman’s presentation, The Continuous Update Project: Introduction to the Project, at the African Organisation for Research & Training in Cancer (AORTIC) conference, 18-22 November 2015, Marrakech, Morocco.
Corinna Hawkes presented on policies available to improve diets and maximize their impact. There are over 200 implemented policies across 75 countries in areas like nutrition education in schools, fruit programs, trans fat bans, and taxes on unhealthy foods. Effective policies provide environments for healthy learning, overcome barriers to healthy choices, and encourage re-evaluating unhealthy preferences. To maximize impact, policies should be tailored to problems and populations, comprehensive rather than isolated, and mutually reinforcing as a package.
WCRF International Continuous Update Project (CUP). Presentation given by Giota Mitrou PhD MSc, Head of Research Funding and Science Activities, World Cancer Research Fund International (WCRF International).
What is the current evidence between alcohol and cancer?
Presentation given by Giota Mitrou PhD MSc, Head of Research Funding and Science Activities, World Cancer Research Fund International (WCRF International).
Professor Martin Wiseman presentation on The Continuous Update Project: Introduction to the Project at FENS European Nutrition Conference, 20-23 October 2015 Berlin (Germany).
The 20th International Congress of Nutrition (ICN) hosted by the International Union of Nutritional Science (IUNS) took place on the 15th-20th September 2013, Granada, Spain. WCRF International held a 2-hour symposium on the Continuous Update Project (CUP) entitled ‘Food, Nutrition, Physical Activity and Cancer – Keeping the Evidence Current: WCRF/AICR Continuous Update Project (CUP).’ It included four presentations exploring the latest updates from the CUP.
Professor Martin Wiseman’s presentation, The Continuous Update Project: Introduction to the Project, at the African Organisation for Research & Training in Cancer (AORTIC) conference, 18-22 November 2015, Marrakech, Morocco.
Corinna Hawkes presented on policies available to improve diets and maximize their impact. There are over 200 implemented policies across 75 countries in areas like nutrition education in schools, fruit programs, trans fat bans, and taxes on unhealthy foods. Effective policies provide environments for healthy learning, overcome barriers to healthy choices, and encourage re-evaluating unhealthy preferences. To maximize impact, policies should be tailored to problems and populations, comprehensive rather than isolated, and mutually reinforcing as a package.
WCRF International Continuous Update Project (CUP). Presentation given by Giota Mitrou PhD MSc, Head of Research Funding and Science Activities, World Cancer Research Fund International (WCRF International).
What is the current evidence between alcohol and cancer?
Presentation given by Giota Mitrou PhD MSc, Head of Research Funding and Science Activities, World Cancer Research Fund International (WCRF International).
The document summarizes trials methodology research conducted at the University of Birmingham by the MRC Midland Hub for Trials Methodology Research led by Professor Lucinda Billingham. It outlines the hub's research themes, projects, highlights and future plans. The hub's mission is to be a center of excellence for trials methodology research to improve trial design, conduct, analysis and reporting and ultimately patient care. It has funded methodological research projects, training programs and an advisory service. Notable projects include work on patient-reported outcomes, stratified medicine, early phase trials and novel trial designs. Funding for the hub will cease in May 2014 but the research team aims to continue as a center of excellence for trials methodology within the Birmingham Centre
This document presents a personalized prevention strategy for cervical cancer based on risk stratification using genetic and epigenetic markers. It finds that combining HPV vaccination with triennial Pap smear screening would be cost-effective, especially if vaccination costs decrease. Genetic and methylation biomarkers can stratify women into different risk levels. For low to medium risk women, triennial Pap smears alone can reduce cervical cancer incidence by 55-65%. However, HPV vaccination plus Pap smears is necessary for high risk women. Screening strategies and intervals should be personalized based on a woman's genetic risk score.
The document is a guidebook for using the Malnutrition Universal Screening Tool (MUST) to screen adults for malnutrition risk. It estimates that over 3 million people in the UK are at risk of malnutrition based on nutrition screening week surveys that found 28-42% of hospital and care home patients to be at medium or high risk. Malnutrition has significant health, social care, and economic costs due to consequences like impaired immune function and wound healing, reduced muscle strength, and increased risk of falls and hospital admissions. The MUST tool and guidebook aim to improve malnutrition screening and care planning.
This document discusses malnutrition screening using the Malnutrition Universal Screening Tool (MUST) in various healthcare settings in the UK. It reports that malnutrition affects over 3 million people in the UK, with most cases occurring in the community rather than hospitals. MUST screening data has found malnutrition risk prevalence of approximately 28% in UK hospitals, 16-21% in outpatient clinics, 10-12% in sheltered housing, 30-42% in care homes, and an estimated 4.8% in GP surgeries. The document also discusses associations between malnutrition risk and deprivation as well as healthcare outcomes and costs.
