This document summarizes evidence on potential links between endocrine disrupting chemicals (EDCs) and breast cancer risk. It discusses studies finding associations between breast cancer and exposures like diethylstilbestrol (DES), post-menopausal hormone use, organochlorines like DDT and dieldrin, polychlorinated biphenyls, and chemicals in the home and workplace like phthalates and bisphenol A. While evidence is mixed, some chemicals appear to modestly increase risk, and windows of exposure during development may be important to consider.
Some chemicals, both natural and man-made, can interfere with the hormonal system. They are called 'endocrine disruptors’. The most controversial issue is whether low level exposures to such chemicals can have adverse effects. Have endocrine disruptors affected wild life and our hormonal system? How much do we know so far?
What are Endocrine-disrupting chemicals (EDCs)?
What products contain endocrine disruptors?
How do endocrine disruptors work?(its Mechanisms of Action).
How are people exposed to endocrine disruptors?
Endocrine disrupting chemicals and their heath effects.
Pesticides:( DDT),human health consequences of exposure to DDT,and its scientific evidence and examples.
Steps to reduce exposure to endocrine disruptors
VCE Environmental Science - Unit 4: Pollution. The sources, sinks, human and environmental health effects of DDT and endocrine disruptors, including pthalates, are discussed in this presentation.
what are EDCs, impacts/effects of EDCs, Sources, treatment of EDC by various methods such as activated carbon, phytoremediation, membrane fouling during ultrafiltration, constructed wetlands, the advanced oxidation process
Endocrine Disruptors: Child healths
Vichit Supornsilchai, MD, PhD
Endocrine Unit, Department of Pediatric,
Faculty of Medicine,
King Chulalongkorn Memorial Hospital
Some chemicals, both natural and man-made, can interfere with the hormonal system. They are called 'endocrine disruptors’. The most controversial issue is whether low level exposures to such chemicals can have adverse effects. Have endocrine disruptors affected wild life and our hormonal system? How much do we know so far?
What are Endocrine-disrupting chemicals (EDCs)?
What products contain endocrine disruptors?
How do endocrine disruptors work?(its Mechanisms of Action).
How are people exposed to endocrine disruptors?
Endocrine disrupting chemicals and their heath effects.
Pesticides:( DDT),human health consequences of exposure to DDT,and its scientific evidence and examples.
Steps to reduce exposure to endocrine disruptors
VCE Environmental Science - Unit 4: Pollution. The sources, sinks, human and environmental health effects of DDT and endocrine disruptors, including pthalates, are discussed in this presentation.
what are EDCs, impacts/effects of EDCs, Sources, treatment of EDC by various methods such as activated carbon, phytoremediation, membrane fouling during ultrafiltration, constructed wetlands, the advanced oxidation process
Endocrine Disruptors: Child healths
Vichit Supornsilchai, MD, PhD
Endocrine Unit, Department of Pediatric,
Faculty of Medicine,
King Chulalongkorn Memorial Hospital
Who this is for: Health professionals.
Description: Dr. Sheila Bushkin-Bedient will be speaking on the prenatal origins of disease and why we should be focusing on studying possible connections between unconventional natural gas extraction and diabetes, obesity, and cancer.
About the Speaker: Sheila Bushkin is a member of the Institute of Health and the Environment at the State University at Albany, and Concerned Health Professionals of New York. She has been a member of the Medical Society of the State of New York for 15 years. Her specific areas of interest involve environmental health issues, chronic diseases, health concerns of older adults, and CME for physicians.
Toxicology
is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants.
Toxicity
is the degree to which a chemical substance or a particular mixture of substances can damage an organism
History
Ecotoxicology is a relatively young discipline that made its debuts in the 1970s
Ecotoxicology emerged after pollution events that occurred after World War II heightened awareness on the impact of toxic chemical and wastewater discharges towards humankind and the environment
The term « Ecotoxicology » was used for the first time in 1969 by René Truhaut, a toxicologist, during an environmental conference in Stockholm.
Dr. Zahida Chaudhary and James Ellermeyer talk about toxins in our environment, including what they do to our body. They also take a look specifically at DDT and the process of it getting into the public long before we could determine it’s negative effects.
Want an audio version? Subscribe to our Podcast on iTunes!
Follow the Educational Grand Rounds Playlist on Youtube!
