In this pppt I have described surgical anatomy of chest wall, lungs and mediastinum. This will be useful to medical students, surgical residents and surgons
• Gross anatomy:
– Components of the lymphatic system: lymphatic plexuses, lymphatics, lymphoid tissue
– Plan of the lymphatic system: Superficial lymphatic vessels, deep lymphatic vessels, lymph nodes, lymph trunks, cysterna chyli, lymph ducts: right lymph duct and thoracic duct.
– Lymphatic drainage of the lower limb
• Superficial inguinal lymph nodes: arrangement and drainage area.
• Deep inguinal lymph nodes: arrangement and drainage area. The popliteal lymph nodes
– Lymphatic drainage of the upper limb
• Superficial and deep lymphatics. Supratrochlear and infraclavicular lymph nodes.
• Axillary lymph nodes: arrangement and drainage area.
– Plan of the lymphatic drainage of the head and neck: deep cervical lymph nodes, inner and outer circle of lymph nodes.
• Deep cervical lymph nodes: location of the upper and lower groups, jugulodigastric node, jugulo-omohyoid, supraclavicular lymph nodes. Drainage area and efferent vessels.
• The outer circle of lymph nodes: submental, submandibular, buccal, mandibular, parotid, mastoid, occipital: location, drainage area and efferent vessels.
• The inner circle of lymph nodes: pretracheal, paratracheal and retropharyndeal.
• The tonsils and Waldeyer’s ring.
– Lymphatic drainage of the thorax:
• Lymph nodes of the chest wall: Parasternal, intercostal, and phrenic
• Lymph nodes of the mediastinum: Nodes around the division of the trachea and the main bronchi, anterior and posterior mediastinal nodes.
– Plan of lymphatic drainage of the abdomen: lumbar and intestinal lymph trunks.
• Pre-aortic lymph nodes: mesenteric, celiac, superior and inferior mesenteric lymph nodes.
• Para-aortic lymph nodes.
• MALT & Peyer’s patches.
– Lymphatic drainage in the pelvis: External and internal iliac lymph nodes, lymph nodes in fascial sheaths, sacral and common iliac lymph nodes.
• Applied anatomy
• Functional and clinical importance of the lymphatic system; Virchow’s lymph nodes; Retropharyngeal abscess; Clinical applications of enlarged thoracic lymph nodes: involvement of left recurrent laryngeal nerve and phrenic nerve. Pressure on the esophagus. Carinal lymph nodes and bronchoscopy; Communications of lymphatics between thorax and abdomen.
• Radiographic anatomy:
– Lymphangiogrms.
• Surface anatomy of palpable lymph node groups: superficial inguinal, axillary, infraclavicular, outer circle of crevical lymph nodes, deep cervical lymph nodes.
• Gross anatomy:
– Components of the lymphatic system: lymphatic plexuses, lymphatics, lymphoid tissue
– Plan of the lymphatic system: Superficial lymphatic vessels, deep lymphatic vessels, lymph nodes, lymph trunks, cysterna chyli, lymph ducts: right lymph duct and thoracic duct.
– Lymphatic drainage of the lower limb
• Superficial inguinal lymph nodes: arrangement and drainage area.
• Deep inguinal lymph nodes: arrangement and drainage area. The popliteal lymph nodes
– Lymphatic drainage of the upper limb
• Superficial and deep lymphatics. Supratrochlear and infraclavicular lymph nodes.
• Axillary lymph nodes: arrangement and drainage area.
– Plan of the lymphatic drainage of the head and neck: deep cervical lymph nodes, inner and outer circle of lymph nodes.
• Deep cervical lymph nodes: location of the upper and lower groups, jugulodigastric node, jugulo-omohyoid, supraclavicular lymph nodes. Drainage area and efferent vessels.
• The outer circle of lymph nodes: submental, submandibular, buccal, mandibular, parotid, mastoid, occipital: location, drainage area and efferent vessels.
• The inner circle of lymph nodes: pretracheal, paratracheal and retropharyndeal.
• The tonsils and Waldeyer’s ring.
– Lymphatic drainage of the thorax:
• Lymph nodes of the chest wall: Parasternal, intercostal, and phrenic
• Lymph nodes of the mediastinum: Nodes around the division of the trachea and the main bronchi, anterior and posterior mediastinal nodes.
– Plan of lymphatic drainage of the abdomen: lumbar and intestinal lymph trunks.