The impact of National Bowel Cancer Screening Program in AustraliaCancer Institute NSW
The full rollout of the National Bowel Cancer Screening Program (NBCSP), offering free biennial screening using immunochemical Fecal Occult Blood Test (iFOBT) for 50-74 years is targeted for 2020. In 2013-14, the overall participation rate among Australians who were invited to participate was 36%.
This document summarizes a study on cervical cancer screening among women ages 25-64 in urban areas of Indonesia. The study found a prevalence of precancerous cervical lesions of 7.0% among over 36,000 women screened using visual inspection with acetic acid. This rate is higher than findings from a previous study in Jakarta that found a 4.21% positive rate. The document also notes that cervical cancer is a major public health issue and leading cause of cancer death for women in developing countries. It aims to assess the prevalence of precancerous lesions and cervical cancer screening practices in Indonesia.
Mapping lung cancer diagnostic pathways: a qualitative study of interviews wi...Cancer Institute NSW
Lung cancer remains the leading cause of cancer death in developed countries. There is growing evidence that earlier diagnosis of lung cancer is an important factor in improving outcomes. Despite this, there is surprisingly little qualitative research that documents lung cancer patients' diagnostic pathway and beyond.
Optimising the Model of Care for Patient Management at The Tweed Cancer Care ...Cancer Institute NSW
The document describes the implementation of a morning handover process utilizing the MOSAIQ electronic medical record (EMR) system at the Tweed Cancer Care and Haematology Unit. An evaluation found the EMR handover process improved staff satisfaction, coordination of patient care, and reduced incidents. It was concluded the handover process meets national standards and could benefit other ambulatory care units utilizing EMRs.
Addressing severe-acute malnutrition in Rajasthan using community-based strat...POSHAN
This presentation was made by Dr. Deepti Gulati (GAIN) in the session on ‘Implementation research on delivery of preventive and curative interventions during early childhood’ at the POSHAN Conference "Delivering for Nutrition in India Learnings from Implementation Research", November 9–10, 2016, New Delhi.
For more information about the conference visit our website: www.poshan.ifpri.info
Do EQ-5D-3L and EQ-5D-5L Capture the Same Changes in Quality of Life Over Tim...Office of Health Economics
Slides from a presentation given by OHE's Patricia Cubi-Molla and Paula Lorgelly on a EQ-5D-3L and EQ-5D-5L longitudinal study of cancer patients: do they capture the same changes in quality of life over time?
This study examined the association between overweight/obesity and breast cancer in India. The study found that breast cancer patients had higher average weight, BMI, and mid-upper arm circumference compared to controls. Obesity was positively associated with increased breast cancer risk, with higher BMI groups facing greater odds of breast cancer. Maintaining a healthy weight may be a modifiable way to reduce breast cancer risk and impact women's health in India. However, the study had limitations such as insufficient demographic profiling and lack of perfect matching between cases and controls.
This document summarizes a literature review on outcomes that matter in cancer. It finds that while clinical outcomes are important, patient-reported outcomes (PROs) and experiences (PREs) also need to be considered to fully capture the impact and value of cancer treatments. The review identified many potential outcome domains from the literature, including survival, symptoms, physical/cognitive/emotional functioning, and social/quality of life impacts. Further qualitative research is planned to better understand which outcomes are most important to patients and how outcomes could be linked to the price of new cancer drugs.
Community-based management of severe acute malnutrition in India: New evidenc...POSHAN
This presentation was made by Dr. Alan Pereira (Medicins Sans Frontiers) in the session on ‘Implementation research on delivery of preventive and curative interventions during early childhood’ at the POSHAN Conference "Delivering for Nutrition in India Learnings from Implementation Research", November 9–10, 2016, New Delhi.
For more information about the conference visit our website: www.poshan.ifpri.info
5th Annual Early Age Onset Colorectal Cancer Summit - Session II: Family History Ascertainment in the US - What Steps are Needed to Improve the Well Documented Less Than Optimal Status of this Situation?
Predictors of MDT review and the impact on lung cancer survival for HNELHD re...Cancer Institute NSW
Review by a Multidisciplinary Team (MDT) has been shown to lead to increased rates of surgical resection, radiotherapy, chemotherapy and timeliness of care. Most recently, the Victorian lung cancer patterns of care study have found that MDT review is an independent predictor of lung cancer survival.
Identifying individuals at high risk for lung cancer in AustraliaSax Institute
This document summarizes research evaluating a risk prediction tool called PLCOm2012 for identifying high-risk individuals for lung cancer screening in Australia. The tool was validated using data from the 45 and Up Study, an ongoing cohort study of over 260,000 Australians aged 45 and older. Results showed PLCOm2012 predicted lung cancer incidence well and identified more high-risk individuals than the criteria used in the National Lung Screening Trial. Further modeling is still needed to fully assess the effectiveness and cost-effectiveness of using PLCOm2012 to target lung cancer screening in Australia.
