Key topics covered during this webinar include: Evaluating cardiac contractility using mean or peak aortic acceleration Investigating cardiac relaxation using mitral peak early velocity to peak atrial velocity ratio Interpreting myocardial perfusion capacity through coronary flow reserve at baseline and with disease or other conditions How Doppler Flow Velocity measurements can be used in translational research from mice to mammals In a recent ground-breaking publication in Scientific Reports by Nature Research, Perez et al. highlight the use of noninvasive blood flow velocity measurements to quantify cardiac contractility as a surrogate to +dP/dt max. The article titled “Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse” describes an alternate methodology to what is highly considered the gold standard for evaluating cardiac contractility and relaxation in preclinical research. The acute and terminal nature of acquiring +dP/dt using invasive blood pressure catheters is less than ideal, so finding a noninvasive surrogate is of great interest to the scientific research community. Utilizing a Doppler Flow Velocity System (DFVS) from Indus Instruments, Dr. Reddy and his group show that peak acceleration in the ascending aorta can be used in place of invasive LVP catheters. This novel technique enables serial measurements in the same animal, which reduces animal-to-animal variability, allows for the use of fewer subjects, and decreases data collection time. Please join us during our upcoming webinar on March 4th, 2021 at 11am EST to hear Dr. Reddy present his findings with a LIVE Q&A session at the end. References: Perez, J.E.T., Ortiz-Urbina, J., Heredia, C.P. et al. Aortic acceleration as a noninvasive index of left ventricular contractility in the mouse. Sci Rep 11, 536 (2021)