• Pre-aortic lymph nodes: mesenteric, celiac, superior and inferior mesenteric lymph nodes.
• Para-aortic lymph nodes.
• MALT & Peyer’s patches.
– Lymphatic drainage in the pelvis: External and internal iliac lymph nodes, lymph nodes in fascial sheaths, sacral and common iliac lymph nodes.
• Applied anatomy
• Functional and clinical importance of the lymphatic system; Virchow’s lymph nodes; Retropharyngeal abscess; Clinical applications of enlarged thoracic lymph nodes: involvement of left recurrent laryngeal nerve and phrenic nerve. Pressure on the esophagus. Carinal lymph nodes and bronchoscopy; Communications of lymphatics between thorax and abdomen.
• Radiographic anatomy:
– Lymphangiogrms.
• Surface anatomy of palpable lymph node groups: superficial inguinal, axillary, infraclavicular, outer circle of crevical lymph nodes, deep cervical lymph nodes.
Chest injuries ranks 3rd after head injuries and extremity injuries in a case of multisystem trauma.It is of two types blunt chest trauma and peneterating chest trauma.The main cause of blunt chest trauma is road side accidents due to vehicles. Peneterating chest trauma is more dangerous and is common in war injuries and civilian terroism.In this ppp I have discussed some useful uncommon and important aspects of chest injuries
Amputation is one of the meanest yet one of the greatest operations in surgery,i.e. mean- when resorted to where better may be done, Great – as the only step to give comfort to patient and prolong his lhis. This was said by Sir William Ferguson Great British Surgon of 19th century. In this ppp I have described tt in a simple and lucid way
Lymphoedema is an abnormal swelling of limb due to the collection of excessive amount of high protein fluid secondary to defective lymphatic drainage in the presence of normal capillary filteration.It is very disabiling condition to the patient. In this ppp I have discussed its clinical picture and management in a simple way
Carcinoma esophagus is a lethal disease and carries poor prognosis.The diagnosis is usually delayed and over all 5yrs survival is less than 15% In this presentation I have discussed carcinoma esophagus - its pathology, clinical features, investigations and treatment in nutshell
In this ppp I have described three new original thoracic surgical operations which I have devised myself, used for many years and published in reputed international journals.These are very useful and simple operatins for complex chest problems and will benefit every thoracic surgon for treating his patients
This is prestigious Godrej S Karai Oration I delivered in the annual conference of IACVTS -Indian Association of Cardiovascular & Thoracic Surgons few years back.Thoracic Surgery is neglected cousin of Cardiac Surgery in India but it is equally important for patients and students.I hope this ppp will stimulate the minds of younger CVT Surgons .
Valular heart disease is very common in most of Afro Asian counteries mainly due to Rheumatic heart disease..Definitive treatment is surgery.which may be valve replacement or reapir. In this ppp I have discussed this subject in a simple way
Swallowing of any foregion body like coins, pins,seeds,buttton batteries and platic pieces is common in children.In older persons pieces of bone (fish or chicken) or part of loose denture is common. It becomes an emergency situation and needs urgent treatment.In this ppp I have discussed this problem in a brief and clear way
Pulmonary tuberculosis is a very common disease in developing counteries and a big health hazard. Drug therapy is main treatment.Surgery is required mainly for its complications.In this ppp I have described this topic in a simple way
This is an Original Life Saving Surgical technique developed and published by me for treatment of Masiive or Recurrent Hemoptysis where standard lung resection is technically very difficult and or hazardous
Power point presentation about general principles of organ transplantation and pioneer surgons and investigators, Specific discussion about Heart, Heart lung and Lung transplantation is given
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
1. Anatomy of Chest wall,Lungs and
Mediastinum
Dr R S Dhaliwal
MBBS,MS,DNB(Surgery),M.Ch,DNB(CTVSurgery),
FACS,FCCP,FICA,FNCCP,FIACS
Prof. of CTV Surgery, UCMS
Former, Prof & HOD, CTV Surgery,
PGIMER,Chandigarh
2. Chest wall
• The thorax is upper part of trunk bounded by 12
ribs, vertebrae and sternum.It contains trachea ,
two lungs , heart and great vessels, esophagus
and lymph nodes.
• There are two thoracic apertures or openings .