The document discusses cancer prevention efforts in Malaysia. It provides information on the National Cancer Registry and reports cancer incidence data from 2007-2011. The top three most common cancers in Malaysia are breast, colorectal, and lung cancer. It also outlines the National Strategic Plan for Cancer Control Programme from 2016-2020, which aims to reduce the impact of cancer through various prevention and early detection efforts, including screening programs. Current cancer screening approaches in Malaysia are more opportunistic than organized at the population level.
1 sample16c56 introduction-to-epidemiologyMary Jones
This document summarizes a study that examined the relationship between coffee and tea consumption and the incidence of endometrial cancer. The study used a hospital-based case-control design, collecting data from 541 women diagnosed with endometrial cancer and 541 women without the cancer. The primary explanatory variables were consumption of normal coffee, decaffeinated coffee, and tea. Other potential confounding factors considered included age, BMI, education level, menopausal status, hormone therapy use, oral contraceptive use, pregnancy history, and smoking status. The study aimed to determine if coffee and tea consumption had any causal relationship to the occurrence of endometrial cancer.
This document summarizes oral cancer statistics and research in Thailand. It finds that oral cancer is a leading cancer, with betel quid chewing and smoking as major risk factors. A study in Northeast Thailand found a prevalence of 3.8% for oral pre-malignant lesions. Another study compared oral cancer survival rates before and after Thailand implemented universal health coverage in 2002, finding improved survival rates post-implementation. Current challenges include expanding population-based screening programs, improving cancer treatment outcomes, and focusing on patients' quality of life.
This document discusses different types of study designs used in nutrition research and their relative strengths and limitations. It covers randomized controlled trials, systematic reviews, meta-analyses, and various types of observational studies including cross-sectional, case-control, and cohort studies. It emphasizes that randomized controlled trials are considered the gold standard but that many nutrition questions cannot be answered through these designs. It also discusses important concepts like confounding, biases, reporting guidelines, and how to assess the quality and strengths of different nutrition studies.
The document summarizes trials methodology research conducted at the University of Birmingham by the MRC Midland Hub for Trials Methodology Research led by Professor Lucinda Billingham. It outlines the hub's research themes, projects, highlights and future plans. The hub's mission is to be a center of excellence for trials methodology research to improve trial design, conduct, analysis and reporting and ultimately patient care. It has funded methodological research projects, training programs and an advisory service. Notable projects include work on patient-reported outcomes, stratified medicine, early phase trials and novel trial designs. Funding for the hub will cease in May 2014 but the research team aims to continue as a center of excellence for trials methodology within the Birmingham Centre
This document presents a personalized prevention strategy for cervical cancer based on risk stratification using genetic and epigenetic markers. It finds that combining HPV vaccination with triennial Pap smear screening would be cost-effective, especially if vaccination costs decrease. Genetic and methylation biomarkers can stratify women into different risk levels. For low to medium risk women, triennial Pap smears alone can reduce cervical cancer incidence by 55-65%. However, HPV vaccination plus Pap smears is necessary for high risk women. Screening strategies and intervals should be personalized based on a woman's genetic risk score.
The document is a guidebook for using the Malnutrition Universal Screening Tool (MUST) to screen adults for malnutrition risk. It estimates that over 3 million people in the UK are at risk of malnutrition based on nutrition screening week surveys that found 28-42% of hospital and care home patients to be at medium or high risk. Malnutrition has significant health, social care, and economic costs due to consequences like impaired immune function and wound healing, reduced muscle strength, and increased risk of falls and hospital admissions. The MUST tool and guidebook aim to improve malnutrition screening and care planning.
This document discusses malnutrition screening using the Malnutrition Universal Screening Tool (MUST) in various healthcare settings in the UK. It reports that malnutrition affects over 3 million people in the UK, with most cases occurring in the community rather than hospitals. MUST screening data has found malnutrition risk prevalence of approximately 28% in UK hospitals, 16-21% in outpatient clinics, 10-12% in sheltered housing, 30-42% in care homes, and an estimated 4.8% in GP surgeries. The document also discusses associations between malnutrition risk and deprivation as well as healthcare outcomes and costs.
The impact of National Bowel Cancer Screening Program in AustraliaCancer Institute NSW
The full rollout of the National Bowel Cancer Screening Program (NBCSP), offering free biennial screening using immunochemical Fecal Occult Blood Test (iFOBT) for 50-74 years is targeted for 2020. In 2013-14, the overall participation rate among Australians who were invited to participate was 36%.