Want to join us for the live discussion? Check out our Social Media in the noon hour every Monday as we sit down on Google Hangout OnAir! Follow us on Twitter, Facebook, or Google+ to get updated with the link when we start!
Based on money and Materials Our modern life became a big illusion. The Real life and happiness needs 1- Security 2- Health 3- Life essentials (food – shelter etc). The Real life and happiness lie behind a natural life in a clean environment. We are sinking in different types of pollution. The consequences of pollution include: 1- Climate change the Heat melts ice, worsens weather and expands oceans. 2- Human health effects a- Climate changes b- Pollutants. 3- Plants and animals Natural habitats become hostile. Pollution is a Global Problem with no but a Single must be a Global Solution that is Go Green, Reduce CO2 and Stop Pollution
Who this is for: Mothers and families
Description: Dr. David O. Carpenter will focus on environmental exposures that are known to result in reduced cognitive function in children, usually associated with shortened attention span, increased antisocial behavior and poorer performance in school.
About the Speaker: Carpenter is a public health physician whose current position is Director of the Institute for Health and the Environment at the University at Albany, as well as Professor of Environmental Health Sciences within the School of Public Health at the University at Albany. After receiving his MD degree from Harvard Medical School he chose a career of research and public health.
Endocrine Disruptors presentation will inform our readers about different disruptors that affect the everyday lives of people: BPA, MethylMercury, Pesticides, Phthalates, and Soy all these will inform the reader about the hazards, exposure, and the alternatives behind these disruptors.
Increasing Trends in Male Reproductive Disorders, Environmental Exposures, an...DES Daughter
On this call, Dr. Skakkebaek presented his concerns about increasing trends in male reproductive disorders, including the significant global increase in incidence of germ cell tumors. He and colleagues from all over the world demonstrated that over half of all young men's semen quality does not meet the reference standard of the World Health Organization. Dr. Skakkebaek presented evidence linking testicular cancer, poor semen quality, childlessness, and rapidly decreasing fertility rates. He showed how there is little doubt that environmental factors, most likely associated with modern lifestyles, have - in a broad sense - had an adverse influence on male reproductive health. He and his group are examining a fundamental role that exposure to endocrine-disrupting chemicals may play in these trends, trends that in a few decades will result in decreasing populations in industrialized countries, and believes collaborative research is required to identify the causes of these adverse trends.
Sources: http://healthandenvironment.org/partnership_calls/18355
Who this is for: Health professionals.
Description: Dr. Sheila Bushkin-Bedient will be speaking on the prenatal origins of disease and why we should be focusing on studying possible connections between unconventional natural gas extraction and diabetes, obesity, and cancer.
About the Speaker: Sheila Bushkin is a member of the Institute of Health and the Environment at the State University at Albany, and Concerned Health Professionals of New York. She has been a member of the Medical Society of the State of New York for 15 years. Her specific areas of interest involve environmental health issues, chronic diseases, health concerns of older adults, and CME for physicians.
Toxicology
is a scientific discipline, overlapping with biology, chemistry, pharmacology, and medicine, that involves the study of the adverse effects of chemical substances on living organisms and the practice of diagnosing and treating exposures to toxins and toxicants.
Toxicity
is the degree to which a chemical substance or a particular mixture of substances can damage an organism
History
Ecotoxicology is a relatively young discipline that made its debuts in the 1970s
Ecotoxicology emerged after pollution events that occurred after World War II heightened awareness on the impact of toxic chemical and wastewater discharges towards humankind and the environment
The term « Ecotoxicology » was used for the first time in 1969 by René Truhaut, a toxicologist, during an environmental conference in Stockholm.
Dr. Zahida Chaudhary and James Ellermeyer talk about toxins in our environment, including what they do to our body. They also take a look specifically at DDT and the process of it getting into the public long before we could determine it’s negative effects.
Want an audio version? Subscribe to our Podcast on iTunes!
Follow the Educational Grand Rounds Playlist on Youtube!
Want to join us for the live discussion? Check out our Social Media in the noon hour every Monday as we sit down on Google Hangout OnAir! Follow us on Twitter, Facebook, or Google+ to get updated with the link when we start!