Superior thoracic aperture also called as thoracic
inlet and inferior thoracic aperture . Head and
neck and upper limbs communicate with thoracic
cavity through thoracic inlet .It is bounded by
body of first thoracic vertebra, Inferior thoracic
aperture opens into peritoneal cavity
4. Inferior thoracic aperture
The posterior aspect of the thorax. (Inferior thoracic aperture
visible at bottom.)
Latin apertura thoracis inferior
[
5. Chest wall
• Skelton- The bony framework is bounded by the 12 thoracic
vertebrae postly, from which 12 sets of bony ribs articulate
and curve around, connecting with the manubrium, sternum,
and costal cartilage anteriorly
• The central anterior chest is defined by the sternum, which
consists of 3 separate bones , manubrium first,then sternal
body, and then xiphoid process. These are flat polygonal
bones .The manubrium is located at the level of the T3 and
T4 vertebra and is widest and thickest of 3 sternal bones. A
palpable landmark on manubrium is jugular or suprasternal
notch, which is bounded on either side by the medial ends
of the clavicles. The sterno manubrial junction(Angle of
Louis ) is projected . The body of sternum is located at the
level of T5-T9 vertebrae. The xiphoid process is the smallest
and thinnest bone. It often has a point, it can be blunt, bifid,
or curved. The xiphoid is cartilaginous in younger people but
is nearly ossified by age 40.
6. Chest wall
• The first 7 ribs, called true ribs, are attached to the sternum
and manubrium directly. The 8th-10th ribs called False ribs
are attached via the costal cartilages, while the 11th and
12th ribs remain unattached anteriorly. The 8th-10th ribs are
known as false ribs because they lack direct attachment to
the sternum, and the 11th-12th are referred to as floating
ribs. Posteriorly, the ribs articulate with costal facets of 2
adjacent vertebrae. An articular capsule surrounds the head
of each rib, which is secured by attachments of the radiate
ligament. Each rib also articulates with the transverse
process of its adjacent vertebrae through a costotransverse
joint. The bony ribs then curve around anteriorly, where the
next major junction is the costochondral joint.
8. Chest wall
• There are hyaline cartilage joints, and the rib and
cartilage are firmly attached through the
continuity of overlying periosteum and
perichondrium. The ribs/costal cartilages have
various attachments to the sternum. The first
pair of ribs articulates through cartilaginous
joints or synchondroses and is relatively
immobile. The second through seventh pairs of
costal cartilages articulate with the sternum at
synovial joints that move during respiration.
These articular capsules are reinforced by
sternocostal ligaments. This bony architecture
provides attachments for muscles to the neck,
thorax, upper limbs, abdomen, and back.
14. Pleura
• The pleural cavity is the potential space between the two pleura (visceral
and parietal) of the lungs. The pleura is a serous membrane which folds
back onto itself to form a two-layered membrane structure. The thin
space between the two pleural layers is known as the pleural cavity and
normally contains a small amount of pleural fluid. The outer pleura
(parietal pleura) is attached to the chest wall. The inner pleura (visceral
pleura) covers the lungs and adjoining structures, via blood vessels,
bronchi and nerves.
• The parietal pleura is highly sensitive to pain, while the visceral pleura is
not, due to its lack of sensory innervation
• In humans, there is no anatomical connection between the left and right
pleural cavities. Therefore, in cases of pneumothorax, the other lung will
still function normally unless there is a tension pneumothorax or
simultaneous bilateral pneumothorax, which may collapse the
contralateral parenchyma, blood vessels and bronchi.
• The pleural cavity, with its associated pleurae, aids optimal functioning
of the lungs during respiration. The pleural cavity also contains pleural
fluid, which allows the pleurae to slide effortlessly against each other
during ventilation. Surface tension of the pleural fluid also leads to close
apposition of the lung surfaces with the chest wall.
18. Lungs
• Two lungs – Right and
Left .Right bigger in size
• -3 Lobes in right lung –
Upper, Middle, Lower
.2 Lobes in left lung
- Upper and Lower
Upper divided into
Upper and Lingula
24. Mediastinum
• It is space in thorax located between thoracic
inlet superiorly, inferiorly by diaphragm, antly by
sternum , postly by spine and laterally by pleural
spaces
• Classically it is divided into four compartments
superior,anterior,middle and posterior. Another
popular division is into three parts –
Anterosuperior, middle and posterior
• Shields classified into three compartments-
Anterior, Middle or visceral and Posterior or para
ventral sulcus