This document summarizes a study on cervical cancer screening among women ages 25-64 in urban areas of Indonesia. The study found a prevalence of precancerous cervical lesions of 7.0% among over 36,000 women screened using visual inspection with acetic acid. This rate is higher than findings from a previous study in Jakarta that found a 4.21% positive rate. The document also notes that cervical cancer is a major public health issue and leading cause of cancer death for women in developing countries. It aims to assess the prevalence of precancerous lesions and cervical cancer screening practices in Indonesia.
Mapping lung cancer diagnostic pathways: a qualitative study of interviews wi...Cancer Institute NSW
Lung cancer remains the leading cause of cancer death in developed countries. There is growing evidence that earlier diagnosis of lung cancer is an important factor in improving outcomes. Despite this, there is surprisingly little qualitative research that documents lung cancer patients' diagnostic pathway and beyond.
Optimising the Model of Care for Patient Management at The Tweed Cancer Care ...Cancer Institute NSW
The document describes the implementation of a morning handover process utilizing the MOSAIQ electronic medical record (EMR) system at the Tweed Cancer Care and Haematology Unit. An evaluation found the EMR handover process improved staff satisfaction, coordination of patient care, and reduced incidents. It was concluded the handover process meets national standards and could benefit other ambulatory care units utilizing EMRs.
Addressing severe-acute malnutrition in Rajasthan using community-based strat...POSHAN
This presentation was made by Dr. Deepti Gulati (GAIN) in the session on ‘Implementation research on delivery of preventive and curative interventions during early childhood’ at the POSHAN Conference "Delivering for Nutrition in India Learnings from Implementation Research", November 9–10, 2016, New Delhi.
For more information about the conference visit our website: www.poshan.ifpri.info
Do EQ-5D-3L and EQ-5D-5L Capture the Same Changes in Quality of Life Over Tim...Office of Health Economics
Slides from a presentation given by OHE's Patricia Cubi-Molla and Paula Lorgelly on a EQ-5D-3L and EQ-5D-5L longitudinal study of cancer patients: do they capture the same changes in quality of life over time?
This study examined the association between overweight/obesity and breast cancer in India. The study found that breast cancer patients had higher average weight, BMI, and mid-upper arm circumference compared to controls. Obesity was positively associated with increased breast cancer risk, with higher BMI groups facing greater odds of breast cancer. Maintaining a healthy weight may be a modifiable way to reduce breast cancer risk and impact women's health in India. However, the study had limitations such as insufficient demographic profiling and lack of perfect matching between cases and controls.
This document summarizes a literature review on outcomes that matter in cancer. It finds that while clinical outcomes are important, patient-reported outcomes (PROs) and experiences (PREs) also need to be considered to fully capture the impact and value of cancer treatments. The review identified many potential outcome domains from the literature, including survival, symptoms, physical/cognitive/emotional functioning, and social/quality of life impacts. Further qualitative research is planned to better understand which outcomes are most important to patients and how outcomes could be linked to the price of new cancer drugs.
Community-based management of severe acute malnutrition in India: New evidenc...POSHAN
This presentation was made by Dr. Alan Pereira (Medicins Sans Frontiers) in the session on ‘Implementation research on delivery of preventive and curative interventions during early childhood’ at the POSHAN Conference "Delivering for Nutrition in India Learnings from Implementation Research", November 9–10, 2016, New Delhi.
For more information about the conference visit our website: www.poshan.ifpri.info
5th Annual Early Age Onset Colorectal Cancer Summit - Session II: Family History Ascertainment in the US - What Steps are Needed to Improve the Well Documented Less Than Optimal Status of this Situation?
Predictors of MDT review and the impact on lung cancer survival for HNELHD re...Cancer Institute NSW
Review by a Multidisciplinary Team (MDT) has been shown to lead to increased rates of surgical resection, radiotherapy, chemotherapy and timeliness of care. Most recently, the Victorian lung cancer patterns of care study have found that MDT review is an independent predictor of lung cancer survival.
Identifying individuals at high risk for lung cancer in AustraliaSax Institute
This document summarizes research evaluating a risk prediction tool called PLCOm2012 for identifying high-risk individuals for lung cancer screening in Australia. The tool was validated using data from the 45 and Up Study, an ongoing cohort study of over 260,000 Australians aged 45 and older. Results showed PLCOm2012 predicted lung cancer incidence well and identified more high-risk individuals than the criteria used in the National Lung Screening Trial. Further modeling is still needed to fully assess the effectiveness and cost-effectiveness of using PLCOm2012 to target lung cancer screening in Australia.
The document discusses cancer prevention efforts in Malaysia. It provides information on the National Cancer Registry and reports cancer incidence data from 2007-2011. The top three most common cancers in Malaysia are breast, colorectal, and lung cancer. It also outlines the National Strategic Plan for Cancer Control Programme from 2016-2020, which aims to reduce the impact of cancer through various prevention and early detection efforts, including screening programs. Current cancer screening approaches in Malaysia are more opportunistic than organized at the population level.
