Pathogens first must cross physical and chemical barriers before potentially infecting cells. Microbial pathogens express PAMPs that are recognized by PRRs on sentinel cells like macrophages and dendritic cells. Macrophages become activated and have two subtypes - M1 which are killer cells and M2 which aid tissue repair. Antigen presenting cells display antigens using MHC molecules and travel to lymph nodes to activate T cells. Activated T cells differentiate into effector T cells that coordinate the immune response and memory T cells that remain inactive until future infection. B cells encounter antigens, become activated and undergo proliferation and somatic hypermutation in germinal centers, then differentiate into memory B cells or plasma cells that secrete antibodies.
T-cells is explained with a emphasis with humoral and adaptive immunity . And the diffrent subsets of t cells are well explained by Dr Harshavardhan Patwal here .
This presentation gives you the detailed description of various cells & organs of immune systems that participates (particularly, in combination), make communication between themselves to regulate the whole immune system very precisely.
T-cells is explained with a emphasis with humoral and adaptive immunity . And the diffrent subsets of t cells are well explained by Dr Harshavardhan Patwal here .
This presentation gives you the detailed description of various cells & organs of immune systems that participates (particularly, in combination), make communication between themselves to regulate the whole immune system very precisely.
Histology of group of immune cells that mediate the cellular immune response by processing and presenting antigens for recognition by certain lymphocytes such as T cells.
The main effector cells of innate immunity are macrophages, neutrophils, dendritic cells, and natural killer (NK) cells .
Phagocytosis, release of inflammatory mediators, activation of complement system proteins, as well as synthesis of acute phase proteins, cytokines and chemokines are the main mechanisms in innate immunity
Immune system and its functions
The main effector cells of innate immunity are macrophages, neutrophils, dendritic cells, and natural killer (NK) cells .
Describes the basic properties and mechanisms of T cells and B cells in maintaining Immune Response against foreign antigens or infections and covers the UG and PG portion of immunology.
T cells are one of the important white blood cells of the immune system and play a central role in the adaptive immune response and are distinguished from other lymphocytes by the presence of a T-cell receptor (TCR) on their cell surface.
B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. They function in the humoral immunity component of the adaptive immune system.. B cells produce antibody molecules.
In mammals, B cells mature in the bone marrow, which is at the core of most bones. In birds, B cells mature in the bursa of Fabricus.
B cells present antigens (they are also classified as professional antigen-presenting cells (APCs)) and secrete cytokines.
By DR. MANPREET KAUR BEHL.
Description of classificaton of immune system, immune cells, HLA, MHC complexes, antigen presentation, t-cell responses and b-cell responses, antibody, isotype switching, hypersenstivity reactions etc.
Phagocytosis begins with adhesion of the phagocyte surface receptors to the pathogen, which then is internalized into vesicles called phagosomes.
Inside the phagocyte, the phagosome fuses to lysosomes, whose contents are released with consequent digestion and pathogen elimination.
Changes in the oxidase’s gene system components present in phagolysosome membrane lead to disability in respiratory burst and generation of reactive oxygen species (ROS).
Phagocytosis begins with adhesion of the phagocyte surface receptors to the pathogen, which then is internalized into vesicles called phagosomes.
Inside the phagocyte, the phagosome fuses to lysosomes, whose contents are released with consequent digestion and pathogen elimination.
Changes in the oxidase’s gene system components present in phagolysosome membrane lead to disability in respiratory burst and generation of reactive oxygen species (ROS).
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
An integrated and brief overview of the function of human immune system
1. First Pathogen must cross the physical barriers (e.g.: skin, stomach and vagina; all has an acidic pH) and chemical barrier (e.g.: sweat, mucus, tears, and saliva; all
contain enzymes that kill pathogens). Once pathogens cross all those barrier, they may go to blood circulation, reside at intracellular space or infect cells/tissues.
