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David Servan-Schreiber,  MD, PHD Clinical Professor of Psychiatry, University of Pittsburgh Ajct Professor of General Oncology, M.D. Anderson Cancer Center, Univ. of Texas Lecturer, Faculté de Médecine Lyon I Anticancer A Personal and Scientific Journey
A Story ,[object Object]
A Lesson ,[object Object],[object Object],[object Object],[object Object]
Tumor and Terrain ,[object Object],[object Object]
Epidemic 1 - Evolution SEER, 2003 NCI
Childhood Cancers  Steliarova-Foucher et al., 2005  Lancet
Epidemic 2 -   Distribution
Key difference = Life style For 100,000 Sasco, 1989 Rev Med Int
Health Busters A Watershed in 1945 ,[object Object],[object Object],[object Object],[object Object],[object Object]
Refined Sugar WW I WW II
 
Glycemic Load and ER+/PR- Breast Ca Larsson et al., 2009 Int. Jnal. Cancer
 
Soy Oil (omega-6)
 
Evolution of Diet Saturated Fat Omega-6 Fatty Acids Omega-3 Fatty Acids % Calories 10 20 - 4M - 10,000 1800 1900 2000 WW II Leaf, A. and P. Weber Am. Jal. Clin. Nut. 1987
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Chemical Contamination
Pesticides ,[object Object],[object Object],[object Object]
Sun Light is a Vitamin 20 min = 20,000 IU of Vitamin D
Colon Cancer and Solar Radiation Garland et al, 2006 Am. J. Pub. Health
Breast Cancer and Sun Exposure Garland et al, 1990 Prev. Med.
Health Boosters
 
Synergy of Natural Defenses Pierce et al., 2007 Jnal Clin. Onc.
Andersen et al., 2008 Cancer Life Style Changes Post-Treatment Intervention Control 68% reduction in mortality
Anticancer Phytochemicals Surh, 2003 Nature
Specific Activity Boivin et al., 2008 Food Chem.
Anticancer Plate
Helplessness and Tumor Growth
Stress and Support ,[object Object]
 
Friends ,[object Object],[object Object],[object Object],[object Object],Kroenket al., 2006 Jnal Clin. Onc.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Cancer = loss of equilibrium
To be continued…
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Mobile Phone Electromagnetic Penetration Gandhi et al, 1996 IEEE Transac.
Mobile Phones and  Blood-Brain Barrier Salford et al, 2003  Env. Health. Persp.
Gliomas Hardell et al, 2008  Int Jal Onc. Relative Risk
Organic vs Conventional Food ,[object Object],[object Object],[object Object],Curl et al., 2003 Env. Health. Persp.
Ailhaud et al., Prog. Lip. Res., 2006 – Simopoulos & Salem. NEJM, 1989 Omg-6 /Omg-3 x6 x10 x15 x20 Transformation of food chain
Food Synergies Zhang, et al. 2009  Int. J. Cancer -89%
Cancer Genes ?
BRCA 1- 2 and Variety of Vegetables Ghadirian et al. 2009, Breast Ca. Res. Treat. Vegetables and Fruits in Diet -73% -73%
Prostate Cancer and Fish Fradet al. 2009 Clin Ca Res
Stress Does Not Cause Cancer ,[object Object],[object Object],[object Object],Lillberg et al., 2001 Int J Cancer
What kind of stress? Visintainer & Seligman, 1982 Science % Tumor rejection 54% 23% 63% No Shock Shock –  no Control Shock  + Control
Support vs. Helplessness ,[object Object],[object Object],[object Object],[object Object],Price et al., 2001 Cancer 9.5
Change in Gene Expression Ornish et al., 2008  Proc Nat Acad Sci , USA
Synergy Pulmonary Adenocarcinoma -  Lamy et al. In sub Cancer Res Reguar Diet +Vegetable cocktail
Organic or Conventional?
Synergy  in vitro Liu et al., 2004, J Nut
Household Products ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anti-perspirant and Shaving McGrath et al., 2003  Eur Jnal Ca Prev ,
 

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Anticancer by David Servan-Schreiber

Editor's Notes

  1. Start story of ancestors here…