1 sample16c56 introduction-to-epidemiologyMary Jones
This document summarizes a study that examined the relationship between coffee and tea consumption and the incidence of endometrial cancer. The study used a hospital-based case-control design, collecting data from 541 women diagnosed with endometrial cancer and 541 women without the cancer. The primary explanatory variables were consumption of normal coffee, decaffeinated coffee, and tea. Other potential confounding factors considered included age, BMI, education level, menopausal status, hormone therapy use, oral contraceptive use, pregnancy history, and smoking status. The study aimed to determine if coffee and tea consumption had any causal relationship to the occurrence of endometrial cancer.
This document summarizes oral cancer statistics and research in Thailand. It finds that oral cancer is a leading cancer, with betel quid chewing and smoking as major risk factors. A study in Northeast Thailand found a prevalence of 3.8% for oral pre-malignant lesions. Another study compared oral cancer survival rates before and after Thailand implemented universal health coverage in 2002, finding improved survival rates post-implementation. Current challenges include expanding population-based screening programs, improving cancer treatment outcomes, and focusing on patients' quality of life.
This document discusses different types of study designs used in nutrition research and their relative strengths and limitations. It covers randomized controlled trials, systematic reviews, meta-analyses, and various types of observational studies including cross-sectional, case-control, and cohort studies. It emphasizes that randomized controlled trials are considered the gold standard but that many nutrition questions cannot be answered through these designs. It also discusses important concepts like confounding, biases, reporting guidelines, and how to assess the quality and strengths of different nutrition studies.
Family Planning for Persons Living with HIVAIDS_2015 AR and MSNikole Gettings
This document provides information about reproductive choices and family planning for people living with HIV/AIDS. It outlines the objectives of presenting on this topic, which are to discuss reproductive life needs and planning, effective contraception options and drug interactions, pregnancy options and counseling, and local resources. It then provides statistics on HIV and discusses developing a reproductive life plan, categorizing and discussing various contraception methods, and special considerations for contraception and HIV.
This document describes the Continuous Update Project, a novel approach developed by the World Cancer Research Fund to systematically review mechanistic evidence on diet, nutrition, physical activity and cancer. The approach involves conducting systematic reviews and meta-analyses of both epidemiological and mechanistic studies to make judgements on causal relationships. It emphasizes reproducibility, predefined criteria, and reviews evidence separately from making judgements. The goal is to help identify causal links between exposures and cancer outcomes.
Assignment 2 Final Project Part III Designing a StudyYou are t.docxrock73
Assignment 2: Final Project Part III: Designing a Study
You are the hospital administrator in a medium-sized, urban, for-profit hospital that caters to middle-income groups. You wonder if patients' satisfaction with the hospital stay will increase significantly if they are given better and more flexible meal options. You decide to conduct a research study to find the answer. The first step is to design the study.
Design a descriptive study to investigate if better meal options will increase patient satisfaction. Include the following elements of design:
1. Develop a research question or purpose of the study
2. Selection of subjects for study (what is the sample)
3. Assignment of subjects to experimental or control groups
4. Study time period
5. Type of data to be gathered
6. Measures of meal options and of patient satisfaction
7. Method of data collection
8. Guidelines for data interpretation
After you complete building the study design, list three design elements you considered in your study that were not readily obvious in the one you read last week “Diagnosed with Breast Cancer While on a Family History Screening Programme: An Exploratory Qualitative Study.”
By Tuesday, February 21, 2017, submit your study design and list of three identified design elements in a Word document to the W3: Assignment 2 Dropbox.
Diagnosed with breast cancer while on a family history
screening programme: an exploratory qualitative study
A. CLEMENTS, bsc, senior research nurse, Cancer Research UK Primary Care Education Research Group,
University of Oxford, Department of Primary Health Care, Oxford, B.J. HENDERSON, phd, research psycholo-
gist, Institute of Medical & Social Care Research, Ardudwy, Normal Site, University of Wales, Bangor, Gwynedd,
S. TYNDEL, ba, research officer, Cancer Research UK Primary Care Education Research Group, University of
Oxford, Department of Primary Health Care, Oxford, G. EVANS, md frcp, consultant in medical genetics,
Department of Clinical Genetics, St Mary’s Hospital, Manchester, K. BRAIN, phd, senior research fellow,
Institute of Medical Genetics, University of Wales College of Medicine, Heath Park, Cardiff, J. AUSTOKER, phd,
director, Cancer Research UK Primary Care Education Research Group, University of Oxford, Department of
Primary Health Care, Oxford, & E. WATSON, phd, deputy director, Cancer Research UK Primary Care Educa-
tion Research Group, University of Oxford, Department of Primary Health Care, Oxford, UK for the PIMMS Study
Management Group*
CLEMENTS A., HENDERSON B.J., TYNDEL S., EVANS G., BRAIN K., AUSTOKER J. & WATSON E. FOR
THE PIMMS STUDY MANAGEMENT GROUP (2008) European Journal of Cancer Care 17, 245–252
Diagnosed with breast cancer while on a family history screening programme: an exploratory qualitative study
Mammographic screening is offered to many women under 50 in the UK who are at moderate or high risk of
developing breast cancer because of their family history of the disease. Little is understoo ...