Microbial pathogens express PAMP (Pathogen associated
molecular patter) and Necrotic/dying cells produce DAMP
(Danger associated molecular pattern). PAMP include LPS
(pipopolysaccharide), PGN (peptidoglycan), bacterial DNA, viral
dsRNA etc. PAMP is recognized by PRR (Pattern recognition
receptor) on the sentinel cells (body’s first line of defense cells),
such as: Macrophage Dendritic cell , Mast cell
Macrophage (specialized monocyte) in tissue becomes
activated by various factor. Macrophage can present antigen
and produce cytokine. It has different names based on
location (Kupffer cells - in the liver, Langerhans cells - in the
skin and mucosa, Alveolar macrophages - in the lungs,
Microglia – in the brain). It has mainly 2 subtype for function:
M1 (Killer type, activated by LPS & IFNγ, release IL-12),
M2 (Tissue Repair, elevated by IL-4, produce IL-10 & TGFβ )
Already infected cells secrete Type-I interferons (eg- IFNα and IFNβ which interfere
with viral replication), and also cause down regulation of MHC-I molecules.
Antigen Presenting Cells like- Macrophage (Mφ), Neutrophil
or Dendritic cell (DC) displays antigen. APC displays antigen
using MHC Class I or Class II molecule. DC can be of 2 type
(myeloid DC & plasmacytoid DC). APC travels to lymph node.
Activated macrophage cause production of inflammatory
cytokines (eg. IL-1, IL-6, IL-12, TNF, CXCL8). A chemokine,
CXCLB, causes a conformational change in the
ICAM/integrin adhesion, trigger activation of Integrin.
Granulated Basophil cells (circulate) and Mast cells
(resident in tissues) discharge their granules
releasing Heparin and Histamin to reduce blood
viscosity and encourage vasodilation. This increases
blood flow and therefore flow of leucocytes to the
area of infection (Inflammatory response).
T helper cell (Th) binds with MHC II on APC and upregulates
expression of CD40L (activation). CD40L binds with CD40 on APC,
leading to more expression of MHC & greater activation of Th cell.
Cytokines are broad category of small proteins that are
important in cell signaling. Cytokines may include
chemokines, interferons, interleukins, lymphokines, and tumor
necrosis factors; but generally not hormones or growth factors.
Other effects of cytokines involve: Activation of Complement
system, cause Fever and Vasodilation.
Endothelial cells overexpress P and E-selectin, ICAM-1 etc; and
bind to integrins (e.g. LFA-1) on the neutrophils. Neutrophils
squeeze between neighboring endothelial cells and cross the
basement membrane by secreting proteases to break it down.
NK cell also release granules containing Perforin and Granzymes. Perforin
perforates membrane of target cell & Granzymes enter, induce apoptosis
Prostaglandins convert into Prostacyclin which inhibits platelet activation and acts
as an effective vasodilator. Prostaglandins can also synthesize Thromboxane
which play role as platelet aggregation.
Recognition of ‘missing self’ by Natural Killer cell, activate them, secrete
Type II interferon (eg- IFNγ, which play role in activation of Macrophage )
Infection along with other stress cause cell membrane injury, which activate
Platelet activating factor found in the lipid bilayer. Arachidonic acids in
Phospholipid bilayer converted into Prostaglandins (by cyclooxygenase enzyme)
and Leukotriene (by Lipooxygenase enzyme)
Mast cell activation also attracts Eosinophils
which combat parasitic worms (if present) and
neutralize/ control inflammatory response
Complement system: It can start in three way-
i) Classical pathway (immune complex)
ii) Lectin pathway (microbes, mannose)
iii) Alternative pathway (spontaneous, microbes)
Molecules that play role in the complement cascade are:
Classical (C1q,C1r, C1s, C2, C4 ), Lectin (MBL, MASP, C2, C4),
Alternative (C3b, factor B, factor D), C3 (C3a, C3b), C5 (C5a, C5b)
Finally, C5b C6 C7 & C9 together form a membrane attack
complex, then target cell swells and bursts
Histamin acts on vascular walls of smooth
muscle cell, cause vasodilation that leads
to heat and redness. Histamin receptors
on nerve ending lead to pain (Dolor).
Histamin on blood vessel endothelium cause
overexpression of P-selectin and Shrinking of
endothelial cells, which leads to increase in
vascular permeability.
Both increased vascular permeability &
vasodilation leads to movement of proteins and
leukocytes from blood into tissue fluid space.
Cytotoxic T cell (Tc) binds with MHC I on Dendritic cell and
upregulates expression of CD40L, which binds with CD40 on APC,
leading to greater expression of MHCI & activation of Tc cell.
