Revolade 75mg is mainly indicated for the treatment of patients having lower platelet levels due to chronic immune thrombocytopenia and chronic hepatitis C virus infection @ Apple Pharmaceuticals

1. INDICATION
DOSAGE
MECHANISM
ADME
PRECAUTION
DRUG INTERACTION
STORAGE
MISSED DOSE
SIDE EFFECTS

2. Revolade 75mg tablet | Apple
pharmaceuticals
 Revolade 75mg is a prescription drug which is used
under the supervision of the doctor.
 Revolade 75mg drug may be used as part of a co-
administration therapy. Hence drug may require
fortaking it with other medications.
INDICATION :
 Revolade 75mg tablet is mainly indicated for the
treatment of patients having :
 lower platelet levels due to chronic immune
thrombocytopenia
 lower platelet counts due to chronic hepatitis C virus
infection

3. Revolade 75mg
Severe aplastic Anemia :
• First line treatment of severe aplastic Anemia
• Treatment of refractory severe aplastic Anemia

4. DOSAGE
Revolade 75mg
Chronic Immune Thrombocytopenia :
The recommended dose of Revolade 75mg has Initial: 50 mg PO qDay
Adjust dose to achieve Control platelet count (Plt) >50 x 10^9/L to reduces
risk of bleeding; not to exceed 75 mg/day

5. Chronic Hepatitis C-associated Thrombocytopenia :
 The recommended dose of Revolade 75mg has Initial: 25
mg PO qDay Dose is Adjust in 25 mg accretion q2weeks
PRN to attain target Plt needed to start/control antiviral
therapy with pegylated interferon and ribavirin; not to exceed
100 mg/day During antiviral therapy, regulate dose to stop
dose reductions of peginterferon Severe Aplastic Anemia
 First-line therapy: Concomitant use with standard
immunosuppressive therapy, for patients with serious
aplastic Anemia (SAA) The recommended dose of Revolade
75mg tablet: 150 mg PO qDay for 6 months Do not give
more than starting dose; total duration is 6 months
Refractory SAA :
 The drug given for this condition who fail to respond enough
to at least 1 before immunosuppressive therapy The
recommended dose of Revolade 75mg: 50 mg PO qDay
Adjust dose in 50-mg accretion q2Weeks PRN to attain
target Plt ≥50 x 10^9/L as required; not exceed 150 mg/day;
may take up to 16 weeks for hematologic response.

6. MECHANISM
 Eltrombopag belongs to growth factors which excite platelet
production through the thrombopoietin (TPO) receptor.
 Eltrombopag is a thrombopoietin nonpeptide agonist which
have high platelet counts by binding to and activating the TPO
receptor. It stimulates pathways within the cell to raises the
production and development of marrow progenitor (parent) cells
to strengthen platelet production.

7. ADME
Absorption:
 peak plasma concentration is 2-6 hours
Distribution:
 highly human plasma protein bounding is >99% and in blood
plasma level is 50% to 79%
Metabolism:
 predominantly metabolised through cleavage, oxidation and
conjugation with glucuronic acid.
Elimination:
 Revolade 75mg eliminated primarily via feces 59%, along
with 31% via renally excreted
 Half-life of Revolade 75mg healthy patients is 21-23 hours
and idiopathic thrombocytopenic purpura is 26-35 hours.

8. PRECAUTION
 The drug causes warning condition call the doctor while new
medication interaction If other blood clot risk factors, then
avoid the drug because it will high level of platelet counts
and blood clots.
 If the patients have cataracts, avoid the drug due to the drug
effects cataracts and make the condition worse.
 Disease progression warning: Avoid using the drug while the
patients have myelodysplastic syndrome (MDS), will
increases the risk of death.

9. DRUG INTERACTION
 Revolade 75mg co administration with these drugs
ezetimibe, glyburide, Olmesartan, repaglinide, valsartan,
imatinib, irinotecan, lapatinib, methotrexate, mitoxantrone,
Bosentan, sulfasalazine, and topotecan irinotecan leads
increase of side effects. hence the doctor may reduce your
dosage of these drugs if required.
 Revolade 75mg tablet concomitant use with Cholesterol-
reducing drugs like atorvastatin, fluvastatin, rosuvastatin,
pravastatin, and simvastatin, pitavastatin. Have high side
effects can contains muscle pain. The doctor may decrease
the dosage of your cholesterol drugs.
 Revolade 75mg combination with Antacids, vitamins, or
supplements which involves Ca, Al, Fe, Se, Zn, or Mg. To
stop interactions, then take Revolade two hours before or
four hours after administrating any of these products.

10. STORAGE
 Store at room temperature 20°C and 25°C.
 Discard the left-out medicine if not used within 30 minutes
MISSED DOSE
 In case of missed dose, patients must consult with medical
practitioner and follow the instructions given by them.
thereby missed dose should be avoid and follow the regular
dosing schedule.

11. SIDE EFFECTS
 Lack of appetite
 flu
 diarrhoea
 Urine in dark colour
 Yellowing of your skin
 low red blood cells
 nausea
 fever
 weakness
 pain in head
 cough

12.  Abdomen swelling
 Confusion
 Chest pain
 Dyspnea
 Cloudy vision
 Sensitivity to light
 Seeing circles around lights
 Swelling of legs

13. CONTACT DETAILS
 Phone : 9987711567
 Email : applepharmaceutical@gmail.com
 Email : info@myapplepharma.com
 Website : https://myapplepharma.com/eltrombopag-
75mg.php