New methods for reviewing mechanistic evidence
Systematic review guidelines for integrating evidence from human, animal and other mechanistic studies which link diet, nutrition and physical activity to cancer
By Richard Martin, School of Social and Community Medicine, University of Bristol
This document discusses how to evaluate clinical and scientific studies on non-caloric sweeteners. It outlines several key points to consider when assessing different types of studies, such as whether they were published in peer-reviewed literature, who authored them, and potential flaws in study design. The document concludes that well-conducted clinical studies have shown non-caloric sweeteners do not promote weight gain and can aid in weight loss. It also determines aspartame does not cause cancer based on the majority of preclinical studies and large epidemiological studies finding no association.
This document discusses various epidemiological study designs used to assess health outcomes and answer clinical questions. It begins by outlining the 6 D's of health outcomes - death, disease, discomfort, disability, dissatisfaction, and destitution. It then describes key clinical questions and types of epidemiological studies including descriptive studies, analytical observational studies, and experimental/interventional studies. Descriptive studies involve systematically collecting and presenting data to describe a situation, while analytical studies aim to establish causes or risk factors by comparing groups. Specific analytical study designs covered include case-control studies, cohort studies, and randomized controlled trials.
Professor Martin Wiseman presented on 'The Continuous Update Project - Breast cancer survivors and prostate cancer' on behalf of WCRF International at the SCPN conference 04/02/2015.
The document discusses evidence-based periodontology. It defines evidence-based practice and outlines the stages in evidence-based practice, including framing clinical questions and searching for evidence through systematic reviews. Critical appraisal of evidence is important to determine internal and external validity. The best available evidence was searched for various periodontal therapies and procedures, finding that mechanical debridement remains the foundation treatment, while some adjunctive therapies provide modest benefits. A review found reduced pocket depth reduction in smokers compared to non-smokers following nonsurgical periodontal therapy.
Current pediatric research limits and promisesFrancois Cachat
1. Pediatric research has increased dramatically over the last 50 years, especially randomized controlled trials (RCTs) in major academic centers in countries like the US and Europe.
2. However, pediatric research faces challenges like long-term studies, inconsistent findings, limited generalizability and implementation of results.
3. Improving training, mentorship, collaboration and translational research can help address current limitations and further progress pediatric research.
The document discusses different types of epidemiological study designs used to assess whether an exposure is associated with a particular health outcome. It describes experimental (intervention) studies, where investigators allocate subjects to exposure and control groups, and observational studies, where investigators observe naturally occurring exposure and outcome groups. Two main types of intervention studies are clinical trials, which test new treatments among diseased individuals, and field trials, which assess disease prevention among non-diseased individuals. Examples provided examine low-fat diet interventions to reduce breast cancer recurrence and incidence.
Systematic Reviews as a Source of Useful Evidence: The Experience of the EPPI...LIDC
The document discusses the experience of the EPPI-Centre in conducting systematic reviews to inform evidence-based policymaking. It describes how the EPPI-Centre has evolved from initially conducting reviews on clinical interventions to addressing broader social and environmental factors that influence health and development outcomes. The EPPI-Centre has helped establish systematic reviews as an important source of evidence, built global capacity for evidence synthesis, and innovated methods to synthesize different types of qualitative and quantitative data from diverse settings. It has also helped shift understanding from solely clinical models to recognizing social determinants of health and evaluating complex interventions.
The document discusses evidence-based practices in nursing related to breast cancer. It notes the increasing cases of breast cancer have posed challenges for healthcare. Treatments for breast cancer patients have been inadequate, leading to poor health outcomes. Several factors are attributed to the rise in breast cancer cases, including increased screening, lifestyle changes, hormone replacement therapy, and age. The real causes of breast cancer have not been fully established. The document then formulates a research question in PICOT format about monitoring white blood cell counts in cancer patients receiving chemotherapy at home versus at a healthcare facility.
Objective: To evaluate the utility of a targeted lecture in improving FP awareness amongst clinicians.
Design: This is a dual institution, prospective survey-based study assessing if an educational lecture can increase the likelihood of FP consideration, discussion, and referral.