Infected cell displays fragments of virus on surface using
MHC class I molecules. Tc cells identifies, activates and
destroys infected cells by apoptosis. Tc cells also support NK T
lymphocytes to destroy early cancers.
It results formation of inflammatory Exudate, which
leads to Swelling (Tumor) and Pain.
Also happen Chemotaxis ie, all leukocytes are
stimulated to migrate towards the infected area.
Activated T cells (CD25) then mature
into two types of T cell: i) Effector T
cell: Coordinate immune response, by
becoming helper or cytotoxic T cell
ii) Memory T cell: Remain inactive
until future infection. Its subtypes
are- Central MT (CD45RO, CCR7
CD44), Effector MT (CD45RO, CD44),
Tissue Resident MT, & Virtual MT
T cells are produced in bone
marrow (Stem cell, CD34) and
travel to thymus for maturation.
There they meet Antigens.
After naïve T cell (CD45RA)
encounters an antigen it becomes
activated and begins to proliferate.
T cells which fail to bind with MHC
or have an over affinity for MHC &
self-antigen undergo negative
selection. Those T cell that can bind
with self-MHC, survive.
Activated Tc cells create a large clone of cell-surface receptors
(called TCR) which are specific to antigens. Tc cells leave lymph
node and travels to area of infection.
Th cells coordinate immune response by stimulating response of
other cells including B cells. Th cell subtype and functions are:
i) Th1 (Activated by IL-12; produce IFNγ, IL-2 & TNFα; Acts on
intracellular pathogen, Cell mediated immunity and inflammation)
ii) Th2 (Activated by IL-4; Produce IL-4, IL-5, IL-6, IL-10 & IL-13; Acts
on Antibody mediated immunity, Allergic response)
iii) Th17 (Activated by TGFβ, IL-6, IL-23; Produce IL-17, IL-21, IL-22;
Fights fungal infections, Extracellular bacteria, Autoimmunity)
iv) Regulatory T cell (Activated by TGFβ, IL-12; Produce TGFβ, IL-10,
IL-35; Prevents overactive immune response)
v) Follicular helper T cell (Tfh) (Trigger the formation of Germinal
Centers by expressing CD40 Ligand & by the secretion of IL-21, IL-4)
Immature B cell leaves bone marrow
and circulates through blood and
lymphoid tissue. As it leaves bone
marrow it begins displaying IgD as
well as IgM on surface.
Surviving Centrocytes progress to Apical light
zone and present an antigen via MHC II to Th
cells. Those that are recognized receive signal to
differentiate into two type of cells:
Memory B cell (detector, keeps sp. memory)
& Plasma cells (Antibody production house)
Activated B cells travel to dark zone of germinal
centers in secondary follicles, express less Ig and
undergo Clonal Expansion (proliferation) and
Somatic hypermutation (expression of varying
affinity Ig). Now the cells are known as
centroblasts.
Antibodies secreted by plasma
cells bind with respective
antigens or pathogens; opsonize
pathogen , or neutralize viruses.
Centroblasts proceed to
Basal Light zone and
become Centrocytes. Here
they are exposed to antigen
presented by FDCs. Those
with low affinity to antigen
are destroyed.
Every plasma cell is essentially a factory for
producing an antibody. Each of the plasma cells
manufactures millions of identical antibody
molecules and pours them into the bloodstream.
During proliferation B cells can also switch classes, if
stimulated by a cytokine, by changing Fc region.
The immunoglobulin superfamily (IgSF) is a
large group of cell surface and soluble
proteins that are involved in the recognition,
binding, or adhesion processes. The Fc part of
antibodies help to bind with different
receptors and perform different functions.
Immature B cell created from Stem
Cell in Bone Marrow (displays IgM
on surface, also contain CD34 as
distinctive marker)
Now a Naïve (aka virgin) B cell in primary follicles of
lymph nodes endocytoses and presents antigen. The
interaction of antigens with membrane antibodies on
naive B cells initiates B cell activation. They becomes
2nd signal from conjugate Th1 cell.
