This document provides information about various types of anti-ulcer drugs, including their mechanisms of action and effects. It discusses anti-pyloric drugs/antibiotics that treat ulcers caused by H. pylori and C. pylori bacteria. It also describes antacids that neutralize stomach acid, drugs that decrease stomach acid secretion like H2 receptor blockers and proton pump inhibitors, and ulcer protective drugs like sucralfate and colloidal bismuth that coat and protect ulcer bases. Finally, it mentions ulcer healing drugs that stimulate mucus secretion to increase gastric mucosal protection and healing.

1. ANTI ULCER DRUGS
Name – Soumyakanti Maity
Roll no. – 19301916028
Stream - B. Pharm
Semester - 5th semester
BENGAL SCHOOL OF YECHNOLOGY
Subject- Medicinal Chemistry
PT-503
Guided by- Omprakash Panda
(Assistant Professor)
Bengal School of Technolgy

2. ANTI ULCER DRUGS
Anti pyloric drugs / Antibiotics
Antacids
Drugs decrease HCL secretion
Ulcer protective
Ulcer healing drugs
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3. ANTI PYLORIC DRUGS
USED WHEN CASE OF ULCER ARE C.PYLORI AND H.PYLORI
 Macrolide antibiotic(Clarithromycin)-
MOA- Inhibit protein synthesis
 Beta lactam antibiotic(Amoxicillin)-
MOA- Inhibit cell wall formation
 Nitroimidazole dvt. (Tinidazole, Ornidazole)-
MOA- cedar in nature (reduction of their Nitro group and formation of
metabolite that bind with
DNA and interferes its functions
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4. ANTACID
MOA- neutralize gastric HCl.
Ideal antacid should not increase gastric pH NMT5 (otherwise Chan es of re bound
hyperacidity occurs)
Antacids should not be given with enteric coated tablet. Otherwise enteric coating
will dissolve in stomach. Because antacid increases the stomach pH.
During acid neutralization foam formation occur
it will cause oesophagus burn
so it is must to add antifoaming agent or dispersing agent (HLB value =1-3)
These are the essential component of antacid . Eg Polysiloxane (Simethicone,
Dimethicon).
Formulation available in market-
 Suspension
 Chewable tablet
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5. ANTACID
Type of antacids
• Systemic antacid
• Non systemic antacid
Systemic antacid- Absorb systematically.
NaHCO3 + HCl NaCl + CO2 + H2O
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S/e-Systemic alkalosis Absorb systematically
S/e-
Flatulence
Preformation of ulcer
base( increase area )
Bleaching.
Increase blood osmotic
pressure
( increase Na+
content)
C/I – in heart disease
CHF
Inchemic heart disease
Hypertension.

6. ANTACID
• Non systemic antacid – Poorly absorbable
• Al(HO)3 gel- Slowly acting
S/e- decrease GIT moiety- cause constipation
• Mg(HO)3 – solution strength 7.5% w/v so called as MILK OF MAGNISIA(due to its milky
appearance.
S/e- Diarrhoea(laxative action, increase GIT motility)
• CaCO3-
• Most potent antacid
• Fast acting antacid
S/e- Rebound acid secretion ( Reflux acid secretion occur due to fast neutralize HCl)
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7. DRUGS DECREASE HCL SECRETION
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Anticholinergic
drugs-
• piperazine
Prostaglandin
analogue-
• Rioprostel
• Misoprostel
• Enoprostil etc.
H2 receptor
blocker/ H2
antihistaminic
• Cimetidine
• Famotidine
Proton pump
inhibitors
• Omeprazole
• Pantoprazole
• Esomeprazole

8. PHARMACOKINETICS
• Absorbed rapidly and completely except for famotidine;
food and antacids may reduce absorption; distributed
widely throughout the body; metabolized by the liver;
excreted primarily in the urine .
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9. THERAPEUTIC EFFECT
• Used therapeutically to:
• Promote healing of duodenal and gastric ulcers.
• Provide long-term treatment of pathological GI hypersecretory
conditions.
• Reduce gastric acid production and prevent stress ulcers.
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10. ULCER PROTECTIVE DRUGS
• +
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Eg – sucralfate , colloidal bismuth substrate (CBS)
Sucralfate
Chemically- it is Al salt of sulphated sucrose
S/E – constipation due Aluminium
hypophosphatemia
D/1
Tetracycline Sucralfate
Form complex with aluminium
Decrease the absorption of
tetracycline
MOA
Assume gel like consistency at pH<4 by
cross linking of its molecules
Coat ulcer base & also ppt surface
protein
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11. Colloidal bismuth substrate (CBS)
MOA- 1. Foam complex with glycoprotein coat ulcer base
2. Increase PGE2 synthesis Increase mucosal blood supply Increase
healing of ulcer.
3. Kill the bacteria which are responsible for ulcer
• S/e – Osteodystrophy etc.
Ulcer Healing drugs
these drugs act by increasing thick mucous secretion by goblet cells
MOA Stimulate goblet cells
Increase thick mucous secration
Increase life spam of gastric
mucosal cell
Eg.- Carbenoxolone sodium
deglycyrrhinized liquorice
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12. REFERENCE:
• D. Sriram, P. Yogeeswari ,Medicinal chemistry , Second Edition, Page no-277.
• Thomas L. Lemke, David A. Williams, Victoria F. Roche, S William Zito Foye’s,
Principles of Medicinal Chemistry, Seventh edition.
• K.D. Tripathi, Essential of Medical Pharmacology, Seventh Edition, page no-
653-659.
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13. THANK
YOU
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