Evidence Based Practice_lecture 5_slidesZakCooper1
This document provides an overview of evidence-based practice as it relates to assessing questions about harm or etiology. It discusses how these types of questions are best assessed through randomized controlled trials or observational studies like cohort and case-control studies. Examples are provided of questions about harm that have been studied, like whether silicone breast implants or weight-loss drugs cause certain health issues. The limitations of different study types are also outlined. Finally, the document discusses how prognosis questions are typically assessed through survival curve analysis and provides some examples of prognosis studies.
Similar to Introduction to World Cancer Research Fund International’s Continuous Update Project (CUP) (20)
A methods document explaining how the NOURISHING database is kept up-to-date with implemented government policies on promoting healthy diets and reducing obesity and non-communicable diseases.
Slides from Alan Jackson's presentation on Policy for Enabling Achievement of Height at Obesity, Physical Activity & Cancer: Life course influences and mechanisms
Slides from Alan Jackson's presentation on the Cancer and Nutrition NIHR infrastructure collaboration at Obesity, Physical Activity & Cancer: Life course influences and mechanisms
The document summarizes a randomized controlled trial that compares intermittent energy restriction (IER) to continuous energy restriction (CER) in women receiving chemotherapy for early breast cancer. The trial aims to test if IER is feasible for women on chemotherapy and to compare the two diets' effects on weight changes, body composition, chemotherapy toxicity, and blood biomarkers. Over 470 women were screened for eligibility, with 172 women enrolled and randomly assigned to receive individual counseling and support for either the IER or CER diet during their 4.5-6 months of chemotherapy. Outcomes will be assessed after chemotherapy completion to analyze differences between the diet groups.
To support governments as they develop national food and nutrition plans and targets, we have produced a new policy brief in collaboration with NCD Alliance.
Senior Policy & Public Affairs Manager, Bryony Sinclair's presentation, Curbing global sugar consumption, at the The Sugar Reduction Summit: Sugar, Sweetness & Obesity, 7 December 2015, London, England.
Professor Alan Jackson’s presentation, The Continuous Update Project: Recent Findings on Diet, Nutrition, Physical Activity and Cancer, at the African Organisation for Research & Training in Cancer (AORTIC) conference, 18-22 November 2015, Marrakech, Morocco.
Bryony Sinclair discussed a systems approach to policymaking for obesity prevention at American Public Health Association's Annual Meeting, 31 Oct - 4 Nov 2015, Chicago, USA.
Professor Michael Leitzmann presentation on The Continuous Update Project: Recent Findings on Diet, Nutrition, Physical Activity and Cancer at FENS European Nutrition Conference, 20-23 October 2015 Berlin (Germany).
This document provides various fundraising ideas that individuals and organizations can do to support the World Cancer Research Fund, including hosting events like quiz nights, dress down days at work, banana runs in the park, and golf tournaments. It also suggests challenges people can take on like skydiving, cycling long distances, and running marathons. The final sentences discuss additional ways to fundraise like recycling ink cartridges, payroll donations, selling pin badges, and donating birthdays or proceeds from online shopping.
This document summarizes findings from the Continuous Update Project (CUP) on diet, weight, physical activity and cancer risk. The CUP analyzes global research on cancer prevention and survival. The summary identifies several factors that increase cancer risk, such as being overweight, eating processed meat, drinking alcohol, and smoking. It also identifies factors that decrease cancer risk, such as eating vegetables, fruits, whole grains, and engaging in physical activity. The CUP findings are used to update the World Cancer Research Fund's Cancer Prevention Recommendations.
Operationalising World Cancer Research Fund/American Institute for Cancer Research Cancer Prevention Recommendations Using an Index Score
ISBNPA 3-6 June 2015
Giota Mitrou PhD MSc
Head of Research Funding & Science External Relations
World Cancer Research Fund International
A coherent approach: effective policy actions for fruits and vegetables throughout the NOURISHING framework.
Bryony Sinclair
Policy and Public Affairs Manager
World Cancer Research Fund International
The document discusses policies that can help reduce sugar consumption to meet WHO guidelines. It provides examples of policies that have successfully reduced the availability of sugary products, increased the acceptability of alternatives, and raised awareness of sugar content. These include school nutrition standards in Australia that eliminated high-sugar "red" foods and drinks from schools, front-of-package labels in the Netherlands that led food companies to reformulate products, and soda taxes in Mexico and France that made sugary drinks less affordable.
Presentation from the World Cancer Congress, 3-6 December 2014, Melbourne, Australia: Reducing the global cancer burden through policy action on diet, physical inactivity and alcohol
Epidemiological evidence linking food, nutrition, physical activity and prostate cancer risk: results from the Continuous Update Project
By Michael Leitzmann, Dept. of Epidemiology and Preventive Medicine, University of Regensburg, Continuous Update Project Panel member
World Cancer Congress, Saturday 6 December 2014
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The Antyodaya Saral Haryana Portal is a pioneering initiative by the Government of Haryana aimed at providing citizens with seamless access to a wide range of government services
Bharat Mata - History of Indian culture.pdfBharat Mata
Bharat Mata Channel is an initiative towards keeping the culture of this country alive. Our effort is to spread the knowledge of Indian history, culture, religion and Vedas to the masses.
