The document summarizes the AKT/PKB signaling pathway. It discusses that AKT/PKB promotes metabolism, proliferation, and cell survival as an intracellular signal transduction pathway. Key proteins in the pathway are AKT/PKB and PI3K. The pathway regulates processes like protein synthesis, cell survival, cell proliferation, and glucose metabolism. Dysregulation of the pathway through mutations can contribute to cancer due to AKT/PKB's role in regulating critical cellular functions, making it a potential therapeutic target.

1. AKT/PKB SIGNALING PATHWAY
Presented By
P. Veeresh
NIPER A1719PC07
M.S. Dept. of Pharmacology & Toxicology
National Institute of Pharmaceutical Education & research,
Ahmedabad.

2. A brief history of AKT pathway
 Intracellular signal transduction pathway
that promotes
Metabolism
Proliferation
Cell survival
 Key proteins: AKT/PKB & PI3K
 AKT/PKB was discovered as a proto
oncogene in virus termed ATK8, then later
isolated and named AKT
 PIP3k an enzyme had been isolated in
1990 by group of cantley

3. Composition of pathway
RTKs
PI3K
PIP2
PIP3
AKT/PKB

4. pathway
Cell survival Cell proliferation

5. PROTEIN SYNTHESIS
AKT
TSC1 TSC2
mTORC1
PROTEIN SYNTHESIS

6. CELL SURVIVAL
BAD CAS9 IKK YAP Mdm2 CREB
NFkB P73
Bcl2, pro survival genes Bax P53 Bcl2
Bcl xl
AKT
Direct regulation of apoptosis Transcriptional control of apoptosis

7. CELL PROLIFERATION
AKT
CDK,s CYCLIN
Cell cycle
P21
p27
GSK3

8. Glucose metabolism
I
AKT
GS
G G
Glycogen
GLUT
4
GLUT
1

9. CASCADE

10. REGULATION OF AKT/PKB SIGNALING

11. RELATIONSHIP WITH CANCER
 Over activation of pathway
 Mutations:
PI3K
PTEN
AKT/PKB
Due to the critical role of AKT/PKB
in regulating diverse cellular functions it is an
imp therapeutic target for the treatment of
human diseases

12. AKT PATHWAY INHIBOTORS FOR TREATING
CANCER