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ALCEO Solid Target Presentation at SNMMI Annual Meeting 2018
ALCEO Solid Target Presentation at SNMMI Annual Meeting 2018
64Cu 89Zr 203Pb
ALCEO METAL ALCEO HALOGEN
123/124I68Ga 45Ti 44Sc
PTS & COOLING SYSTEM
EDS 3.0
TADDEO
GE PETtrace - Not shielded cyclotron
GE PETtrace - Self shielded cyclotron Generic external beam line
IBA Cyclone or Kiube cyclotron
• Installed outside the bunker
• Cools down the target under irradiation
(He/water flows)
• Supply description
• Power
• Compressed air
• Helium cooling
• Water cooling IN and OUT
Shuttle dimensions :
D28x35mm
Alceo Halogen
123/124I target shuttle
(Haynes alloy + Pt)
Hi-tmp melting shuttle
Alceo Metal
89Zr/45Ti target shuttle
(Aluminium + Pt)
Foil shuttle
Alceo Metal
64Cu/68Ga target shuttle
(Aluminium + Pt)
Plating shuttle
• Storage targets
• Sending/receiving the target to/from PTS
• 64Ni plating
• 64Cu Dissolution
• 68Zn plating
• 68Ga Dissolution
• 89Zr Dissolution
• 45Ti Dissolution
PTS
TADDEO-PRF
Dissolutionirradiatedtaregt
• EDS or
• DISSOLUTION UNIT
Labeling
64Cu Production kit 45Ti/89Zr Production kit 68Ga Production kit
Zn powder ZnCl2 solution
• Electroplate
• Clean after plating
• Send
• Irradiate
• Receive
• Ga-Dissolve&Ga-Purify
• Zn recovery
• Clean after purification
• Waste cassette
68Zn
68Ga
68Zn(p,n)68Ga 5mL Gallium Chloride in HCl 1M
 Expectd saturation yield 45mCi/uA
(max current 35uA)
6h
PAPER BURN
PLATING
57,9mg
BEAM
Start Beam 10:00
EOB 10:19
Current 10uA
Irradiation 180min
68Ga Production
Activity
EOB
399mCi
Yield
(EOB)
47,4 mCiuA
PAPER BURN
PLATING
49,1mg
BEAM
Start Beam 10:00
EOB 10:19
Current 10uA
Irradiation 20min
68Ga Production
Activity
EOB
45,31 mCi
10:19 (9/9/16)
Yield
(EOB)
24,5mCiuA
DEGRADER 320um (14,4MeV)
DEGRADER 640um (12,1MeV)
GALLIUM (68Ga) CHLORIDE
SOLUTION FOR RADIOLABELLING
Gamma analysis comparison ALCEO-
GENERATOR production
European Pharmacopoeia
Half life: 62-74min
Test Result
Radionuclidic purity % 67Ga at EOP = 0,019%
pH <2
Fe (ppb) Prod1: 332 Prod2: 1350
Zn (ppb) Prod1: 371 Prod2: 5130
GALLIUM (68Ga) CHLORIDE SOLUTION
FOR RADIOLABELLING
European Pharmacopoeia
Gallium-68: min 99.9 %of the total radioactivity
• pH = max 2.
• Iron = maximum 10µg/GBq.
• Zinc = maximum 10µg/GBq.
