The document summarizes the AKT/PKB signaling pathway. It discusses that AKT/PKB promotes metabolism, proliferation, and cell survival as an intracellular signal transduction pathway. Key proteins in the pathway are AKT/PKB and PI3K. The pathway regulates processes like protein synthesis, cell survival, cell proliferation, and glucose metabolism. Dysregulation of the pathway through mutations can contribute to cancer due to AKT/PKB's role in regulating critical cellular functions, making it a potential therapeutic target.
Includes notes about Akt/Protein kinase B.Protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration
This file also includes the types, \signalling pathways and inhibitors of protein kinase B.
MAPK Signaling pathway (Mitogen-activated protein kinase), how the pathway helps in regulation of mitosis, It's activation and inactivation inside the cell, roles of MAPK pathway in cancerous cell, different classes of MAP kinase in human
Includes notes about Akt/Protein kinase B.Protein kinase is a kinase enzyme that modifies other proteins by chemically adding phosphate groups to them (phosphorylation).
Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, transcription and cell migration
This file also includes the types, \signalling pathways and inhibitors of protein kinase B.
MAPK Signaling pathway (Mitogen-activated protein kinase), how the pathway helps in regulation of mitosis, It's activation and inactivation inside the cell, roles of MAPK pathway in cancerous cell, different classes of MAP kinase in human
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The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. The pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signalling: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals).[1] Disrupted JAK-STAT signalling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system.
A detailed description of programmed cell death mechanism also called Apoptosis.
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here is some information about autophagy, how it happend, when it happend and it's mechanism.
and some information about it's effect on cancer and some disorders.
PI3K-Akt Pathway is an intracellular signal transduction pathway that promotes metabolism, proliferation, cell survival, growth and angiogenesis in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Key proteins involved are phosphatidylinositol 3-kinase (PI3K) and Akt/Protein Kinase B.
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The JAK-STAT signalling pathway is a chain of interactions between proteins in a cell, and is involved in processes such as immunity, cell division, cell death and tumour formation. The pathway communicates information from chemical signals outside of a cell to the cell nucleus, resulting in the activation of genes through a process called transcription. There are three key parts of JAK-STAT signalling: Janus kinases (JAKs), Signal Transducer and Activator of Transcription proteins (STATs), and receptors (which bind the chemical signals).[1] Disrupted JAK-STAT signalling may lead to a variety of diseases, such as skin conditions, cancers, and disorders affecting the immune system.
A detailed description of programmed cell death mechanism also called Apoptosis.
It explains about the factors, mechanism and pathways involved in the apoptosis.
here is some information about autophagy, how it happend, when it happend and it's mechanism.
and some information about it's effect on cancer and some disorders.
PI3K-Akt Pathway is an intracellular signal transduction pathway that promotes metabolism, proliferation, cell survival, growth and angiogenesis in response to extracellular signals. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Key proteins involved are phosphatidylinositol 3-kinase (PI3K) and Akt/Protein Kinase B.
Chemokines are small proteins, usually ~70–80 amino acid residues, with conserved sequence and structural features and expressed in tissues during normal immune surveillance or in response to injury or infection.
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The Indian economy is classified into different sectors to simplify the analysis and understanding of economic activities. For Class 10, it's essential to grasp the sectors of the Indian economy, understand their characteristics, and recognize their importance. This guide will provide detailed notes on the Sectors of the Indian Economy Class 10, using specific long-tail keywords to enhance comprehension.
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Students, digital devices and success - Andreas Schleicher - 27 May 2024..pptx
AKT/PKB SIGNALING PATHWAY
1. AKT/PKB SIGNALING PATHWAY
Presented By
P. Veeresh
NIPER A1719PC07
M.S. Dept. of Pharmacology & Toxicology
National Institute of Pharmaceutical Education & research,
Ahmedabad.
2. A brief history of AKT pathway
Intracellular signal transduction pathway
that promotes
Metabolism
Proliferation
Cell survival
Key proteins: AKT/PKB & PI3K
AKT/PKB was discovered as a proto
oncogene in virus termed ATK8, then later
isolated and named AKT
PIP3k an enzyme had been isolated in
1990 by group of cantley
6. CELL SURVIVAL
BAD CAS9 IKK YAP Mdm2 CREB
NFkB P73
Bcl2, pro survival genes Bax P53 Bcl2
Bcl xl
AKT
Direct regulation of apoptosis Transcriptional control of apoptosis
11. RELATIONSHIP WITH CANCER
Over activation of pathway
Mutations:
PI3K
PTEN
AKT/PKB
Due to the critical role of AKT/PKB
in regulating diverse cellular functions it is an
imp therapeutic target for the treatment of
human diseases
