This document discusses various developmental disturbances that can occur in the tongue, including microglossia, macroglossia, ankyloglossia, cleft tongue, fissured tongue, median rhomboid glossitis, benign migratory glossitis, hairy tongue, lingual varices, and lingual thyroid nodule. It provides details on the etiology, clinical features, classification where relevant, and treatment for each of these conditions. Various tongue abnormalities can result in difficulties with speech, swallowing, or irritation and infection if debris gets trapped. Treatment may involve surgery, antifungal medications, or reducing long term antibiotic use depending on the specific condition.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
DEVELOPMENTAL DISTURBANCES OF LIPS & PALATE / dental implant coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Morphologically altered tissue in which cancer is more likely to occur than its apparently normal counter part.
-WHO(1978)
Definition
Leukoplakia is defined as ‘white patch’ or ‘plaque’ in the oral cavity, which cannot be scraped off or stripped off easily and more over which cannot be charectarized clinically or pathologically as any other disease. –WHO
Redefined as a “ predominantly white lesion of oral mucosa that cannot be characterized as any other definable lesion; some oral leukoplakia will transform into cancer” (Axell T, 1996)
Homogenous Leukoplakia
Non-Homogenous Leukoplakia
Granular or Nodular Leukoplakia
Speckled or Erythroleukoplakia
Verruciform Leukoplakia
Proliferative Verrucous Leukoplakia
DEVELOPMENTAL DISTURBANCES OF LIPS & PALATE / dental implant coursesIndian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
Morphologically altered tissue in which cancer is more likely to occur than its apparently normal counter part.
-WHO(1978)
Definition
Leukoplakia is defined as ‘white patch’ or ‘plaque’ in the oral cavity, which cannot be scraped off or stripped off easily and more over which cannot be charectarized clinically or pathologically as any other disease. –WHO
Redefined as a “ predominantly white lesion of oral mucosa that cannot be characterized as any other definable lesion; some oral leukoplakia will transform into cancer” (Axell T, 1996)
Homogenous Leukoplakia
Non-Homogenous Leukoplakia
Granular or Nodular Leukoplakia
Speckled or Erythroleukoplakia
Verruciform Leukoplakia
Proliferative Verrucous Leukoplakia
for undergraduate dental students this presentation includes essential & common disorders which related to the tongue very briefly. Though this may be very helpfull to you to as a start for further readings & studying.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. Anterior two-third: From two lingual
swellings and one tuberculum impar, which
arises from the first branchial arch. The
tuberculum impar soon disappears.
Posterior one-third: From cranial large part of
the hypobranchial eminence, ie. from the
third arch
Posteriormost part from the fourth arch
DEVELOPMENT OF TONGUE
4. MICROGLOSSIA
It is a rare congenital anomaly manifested by
the presence of Rudimentary or small tongue
The condition when tongue being completely
absent is known as aglossia
Patient finds difficulties in eating and
swallowing
7. MACROGLOSSIA
It is a condition when patient have an
enlarged tongue
May be congenital or acquired
ETIOLOGY FOR CONGENITAL
MACROGLOSSIA
Congenital macroglossia is due to an over
development of the musculature
Down syndrome
Beckwith-Wiedemann syndrome
8. CAUSES FOR ACQUIRED MACROGLOSSIA
1. tumors in tongue such as
lymphangioma,hemagioma and
neurofibroma
2. Acromegaly
3. Mxedema
4. Amyloidosis
5. Angioedema
12. ANKYLOGLOSSIA
It can be defined as a developmental
condition characterized by fixation of tongue
to the floor of the mouth,causing restricted
movement
It can be either complete ankylogssia or
partial ankyloglossia (tongue tie)
13. Partial ankyloglossia occurs as a result of
shortlingual frenum or due to a frenum which
attaches too near to the tip of the tongue
Complete ankyloglossia occurs as a result of
fusion between the tongue and the floor of the
mouth
14. 14
CLINICAL FEATURES
speech disorders
deformities in dental occlusion
Difficulties in swallowing
TREATMENT
Partial ankyloglossia are self corrective
Complete ankyloglossia can be surgically
treated by frenulectomy
16. CLEFT TONGUE
A complete cleft tongue occurs due to lack of
merging of lateral lingual swellings of this
