This document discusses inflammation, non-steroidal anti-inflammatory drugs (NSAIDs), and ibuprofen specifically. It notes that inflammation is a normal process initiated by stimuli like injury to facilitate tissue repair. NSAIDs are commonly prescribed and over-the-counter drugs that work by decreasing prostaglandin production through inhibiting cyclooxygenase enzymes. Ibuprofen is one of the most frequently used NSAIDs, introduced over-the-counter in 1985, and used for fever reduction and pain relief in both adults and children due to its longer duration than acetaminophen.

1. BY,
SUJAY KUMAR
SHETTY
161243
ANTIINFLAMMATORY AGENTS

2. INFLAMMATION PROCESS
 A normal, beneficial process that begins
immediately after injury to facilitate repair
and return the tissue to normal function
and ƒInitiated by stimulus including
physical trauma, radiation, chemicals, heat,
infection, and hypersensitivity infection, ƒ
Causes the release of chemical mediators.

3. NON STEROIDAL ANTIINFLAMMATORY
DRUGS
 Most frequently prescribed and frequently
used OTC drugs ƒ
 Major mechanism of action is to decrease
PG production by inhibiting one decrease or
both of the cyclo oxygenase isoforms (COX-
1, COX-2)
 COX-2 is enhanced in response to pain and
inflammation so NSAIDs primarily inhibit
this isoform rather than both COX -1 and
COX 1 and COX-2.

4. Ibuprofen
 Advil, Motrin, Nuprin
 Most frequently used NSAID
 Introduced to the OTC market in 1985, it is
available in 200 to 800 mg tablets by
prescription, and 200 mg tablets OTC
 Frequently used as an antipyretic in adults
and children, as its longer duration of action
makes it a popular alternative to
acetaminophen

5. SYNTHESIS OF IBUPROFEN

6.  Peak plasma levels are achieved within 15
to 30 minutes of ingestion
 Rapid onset of action can be quite
beneficial for quick relief of pain
 Half-life of about 2 hours, it must be taken
every 6 to 8 hours to maintain effect
 An anti-inflammatory regimen requires
2400 – 3200 mg daily

7.  Taken in three separate doses, allowing it to
be taken at meal times, lessening the
likelihood of gastric irritation.
 Sufficient analgesia should be achieved by
daily dosages of less than 2400 mg per day.
 Approximately 10 percent to 15 percent of
individuals must discontinue use secondary
to gastrointestinal symptoms