Based on money and Materials Our modern life became a big illusion. The Real life and happiness needs 1- Security 2- Health 3- Life essentials (food – shelter etc). The Real life and happiness lie behind a natural life in a clean environment. We are sinking in different types of pollution. The consequences of pollution include: 1- Climate change the Heat melts ice, worsens weather and expands oceans. 2- Human health effects a- Climate changes b- Pollutants. 3- Plants and animals Natural habitats become hostile. Pollution is a Global Problem with no but a Single must be a Global Solution that is Go Green, Reduce CO2 and Stop Pollution
Who this is for: Mothers and families
Description: Dr. David O. Carpenter will focus on environmental exposures that are known to result in reduced cognitive function in children, usually associated with shortened attention span, increased antisocial behavior and poorer performance in school.
About the Speaker: Carpenter is a public health physician whose current position is Director of the Institute for Health and the Environment at the University at Albany, as well as Professor of Environmental Health Sciences within the School of Public Health at the University at Albany. After receiving his MD degree from Harvard Medical School he chose a career of research and public health.
Endocrine Disruptors presentation will inform our readers about different disruptors that affect the everyday lives of people: BPA, MethylMercury, Pesticides, Phthalates, and Soy all these will inform the reader about the hazards, exposure, and the alternatives behind these disruptors.
Increasing Trends in Male Reproductive Disorders, Environmental Exposures, an...DES Daughter
On this call, Dr. Skakkebaek presented his concerns about increasing trends in male reproductive disorders, including the significant global increase in incidence of germ cell tumors. He and colleagues from all over the world demonstrated that over half of all young men's semen quality does not meet the reference standard of the World Health Organization. Dr. Skakkebaek presented evidence linking testicular cancer, poor semen quality, childlessness, and rapidly decreasing fertility rates. He showed how there is little doubt that environmental factors, most likely associated with modern lifestyles, have - in a broad sense - had an adverse influence on male reproductive health. He and his group are examining a fundamental role that exposure to endocrine-disrupting chemicals may play in these trends, trends that in a few decades will result in decreasing populations in industrialized countries, and believes collaborative research is required to identify the causes of these adverse trends.
Sources: http://healthandenvironment.org/partnership_calls/18355
Endocrine disruptors in the healthcare sectorDES Daughter
Created for healthcare professionals on EDCs, this slideshow by Health Care without Harm Europe (HCWH) examines the reasons why we should be concerned, who is at risk, including on pregnant women and babies, and where EDCs are hidden in the healthcare sector.
Sources: https://noharm-europe.org/documents/presentation-slides-webinar-edcs-healthcare
Leaflet: https://noharm-europe.org/documents/edc-leaflet-health-professionals
Endocrine Disruption and Immune DysfunctionDES Daughter
by the Collaborative on Health and the Environment
On this first in a series of calls on endocrine disrupting chemicals, Dr. Rodney Dietert discussed how the immune system is a target for endocrine disrupting chemicals, particularly during development. Numerous relatively ‘hidden’ effects can ensue from a single risk factor and emerge over a lifetime. He also discussed how current safety testing fails to appropriately assess misregulated inflammation as the greatest immune based health risk.
Sources: http://www.healthandenvironment.org/partnership_calls/13389
Antimicrobial resistance is one of the biggest threats to human health and is rising to dangerously high levels in all parts of the world. Anyone, of any age, in any country, could be impacted. While it's normal for microbes to develop resistance to drugs, the way antimicrobials are currently being used is accelerating the process, and as a result common infections and minor injuries are becoming an increasingly greater threat to our well-being. Organizations from across the world are taking action and making progress on this issue, but is there anything patients, their families and patient advisors can do to help?
See the full presentation here: https://goo.gl/AYCsdd
TOPIC: “Chemical Exposures & Life-Long Reproductive Health Impacts”
We will review what we understand about reproductive biology and environmental contamination exposure. We’ll discuss the role of environmental chemicals in breast development and puberty, increased susceptibility to breast cancer and exposures during early life development of both male and female offspring and life-long impacts from chemical exposure. We’ll also discuss some of the potential health implications of energy development based on what we currently understand about exposures during early reproductive and developmental biology.
SPEAKER BIO: Suzanne Fenton, Ph.D., is Group Leader, NIH, Reproductive Endocrinology Group, Mammary Gland Development/Lactation Biology and a reproductive endocrinologist working at the National Toxicology Program Laboratory with the Division of the National Toxicology Program at National Institute of Environmental Health Sciences.
