Antimicrobials - AMINOGLYCOSIDES, AMPHOTERICIN, CEPHALOSPORINS, CHLORAMPHENICOL, METRINIDAZOLE, NITROFURAN, QUINOLONES AND FLUOROQUINOLONES
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Antimicrobials......Rajeshwaree...pharmD ....aminoglycosides : active against aerobic gram neegative baxcteria mechanism of resistance is by modifying enzymes, Inhibit the protien synthesis by binding to
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![AMINOGLYCOSIDES Charectaristics [some]
AMINO
Active against areobic gram negative organisms
Mechanism of resistance is by Modifying
enzymes
Inhibit protein synthesis by binding to 30s
ribosomal subunit
Nephrotoxic
Ototoxic](data:image/gif;base64,R0lGODlhAQABAIAAAAAAAP///yH5BAEAAAAALAAAAAABAAEAAAIBRAA7)
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- 2. AMINOGLYCOSIDES Charectaristics [some] AMINO Active against areobic gram negative organisms Mechanism of resistance is by Modifying enzymes Inhibit protein synthesis by binding to 30s ribosomal subunit Nephrotoxic Ototoxic
- 4. Amphotericin : Side Effects(Toxicity) AMPHET Anemia Muscles Spasms Phlebitis Headache/Hypotension/Hypokalemia Emesis,Encephalopathy Thrombocytopenia
- 6. Cephalosporins:CALM against these Organisms CALM •Clostridium •Active Enterococci •Listeria Monocytogenes •MRSA(Methicillin Resistant Staph)
- 7. :SIDE EFFECTS ome ens uperinfections one marrow Depression rritative Effects ray baby syndrome ypersensitivity reactions
- 8. Disulfiram-like reaction inducing drugs “ ” as in premedical Test in the PM: rocarbazine etronidazole Cefo ( erazone, andole, entan).
- 9. Macrolides: Adverse effects JOG •Jaundice •Ototoxicity •GI disturbance Macrolides/Ketolides: Members TECA •Talithromycin •Erythromycin •Clarythromycin •Azithromycin
- 10. Metronidazole: spectrum action ABCDEFGH & ST Amoebiasis Bacteriods Clostridium perfringes Pseudomembraous Enterocolitis Fusobacterium Giardiasis Helicobacter pylori Anaerobic Strept Trichomonasvaginalis
- 11. Nitrofurantoin: major side effects NitroFurAntoin: ꙮNeuropathy (peripheral nneuropathy) ꙮFibrosis (pulmonary fibrosis) ꙮAnemia (hemolytic anemia)
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- 15. Tetracyclines: adverse effects People Like Going for Versatile Trips •Phototoxicity •Liver failure •GI disturbances •Vertigo •Teeth and Bone toxicity / Teratogenicity
- 16. TEtracyclines : TEratogenicity TEtracycline is a •TEratogen that causes staining of •TEeth in the newborn.