13
68Ga-DOTATATE 68Ga-PSMA
Products
SYNTHESIS HPLC
EOS
activity
(MBq)
Synthesis
yield
Decay corrected
yield
Radiochemical
purity
Free 68Ga3+
DOTATATE 888 76,0% 88,6% 91,3% 0,25%
PSMA 570 79,2% 89,6% 99,0%
Not
detected
• Send
• Irradiate
• Receive
• Ti-Dissolve
• Ti-Purify
• Clean after purification
• Waste cassette
45Sc
45Ti
45Sc(p,n)45Ti
Foil D15, 5mm, thickness 0,25mm
 1,2ml Titanium Oxalate in
Oxalic acid 1M
 Expectd saturation yield
9mCi/uA (max current 25uA)
PAPER BURN
10uA 15sec
BEAM
EOB
Current 25uA
Irradiation 2 h
89ZrProduction
Activity 75,7mCi
Measure Time
Yield (EOB) 8,43mCi/uA
45Ti
45Ti
45Ti
45Ti
89Zr
EXPECTED YIELDS
Isotope
Max Current
[µA]
Typical Irradiation
Time [h]
Saturation Yield
[mCi/µA]
Ga-68 30 3 ≥45
Ti-45 25 3 ≥10
GALLIUM (68Ga) CHLORIDE
Saturation Yield [mCi/µAh] ≥45
Irradiation time = 3h
Applied current = 30µA
Expected Activity > 1Ci
68Ga production of 1100 mCi
18
THANK YOU
See you in booth #663

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ALCEO Solid Target Presentation at SNMMI Annual Meeting 2018

  • 3. 64Cu 89Zr 203Pb ALCEO METAL ALCEO HALOGEN 123/124I68Ga 45Ti 44Sc
  • 4. PTS & COOLING SYSTEM EDS 3.0 TADDEO
  • 5. GE PETtrace - Not shielded cyclotron GE PETtrace - Self shielded cyclotron Generic external beam line IBA Cyclone or Kiube cyclotron
  • 6. • Installed outside the bunker • Cools down the target under irradiation (He/water flows) • Supply description • Power • Compressed air • Helium cooling • Water cooling IN and OUT
  • 7. Shuttle dimensions : D28x35mm Alceo Halogen 123/124I target shuttle (Haynes alloy + Pt) Hi-tmp melting shuttle Alceo Metal 89Zr/45Ti target shuttle (Aluminium + Pt) Foil shuttle Alceo Metal 64Cu/68Ga target shuttle (Aluminium + Pt) Plating shuttle
  • 8. • Storage targets • Sending/receiving the target to/from PTS • 64Ni plating • 64Cu Dissolution • 68Zn plating • 68Ga Dissolution • 89Zr Dissolution • 45Ti Dissolution PTS TADDEO-PRF Dissolutionirradiatedtaregt
  • 9. • EDS or • DISSOLUTION UNIT Labeling 64Cu Production kit 45Ti/89Zr Production kit 68Ga Production kit
  • 10. Zn powder ZnCl2 solution • Electroplate • Clean after plating • Send • Irradiate • Receive • Ga-Dissolve&Ga-Purify • Zn recovery • Clean after purification • Waste cassette 68Zn 68Ga 68Zn(p,n)68Ga 5mL Gallium Chloride in HCl 1M  Expectd saturation yield 45mCi/uA (max current 35uA) 6h
  • 11. PAPER BURN PLATING 57,9mg BEAM Start Beam 10:00 EOB 10:19 Current 10uA Irradiation 180min 68Ga Production Activity EOB 399mCi Yield (EOB) 47,4 mCiuA PAPER BURN PLATING 49,1mg BEAM Start Beam 10:00 EOB 10:19 Current 10uA Irradiation 20min 68Ga Production Activity EOB 45,31 mCi 10:19 (9/9/16) Yield (EOB) 24,5mCiuA DEGRADER 320um (14,4MeV) DEGRADER 640um (12,1MeV)
  • 12. GALLIUM (68Ga) CHLORIDE SOLUTION FOR RADIOLABELLING Gamma analysis comparison ALCEO- GENERATOR production European Pharmacopoeia Half life: 62-74min Test Result Radionuclidic purity % 67Ga at EOP = 0,019% pH <2 Fe (ppb) Prod1: 332 Prod2: 1350 Zn (ppb) Prod1: 371 Prod2: 5130 GALLIUM (68Ga) CHLORIDE SOLUTION FOR RADIOLABELLING European Pharmacopoeia Gallium-68: min 99.9 %of the total radioactivity • pH = max 2. • Iron = maximum 10µg/GBq. • Zinc = maximum 10µg/GBq.
  • 13. 13 68Ga-DOTATATE 68Ga-PSMA Products SYNTHESIS HPLC EOS activity (MBq) Synthesis yield Decay corrected yield Radiochemical purity Free 68Ga3+ DOTATATE 888 76,0% 88,6% 91,3% 0,25% PSMA 570 79,2% 89,6% 99,0% Not detected
  • 14. • Send • Irradiate • Receive • Ti-Dissolve • Ti-Purify • Clean after purification • Waste cassette 45Sc 45Ti 45Sc(p,n)45Ti Foil D15, 5mm, thickness 0,25mm  1,2ml Titanium Oxalate in Oxalic acid 1M  Expectd saturation yield 9mCi/uA (max current 25uA)
  • 15. PAPER BURN 10uA 15sec BEAM EOB Current 25uA Irradiation 2 h 89ZrProduction Activity 75,7mCi Measure Time Yield (EOB) 8,43mCi/uA
  • 17. EXPECTED YIELDS Isotope Max Current [µA] Typical Irradiation Time [h] Saturation Yield [mCi/µA] Ga-68 30 3 ≥45 Ti-45 25 3 ≥10 GALLIUM (68Ga) CHLORIDE Saturation Yield [mCi/µAh] ≥45 Irradiation time = 3h Applied current = 30µA Expected Activity > 1Ci 68Ga production of 1100 mCi
  • 18. 18 THANK YOU See you in booth #663