organ
partially cleft tongue occurs more common
and is manifested as deep groove in the
midline of dorsal surface
Partial cleft tongue occurs due to incomplete
merging and failure of groove obliteration by
underlying mesenchymal prolifetation
food debris and microorganisms collect in
base of cleft and cause irritation
18. FISSURED TONGUE
Its a malformation manifested clinically by
numerous small grooves on dorsal surface
radiationg out from central groove along the
midline of tongue
ETIOLOGY
It also occurs as a sequel to geographic
tongue
Hereditary factors
20. The lesions are ususally asymptomatic
unless debris is entrapped within the fissure
and causes irritation
Fissured tongue affects the dorsum surface
and often extends to the lateral bordres of
the tongue and form lobules
22. MEDIAN RHOMBOID GLOSSITIS
Synonyms- central paillary atrophy of the
tongue / posterior lingual papillary atrophy
It is an asymptomatic elongated
erythematous patch of artophic mucosa on
the middorsal surface of the tongue
23. ETIOLOGY
It has been described as a congenital
abnormality of tongue due to failure of
tuberculum impar to retract before fusion of
lateral halves of tongue so that structure
devoid of papillae is interpose between them
It is a focal area of susceptibility to chronic
infections by candida albicans
23
24. CLINICAL FEATURES
Lesion appears Ovoid, diamond rhomboid
shaped reddish patch on dorsal surface of
tongue immediately anterior to
circumvallate papillae.
it appears as a flat or slightyly elevated area
and stands out distinctly from rest of tongue
because it has no filliform papillae
Seen mostly in females in a ratio 3:1 when
compared with males
Kissing lesions are seen.
27. BENIGN MIGRATORY GLOSSITIS
Synonyms-georgaphic tongue,erythema
migrans and wandering rash of tongue
ETIOLOGY
The exact etiology remains unknown. It may
be genetic.
However many investigators believe that
emotional stress may precipitate this
condition
28. CLINICAL FEATURES
The lesion occurs in about 1 to 3 % of population
Females are affected more frequently than males by a
2:1 ratio
Geographic tongue is usually seen on the anterior
two third of the dorsal tongue mucosa
the condition is characterized by multiple, well-
demarcated, erythematous, depapillated patches,
typically surrounded by a slightly elevated yellow
white scalloped border, and usually restricted to the
dorsumof the tongue
30. TREATMENT AND PROGNOSIS
there is no specific treatment for erythem
migrans
heavy doses of vitamins and and topical
steroids may produce someresutls in few
cases
31. HAIRY TONGUE
SYNONYMS- BLACK HAIRY TONGUE, LINGUA
NIGRA, LINGUA VILLOSA
Hairy tongue is characterized by marked
accumilation of keratin on filliform
papillae of the dorsal surface resulting in a
hair like appearence
32. ETIOLOGY
Chronic smokers
It occurs due to microorganisms such as
candida albicans
Systemic disturbances like anemia,gastric
upset
Oral use of certain drugs like sodium
perborate sodium peroxide and antibiotics
such as penicillin
Extensive x-ray radiation
33. CLINICAL FEATURES
formation of a pigmented thick matted layer
on the tongue surface heavily coated with
bacteria and fungi
Hair like appearence
Halitosis
Irritation of tongue due to accumulation of
food debris
Candidal over growth may cause
glossopyrosis( burning tongue)
36. LINGUAL VARICES
It is a dilated , tortous vein which is often subjected
to increased hydrostatic pressure but is poorly
supported by surrouonding tissue
37. CLINICAL FEATURES
Varices usually involves the lingual ranine viens
the involved veins appears red of purple shotlike clusters of
vessels on the ventral surface and lateral borders of tongue
as well as in the floor of the mouth
Presence of lingual varices before the ages of 50 indicates
premature ageing
Treatment
There is no specific treatment for lingual varices
39. LINGUAL THYROID
NODULE
it is an anomalous condition in which
follicles of thyroid tissue are found in the
substance of the tongue
ETIOLOGY
It occurs when thyroid anlage that failed to
migrate to its predestined position or from
anlage remnants that became detached and
were left behind
40. CLINICAL FEATURES
It appears as a nodular mass in or near the base
of tongue just posterior to foramen caecum
Deeply situated and have a smooth surface
The size varies from 2 – 3 cm
Chief symptoms are dysphagia, dyspnea,
dysphonia or fullnes of throat