(B cells that do not bind to antigen die in 1 week)
Edited by: Hasan Al Banna immunitybd.wordpress.com
An integrated and brief overview of the HUMAN IMMUNE SYSTEM
Stimulation of TLR (Toll like receptor) by corresponding PAMP or DAMP
initiate signaling cascade leading to activation of transcription factors,
like- AP-1, NFκB, IRF. TLR subtypes (& associated PAMP)are:
TLR1 (LPS, PGN, Triacylated lipoprotein), TLR2 + TLR6 (Diacylated
lipoprotein), TLR3 (dsRNA, tRNA, siRNA), TLR4 (LPS, paclitaxel), TLR5
(Flagelin), TLR7 (ssRNA, Imidazoquinolon, Guanosin analog), TLR8
(ssRNA, Imidazoquinolin), TLR9 (CpG DNA, CpG ODNs), TLR10 (profilin-
like protein). Monocyte, Mφ and DC express TLR(1, 2,4,5,6,7,8,9,10), B
cell express TLR(1,2,6,7,9), T cell contain TLR(3,9), Mast cell has TLR(4,
8), NK cell has TLR3, Intestinal Epithelium express TLR(4,5)
Effector T cells are transported via blood vessels
to the lymph nodes and spleen & become
specialized. They bind with Class I or Class II MHC
present on the surface of Antigen-presenting cells
(APCs) in the Lymph node. Lymph gathers antigens
as it drains from tissues, are filtered through lymph
nodes, & captured by APCs. The spleen also houses
B and T cells, macrophages, dendritic cells, and NK
cells. The spleen is also the site where APCs can
communicate with lymphocytes.
Distinctive CD markers in some CD45+ve cells: T lymphocyte (CD3), Th cell (CD4),
Tc cell (CD8), Granulocyte (CD15), Monocyte (CD14), B cell (CD19), Treg (CD4,
CD25, FOXP3), Tfh (CD4, CXCR5), Thrombocyte (CD61), NK cell (CD56, CD16),
NKT(CD4, CD8, CD56, CD161)
Immunoglobulin types and function:
IgG (75-85%): secreted by Plasma cell, can cross placenta in fetus, can
activate phagocytosis, neutralizes antigen.
IgM (5-10%): First antibody produced in initial immune response,
activates complement, pentamar in structure.
IgA (10-15%): Found in mucous, saliva, tears and breast milk. Protects
against pathogen in entry points.
IgD (0.001%): Part of B cell receptor & trigger its activation. Activate
basophils & mast cells
IgE (0.002%): Remain as bound to the surface of mast cell and
basophils, responsible for allergic reactions, protect against parasites
Interleukin types and function:
IL-1: source Macrophage; cause activation of Th and B cell
IL-2: source Th1 cell; cause proliferation & activation of NK, Tc
IL-3: Th Tc & NK; proliferation of Hematopoietic & Mast cells
IL-4: Th2 Mast & NK cell; cause B cell class switch, inhibit Mφ
IL-5: source Th2 Mast cell; proliferation of Eosinophil
IL-6: source Mφ Th2; acts on B cell, Ab produced by Plasma cell
IL-8: Bone marrow Thymus; acts Neutrophils, Chemoattractant
IL-9: sourceTh2 cell; survival of Treg, accumulation of Mast cell
IL-10: Th2 cell; activate B cell, help APC, inhibit Mφ function
IL-12: Mφ, mDC & B cell; cause proliferation of Tc, NK cells
IL-13: Th cell; acts Mφ & B cell for regulation of inflammation
IL-17: Th17; activate of innate immunity, pro-inflammation
IL-22: source Th17; regulate autoantibody production
B cell development and corresponding CD Markers:
Stem cell (CD34) > Pro B cell (CD34, CD19) > Pre B cell (CD19, CD20) > Immature B cell (CD19, CD20,
IgM) > Naïve B cell (CD19, CD20, CD38) > GC B cell (CD19, CD20, CD38, IgM, IgD) > Memory B cell
(CD19, CD20, CD27, IgA, IgG, IgE) > Plasmablast (CD19, CD27, CD38) > Plasma cell (CD27, CD38, CD138)
If Plasma cell are triggered by Th2 and
produced against Allergen (displayed by APC to
Th2), they secrete IgE. IgE binds to Mast cells.
Mast cell release inflammatory molecules,
resulting in allergic response.