Professor Martin Wiseman presentation on The Continuous Update Project: Introduction to the Project at FENS European Nutrition Conference, 20-23 October 2015 Berlin (Germany).

1. The Continuous Update Project: Introduction
to the Project
21 October 2015
Martin Wiseman
World Cancer Research Fund International & University
of Southampton

2. Who we are What we do
Fund research on the relationship of nutrition,
physical activity and body weight to cancer
risk
Interpret the accumulated scientific literature to
derive Recommendations for Cancer
Prevention
Educate people through our national Health
Information programmes
Advocate effective policies to help people and
populations to reduce their chances of
developing cancer
AICR
WCRF UK
WCRF Netherlands
WCRF HK
WCRF International

3. 1. New method
2. Systematic reviews
3. Review of evidence separate from
judgement
4. Panel of international experts
5. Predetermined criteria for judgements
Epidemiology
Mechanisms
6. Flexibility
7. Continuous update of evidence
WCRF/AICR EXPERT REPORT
The most authoritative

4. NUTRITION AND CANCERS
• OBESITY
– BREAST (PM), COLORECTUM, ENDOMETRIUM, OESOPHAGUS,
PANCREAS, GALLBLADDER, KIDNEY, LIVER, OVARY, ADVANCED
PROSTATE
• PHYSICAL ACTIVITY
– COLON, POSTMENOPAUSAL BREAST, ENDOMETRIUM
• MEAT – RED AND PROCESSED
– COLORECTAL
• ALCOHOL
– MPL, BREAST, COLORECTUM, LIVER
• FRUIT AND VEGETABLES
– MPL, OESOPHAGUS, STOMACH, COLORECTAL (DF), LUNG
• BREASTFEEDING
– BREAST (MOTHER), OBESITY (CHILD)

5. The Panel emphasises the
importance of not smoking and of
avoiding exposure to tobacco smoke

6. The Continuous Update Project.
Aims
Ensure everyone has access
Based on the most up to date scientific evidence
WCRF/AICR Recommendations for Cancer Prevention:

7. • Keep evidence, conclusions and
recommendations updated into the future
• Working with team at ICL
• Same principles:
- Systematically review evidence
- Meta analysis
- Panel of experts
-draw conclusions
-make recommendations
Continuous Update Project
(CUP)

8. What is the
Continuous Update Project?
Continuous update epidemiologic evidence
(SLR- Imperial College London)
Up-to-date database
Mechanistic evidence
(University of Bristol)
Evaluation of evidence
(Independent panel of experts)
Recommendations
Education, policy and research priorities

9. The Continuous Update
Process

10. Continuous update epidemiologic evidence
(SLR- Imperial College London)

11. CUP Search Literature Review PROTOCOL
(SLR- Imperial College London)
Research topic :
The associations between food, nutrition and physical activity and
 Cancer risk
 Mortality and second cancers in breast cancer survivors.
Main objective :
Summarize the evidence from prospective studies and randomised
controlled trials (case-control studies if requested by the Panel).
Search strategy:
Medline, Central, ClinialTrials.gov
Hand search of references (reviews, meta-analysis, recent relevant
papers)
(http://www.dietandcancerreport.org/cancer_resource_center/downloads/SLR_Manual.pdf)

12. One central database for cancer
prevention research
Team
Database
CUP Expert Panel
WCRF Secretariat

14. Statistical methods
Dose-response meta-analysis using generalized least-squares for trend estimation
(command GLST in Stata)

15. Statistical methods
Publication bias Exploratory analyses

16. Statistical methods
Stratified analyses, sensitivity analyses

17. • Until 2016 - Rolling programme of updates
- Cancer by cancer
• 2016-2017 – Panel review evidence for all
cancers
• 2017 – Statement to be published on evidence
• From 2017 – continue to update and review
evidence
Plan of work

18. Year Publications
2010 Breast
2011 Colorectum
2012 Pancreas
2013 Endometrium
2014 Ovary, prostate and breast cancer
survivors
2015 Liver, kidney, gallbladder, bladder
2015-
2016
Stomach, oesophagus, lung
2016-
2017
Breast, colorectum
2017 Major report – Recommendations
Timeline

19. CUP database

20. CUP report downloads
Total downloads: 4273 vs. 806

21. Journal articles
0
2
4
6
8
Colorectum Pancreas Breast Prostate
8
3 3
1
Numberofarticles
Cancer of
16 published
Includes articles published by ICL (13), WCRF (1), UEA (1) + breast cancer
survivors

23. The Continuous Update Project
Expert Panel

24. www.wcrf.org/int/research-we-fund/continuous-update-project-cup