This document defines and discusses angioedema. There are four main types of angioedema: idiopathic, drug-induced, allergic, and hereditary. Angioedema is characterized by localized swelling caused by increased permeability of capillaries. It can affect areas with loose connective tissue like lips, eyelids, and scrotum. Causes include medications, foods, allergens, and underlying conditions. Diagnosis involves blood tests and prick tests. Complications include airway blockage. Treatment focuses on antihistamines, corticosteroids, epinephrine shots, and prevention.

1. Angioedema
Layla almzraq

2. Case summary
Main problem
history

3. Learning objectives cont:
Definition of angioedema.
Types of angioedema.
Pathophysiology of angioedema.
Causes and risk factors of angioedema.
Signs and symptoms of angioedema.
Differences between angioedema and urticaria.

4. Learning objectives cont:
Diagnosis of angioedema.
Complication of angioedema.
Treatment of angioedema.

5. Atopy
• A state of increased sensitivity to common antigens (for
example house dust, animal certain foods or chemical
irritants ) with increased production of IgE.

6. • The most common types of Atopy include:
• Allergic asthma
• Eczema
Atopy cont…

7. •Fluid accumulates below the dermis. More evident in areas of
loose connective tissue such as: eyelids, lips, scrotum
• It is a vascular reaction involving the deep dermis or
subcutaneous or sub mucosal tissues, representing
localized edema caused by dilation and increased
permeability of the capillaries.
Definition of angioedema

8. Types of Angioedema
Types:
Idiopathic
angioedema
Drug-induced
angioedema
Allergic
angioedema
Hereditary
angioedema

9. Pathophysiology of angioedema
• ACE-inhibitor associated angioedema: inhibitor of
breakdown of bradykinin
• Allergic angioedema: IgE mediated degranulation of
mast cells.
• Hereditary angioedema: deficiency in C1 esterase
inhibitor, with resulting increased local bradykinin
concentration.

10. Pathophysiology of allergic angioedema

11. Pathophysiology of allergic angioedema cont…

12. • Foods.
• Medications.
• Common allergens.
• Environmental factors.
• Underlying medical conditions.
• Genetics.
Causes and risk factors of angioedema

13. • Have other allergic reactions like:
• Asthma
• Eczema
• Hives
• Drinking alcohol
• Taking NSAIDs drugs
• Emotional stress
Causes and risk factors of angioedema cont…

14. Signs and symptoms of angioedma
Swelling Itching
Pain in the area
Difficult breathing
Redness

15. Quiz
• The swelling of angioedema usually affect the:

16. Difference between angioedema and urticaria
UrticariaAngioedema
Transient erythematous swelling of
the superficial dermis, associated
with itching, which usually resolves
within 24 hours.
Characterized by swellings in the
deeper dermal layer.

17. Diagnosis of angioedema
• Blood tests
• Prick test

18. Complication of angioedema
.
Airway Blockage
Loss of consciousness
Anaphylactic shock

19. Treatment
corticosteroids
Inhaler medicinesAntihistamines
Epinephrine shots

20. Treatment
Non- medication treatment(prevention)

21. Quiz
• How many type of angioedema:
3
6
4
Types:
Idiopathic
angioedema
Drug-induced
angioedema
Allergic
Angioedema
Hereditary
angioedema

22. Summary of angioedema
Trigger- infection, inhalation

23. References

24. Questions? 

25. THANK YOU