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
Indira awas yojana housing scheme renamed as PMAYnarinav14
Indira Awas Yojana (IAY) played a significant role in addressing rural housing needs in India. It emerged as a comprehensive program for affordable housing solutions in rural areas, predating the government’s broader focus on mass housing initiatives.
How To Cultivate Community Affinity Throughout The Generosity JourneyAggregage
This session will dive into how to create rich generosity experiences that foster long-lasting relationships. You’ll walk away with actionable insights to redefine how you engage with your supporters — emphasizing trust, engagement, and community!
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
UN WOD 2024 will take us on a journey of discovery through the ocean's vastness, tapping into the wisdom and expertise of global policy-makers, scientists, managers, thought leaders, and artists to awaken new depths of understanding, compassion, collaboration and commitment for the ocean and all it sustains. The program will expand our perspectives and appreciation for our blue planet, build new foundations for our relationship to the ocean, and ignite a wave of action toward necessary change.
Jennifer Schaus and Associates hosts a complimentary webinar series on The FAR in 2024. Join the webinars on Wednesdays and Fridays at noon, eastern.
Recordings are on YouTube and the company website.
https://www.youtube.com/@jenniferschaus/videos
United Nations World Oceans Day 2024; June 8th " Awaken new dephts".Christina Parmionova
The program will expand our perspectives and appreciation for our blue planet, build new foundations for our relationship to the ocean, and ignite a wave of action toward necessary change.
United Nations World Oceans Day 2024; June 8th " Awaken new dephts".
Introduction to World Cancer Research Fund International’s Continuous Update Project (CUP)
1. Introduction to the WCRF International
Continuous Update Project
Dr Rachel Thompson
Head of Research Interpretation/ Head CUP Secretariat
6 December 2014, UICC World Cancer Congress, Melbourne
2. Underlying principles
Exposures include diet, nutrition and physical activity
Cancers with some evidence of link with above
Identify causal exposures - protective or adverse
Use most robust methods for systematically reviewing
evidence on epidemiology
Epidemiological evidence of a link needs to be supported by
biological mechanisms
Transparency
3. Protocol
(peer
review)
4 Mar 2011
Search for
papers &
add to
database
Analyses &
prepare
report (peer
review)
5 Dec 2012
Draft
discussion
paper and
call with
Panel leads
3 April 2013
Panel
meeting
decisions
25 June
2013
CUP Report
(signed off
by Panel)
PUBLISH
4 Sept 2013
Imperial College London Secretariat Panel Secretariat
4. Grading criteria
Predefined requirements for
Number and types of studies
Quality of exposure and outcome assessment
Heterogeneity within and between study types
Exclusion of chance, bias or confounding
Biological gradient
Evidence of mechanisms
Size of effect
5. Grading the evidence
Decreases risk Increases risk
Strong evidence Convincing
Probable
Limited
evidence
Limited -
suggestive
Limited – no
conclusion
Strong evidence Substantial
effect on risk
unlikely
Basis for recommendations
6. Changes to conclusions for strong evidence since 2007
(except prostate cancer)
Change Exposure Cancer From To
Stronger Foods containing
fibre
Colorectum Probable
decreased
Convincing
decreased
New conclusion Coffee Endometrium No conclusion Probable
decreased
New conclusion Glycaemic load Endometrium No conclusion Probable
increased
New conclusion Body fatness Ovary No conclusion Probable
increased
No conclusion Foods containing
folate
Pancreas Probable
decreased
No conclusion
7. Summary
of strong
evidence
on diet,
nutrition,
physical
activity
and
cancer
8. Mechanisms
Second Expert Report – mechanisms in the form of narrative
reviews (not systematic reviews)
No existing systematic method similar to that followed for
epidemiological studies for the Continuous Update Project
Advisory group led by Steve Hursting identified concepts and
initial work
Working with University of Bristol to develop methodology for
systematically reviewing mechanistic studies (human/animal/cell
lines)
9. Publications timetable
Year Publication
2010 Breast
2011 Colorectum
2012 Pancreas
2013-14 Endometrium, ovary, breast cancer survivors, prostate
2015 Liver, bladder, kidney, gallbladder
2015-16 Stomach, oesophagus, lung
2016-17 Mouth, pharynx, larynx, nasopharynx, breast, colorectum
2017 Review Recommendations for Cancer Prevention
10. For further information
Rachel Thompson
Head of Research Interpretation
r.thompson@wcrf.org
@wcrfint
facebook.com/wcrfint
www.wcrf.org