ALCEO Solid Target Presentation at SNMMI Annual Meeting 2018
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Comecer's Solid Target Specialist Mario Maliconico presented this slide deck on June 26th, 2018, during a session titled "Automation for Radionuclide: Production and Synthesis." Updated results based on the ALCEO Solid Target System are presented.
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ALCEO Solid Target Presentation at SNMMI Annual Meeting 2018
- 3. 64Cu 89Zr 203Pb ALCEO METAL ALCEO HALOGEN 123/124I68Ga 45Ti 44Sc
- 4. PTS & COOLING SYSTEM EDS 3.0 TADDEO
- 5. GE PETtrace - Not shielded cyclotron GE PETtrace - Self shielded cyclotron Generic external beam line IBA Cyclone or Kiube cyclotron
- 6. • Installed outside the bunker • Cools down the target under irradiation (He/water flows) • Supply description • Power • Compressed air • Helium cooling • Water cooling IN and OUT
- 7. Shuttle dimensions : D28x35mm Alceo Halogen 123/124I target shuttle (Haynes alloy + Pt) Hi-tmp melting shuttle Alceo Metal 89Zr/45Ti target shuttle (Aluminium + Pt) Foil shuttle Alceo Metal 64Cu/68Ga target shuttle (Aluminium + Pt) Plating shuttle
- 8. • Storage targets • Sending/receiving the target to/from PTS • 64Ni plating • 64Cu Dissolution • 68Zn plating • 68Ga Dissolution • 89Zr Dissolution • 45Ti Dissolution PTS TADDEO-PRF Dissolutionirradiatedtaregt
- 9. • EDS or • DISSOLUTION UNIT Labeling 64Cu Production kit 45Ti/89Zr Production kit 68Ga Production kit
- 10. Zn powder ZnCl2 solution • Electroplate • Clean after plating • Send • Irradiate • Receive • Ga-Dissolve&Ga-Purify • Zn recovery • Clean after purification • Waste cassette 68Zn 68Ga 68Zn(p,n)68Ga 5mL Gallium Chloride in HCl 1M Expectd saturation yield 45mCi/uA (max current 35uA) 6h
- 11. PAPER BURN PLATING 57,9mg BEAM Start Beam 10:00 EOB 10:19 Current 10uA Irradiation 180min 68Ga Production Activity EOB 399mCi Yield (EOB) 47,4 mCiuA PAPER BURN PLATING 49,1mg BEAM Start Beam 10:00 EOB 10:19 Current 10uA Irradiation 20min 68Ga Production Activity EOB 45,31 mCi 10:19 (9/9/16) Yield (EOB) 24,5mCiuA DEGRADER 320um (14,4MeV) DEGRADER 640um (12,1MeV)
- 12. GALLIUM (68Ga) CHLORIDE SOLUTION FOR RADIOLABELLING Gamma analysis comparison ALCEO- GENERATOR production European Pharmacopoeia Half life: 62-74min Test Result Radionuclidic purity % 67Ga at EOP = 0,019% pH <2 Fe (ppb) Prod1: 332 Prod2: 1350 Zn (ppb) Prod1: 371 Prod2: 5130 GALLIUM (68Ga) CHLORIDE SOLUTION FOR RADIOLABELLING European Pharmacopoeia Gallium-68: min 99.9 %of the total radioactivity • pH = max 2. • Iron = maximum 10µg/GBq. • Zinc = maximum 10µg/GBq.
- 13. 13 68Ga-DOTATATE 68Ga-PSMA Products SYNTHESIS HPLC EOS activity (MBq) Synthesis yield Decay corrected yield Radiochemical purity Free 68Ga3+ DOTATATE 888 76,0% 88,6% 91,3% 0,25% PSMA 570 79,2% 89,6% 99,0% Not detected
- 14. • Send • Irradiate • Receive • Ti-Dissolve • Ti-Purify • Clean after purification • Waste cassette 45Sc 45Ti 45Sc(p,n)45Ti Foil D15, 5mm, thickness 0,25mm 1,2ml Titanium Oxalate in Oxalic acid 1M Expectd saturation yield 9mCi/uA (max current 25uA)
- 15. PAPER BURN 10uA 15sec BEAM EOB Current 25uA Irradiation 2 h 89ZrProduction Activity 75,7mCi Measure Time Yield (EOB) 8,43mCi/uA
- 17. EXPECTED YIELDS Isotope Max Current [µA] Typical Irradiation Time [h] Saturation Yield [mCi/µA] Ga-68 30 3 ≥45 Ti-45 25 3 ≥10 GALLIUM (68Ga) CHLORIDE Saturation Yield [mCi/µAh] ≥45 Irradiation time = 3h Applied current = 30µA Expected Activity > 1Ci 68Ga production of 1100 mCi
- 18. 18 THANK YOU See you in booth #663