Breast cancer is the leading cause of death from cancer among women, accounting for 23% of the total cancer cases and 14% of cancer deaths in 2008. As dietary fat is thought to be one of the main risk factors, this webinar will focus on the opposing effects of the omega-6 fatty acid arachidonic acid (AA) and the omega-3 fatty acid eicosapentaenoic acid (EPA) on factors related to breast cancer risk, development and prognosis, including their influence on cyclooxygenase activity and prostaglandin production, the impact of inflammation within the tissue microenvironment, impact on aromatase and oestrogen production and impact on genetic aspects of breast cancer such as modulation of BRAC1 and BRAC2 genes.
Levels of Dichlorodiphenyltrichloroethane (DDT) and Hexachlorocyclohexane (HC...Premier Publishers
Serum levels of Dichlorodiphenyltrichloroethane (DDT) and Hexachlorocyclohexane (HCH) of breast cancer patients and controls were compared with a view to determining association between exposure of organochlorine pesticides (OCPs) and breast cancer. Fifty breast cancer patients and fifty age-matched control women were recruited from the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. Questionnaires were administered to collect information on demography and essential breast cancer risk factors. Five millilitres of blood was collected from each participant and the serum was analysed for DDT and HCH using Gas Chromatography coupled with Electron Capture Detector. The results showed that almost all case women had no identifiable risk factors for breast cancer. The median DDT levels among case and control women were 11.87 ppb and 6.395 ppb, respectively. The levels of δ-HCH among case and control women were 5.82 ppb and 0.00 ppb while that of γ-HCH were 10.84 ppb and 0.00 ppb, respectively. This study confirmed exposure to OCPs among the studied population and revealed significantly higher levels (p≤0.05) in case women than controls, thereby, suggesting that exposure to OCPs may be a significant risk factor for breast cancer in Nigeria.
To gain more insight about the environmental impact on your risk of developing breast cancer, I strongly suggest you view this presentation. These slides will help you understand the way these pesticides/herbicides and other estrogen mimickers affect your breast tissue. They will also help to explain the “Before & After” images on our website. This is crucial for an understanding of how cancers respond in a metabolic or physiological way.
David Servan-Schreiber, M.D., Ph.D., is the author of the NY Times best seller "AntiCancer". Here is a review of his findings and some recommendations. David successfully battled brain cancer for 19years but unfortunately passed away last July. His latest book is titled "Not the last goodbye" published by Viking in December 2011.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
Breast Cancer - Is there a link to endocrine disrupting chemicals? Breast Cancer - Is there a link to endocrine disrupting chemicals?
1. Breast Cancer – Is there a link to Endocrine Disrupting Chemicals? Suzanne M. Snedeker, Ph.D. Assoc. Director for Translational Research Cornell University’s Program on Breast Cancer and Environmental Risk Factors (BCERF) [email_address] http://www.cfe.cornell.edu/bcerf/
2. 2nd Copenhagen Workshop on Endocrine Disrupters: A Possible Role of Mixed Exposures for Reproductive Failures and Malignancies Session 1: EDC Effects in Humans December 7th, 2002 Rigshospitalet (Copenhagen University Hospital) Copenhagen, Denmark Presented at the:
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5. Risks Related to Breast Cancer Advancing Age Genetics Alcohol Hormone Therapy Gender Close Relative Benign Breast Disease Early Menarche Age at First Birth Passive Smoke Education & Income Overweight (post-menopause) Lack of Exercise Chemicals - Work -Home -Garden -Recreation Late Menopause Breast Feeding ??? Diet Ionizing Radiation
15. Post-menopausal hormone use – Breast cancer risk, Nurses Health Study Ref: Colditz and Rosner, American J Epidemiology, 152:950-964, 2000 HRT, Estrogen + Prog., 10 yrs ERT, Estrogen unopposed, 10 yrs ERT, Estrogen unopposed, 5 yrs Non-users, solid line
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27. Endocrine disrupting chemicals – Phthalates and Premature Thelarche in Puerto Rican Girls Phthalate esters Average conc. in serum, ppb Ref: Colon et al., Environmental Health Perspectives, 108:895-900, 2000
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31. Endocrine disrupting chemicals -Understanding susceptibility Ref: Russo and Russo, Oncology Research, 11:169-178, 1999 E2 Growth Hormone IGF Human breast development