Search Results Featured snippet from the web Nonsteroidal anti-inflammatory drugs, or NSAIDs (pronounced en-saids), are the most prescribed medications for treating conditions such as arthritis. Most people are familiar with over-the-counter, nonprescription NSAIDs, such as aspirin and ibuprofen. NSAIDs are more than just pain relievers. Here is the short note on NSAIDs. If any incorrect details provided here please correct it in the comment section. It will help you & me also

1. KHWAJA YUNUS ALI UNIVERSITY
QUEST FOR KNOWLEDGE………
Assignment On
NSAIDs
Course Name: Advanced Medicinal Chemistry
Course Code: BPH 4101
Submitted By: Submitted To:
Date of Submission: 10-08-2020
Naznin Shahria
Senior Lecturer
Department Of Pharmacy
Khwaja Yunus Ali University
Quazi Istiaque Bari
ID No: 2017301030007
4th
year 1st
semester
Batch- 8th
Department Of Pharmacy
Khwaja Yunus Ali University

2. NSAIDs
Nonsteroidal anti-inflammatory drugs (NSAIDs) are members of a drug class that reduces pain,
decreases fever, prevents blood clots, and in higher doses, decreases inflammation.
Example- Aspirin, paracetamol, ibuprofen, ketoprofen, diclofenac etc.
Classification of NSAIDs:
A. Nonselective COX
inhibitors (traditional
NSAIDs)
1. Salicylates: Aspirin.
2. Propionic acid
derivatives: Ibuprofen,
Naproxen, Ketoprofen,
Flurbiprofen.
3. Fenamate: Mephenamic
acid.
4. Enolic acid derivatives:
Piroxicam, Tenoxicam.
5. Acetic acid derivatives:
Ketorolac, Indomethacin,
Nabumetone
6. Pyrazolone derivatives:
Phenylbutazone,
Oxyphenbutazone.
B. Preferential
COX-2 inhibitors
 Nimesulide,
 Diclofenac,
 Aceclofenac,
 Meloxicam,
 Etodolac.
C. Selective COX-2
inhibitors
 Celecoxib,
 Etoricoxib,
 Parecoxib
D. Analgesic-antipyretics
with poor
antiinflammatory action
1. Paraaminophenol
derivative: Paracetamol
(Acetaminophen).
2. Pyrazolone derivatives:
Metamizol (Dipyrone),
Propiphenazone.
3. Benzoxazocine
derivative: Nefopam.

3. Mechanism of action of NSAIDs:
COX-2
(Inducible)
NSAIDs
Prostaglandins Prostaglandins
GI protection
Platelet activation
Inflammation
Fever
Pain
Cell damage
Membrane phospholipid
Arachidonic acid
Flow chart of mechanism of action of NSAIDs